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Biology and Biochemistry

D-Index
74
Citations
23719
World Ranking
5511
National Ranking
2620

Overview

Richard T. Premont is affiliated with University Hospitals of Cleveland in the United States and has contributed extensively to the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Their research spans multiple subfields including Molecular Biology, Physiology, Cell Biology, Endocrine and Autonomic Systems, and Cancer Research.

The scientist's work focuses on central topics such as Nitric Oxide and Endothelin Effects, Receptor Mechanisms and Signaling, Hemoglobin structure and function, Neuroscience of respiration and sleep, Neuropeptides and Animal Physiology, Mitochondrial Function and Pathology, and Cancer, Hypoxia, and Metabolism.

Premont's recent scholarly output includes papers published in prominent journals. Selected recent publications are:

  • "An enzyme that selectively S-nitrosylates proteins to regulate insulin signaling," 2023, Cell
  • "The manifold roles of protein S-nitrosylation in the life of insulin," 2021, Nature Reviews Endocrinology
  • "β-Arrestin2 is a critical component of the GPCR-eNOS signalosome," 2020, Proceedings of the National Academy of Sciences
  • "A multienzyme S-nitrosylation cascade regulates cholesterol homeostasis," 2022, Cell Reports
  • "S-nitrosylation is required for β2AR desensitization and experimental asthma," 2022, Molecular Cell

Frequently collaborating with other researchers, Premont has coauthored many papers with Jonathan S. Stamler, Zhaoxia Qian, Zachary W. Grimmett, Rongli Zhang, and Alfred Hausladen.

The scientist has published multiple works in certain venues, including:

  • Proceedings of the National Academy of Sciences (4 publications)
  • UNC Libraries (3 publications)
  • Antioxidants and Redox Signaling (2 publications)
  • STAR Protocols (2 publications)
  • eLife (2 publications)

Best Publications

  • Seven-transmembrane receptors.

    Kristen L. Pierce;Richard T. Premont;Robert J. Lefkowitz

  • DESENSITIZATION OF G PROTEIN–COUPLED RECEPTORS AND NEURONAL FUNCTIONS

    Raul R. Gainetdinov;Richard T. Premont;Laura M. Bohn;Robert J. Lefkowitz

  • β-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the β2 Adrenergic Receptor

    Sudha K. Shenoy;Matthew T. Drake;Christopher D. Nelson;Daniel A. Houtz

  • The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.

    Randy A. Hall;Richard T. Premont;Chung-Wai Chow;Jeremy T. Blitzer

  • Protein kinases that phosphorylate activated G protein-coupled receptors.

    Richard T. Premont;James Inglese;Robert J. Lefkowitz

  • Physiological Roles of G Protein–Coupled Receptor Kinases and Arrestins

    Richard T. Premont;Raul R. Gainetdinov

  • A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.

    Randy A. Hall;Lynda S. Ostedgaard;Richard T. Premont;Jeremy T. Blitzer

  • Heptahelical Receptor Signaling: Beyond the G Protein Paradigm

    Randy A. Hall;Richard T. Premont;Robert J. Lefkowitz

  • Niclosamide: Beyond an antihelminthic drug.

    Wei Chen;Robert A. Mook;Richard T. Premont;Jiangbo Wang

  • beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.

    Richard T. Premont;Audrey Claing;Nicolas Vitale;Jennifer L. R. Freeman

  • Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice

    Alan M. Fong;Richard T. Premont;Ricardo M. Richardson;Yen-Rei A. Yu

  • β-Arrestin-mediated ADP-ribosylation Factor 6 Activation and β2-Adrenergic Receptor Endocytosis

    Audrey Claing;Wei Chen;William E. Miller;Nicolas Vitale

  • A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension.

    Songling Liu;Richard T Premont;Christopher D Kontos;Shoukang Zhu

  • A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins.

    Shubha Bagrodia;Dennis Bailey;Zoe Lenard;Matt Hart

  • Stimulation of specific types of Gs-stimulated adenylyl cyclases by phorbol ester treatment.

    O. Jacobowitz;Jianqiang Chen;R. T. Premont;Ravi Iyengar

  • Identification and Characterization of a Widely Expressed Form of Adenylyl Cyclase

    Richard T. Premont;Isao Matsuoka;Marie-Genevieve Mattei;Yves Pouille

  • Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies.

    JA Pitcher;ZL Fredericks;WC Stone;RT Premont

  • Characterization of the G Protein-coupled Receptor Kinase GRK4 IDENTIFICATION OF FOUR SPLICE VARIANTS

    Richard T. Premont;Alexander D. Macrae;Robert H. Stoffel;Namjin Chung

  • Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells.

    Kuo Du;Jeongeun Hyun;Richard T. Premont;Steve S. Choi

  • Hedgehog controls hepatic stellate cell fate by regulating metabolism.

    Yuping Chen;Steve S. Choi;Steve S. Choi;Gregory A. Michelotti;Isaac S. Chan

Frequent Co-Authors

Robert J. Lefkowitz
Robert J. Lefkowitz Duke University
Anna Mae Diehl
Anna Mae Diehl Duke University
Ravi Iyengar
Ravi Iyengar Icahn School of Medicine at Mount Sinai
Marc G. Caron
Marc G. Caron Duke University
Raul R. Gainetdinov
Raul R. Gainetdinov Saint Petersburg State University
Jonathan S. Stamler
Jonathan S. Stamler Case Western Reserve University
James Inglese
James Inglese National Institutes of Health
Nicolas Vitale
Nicolas Vitale Centre national de la recherche scientifique, CNRS
Paul A. Randazzo
Paul A. Randazzo National Institutes of Health
Tatyana D. Sotnikova
Tatyana D. Sotnikova Italian Institute of Technology

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