D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 90 Citations 29,865 299 World Ranking 7647 National Ranking 4130
Biology and Biochemistry D-index 93 Citations 31,778 295 World Ranking 1363 National Ranking 801

Research.com Recognitions

Awards & Achievements

2018 - Fellow of the Indian National Academy of Engineering (INAE)

2014 - Fellow of the American Association for the Advancement of Science (AAAS)

2013 - Fellow, National Academy of Inventors

Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Internal medicine
  • Genetics

Stephen B. Liggett spends much of his time researching Internal medicine, Endocrinology, Receptor, Heart failure and Agonist. His Internal medicine research includes elements of Denatonium and Valine. His research in Endocrinology intersects with topics in Cardiac function curve and Phospholamban.

Adrenergic receptor is the focus of his Receptor research. His Heart failure research includes themes of Muscle hypertrophy, Heart disease and Beta adrenergic receptor kinase. His studies in Agonist integrate themes in fields like Beta-1 adrenergic receptor, Molecular biology and Methacholine.

His most cited work include:

  • Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. (916 citations)
  • Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. (740 citations)
  • Transgenic Gαq overexpression induces cardiac contractile failure in mice (598 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in Receptor, Internal medicine, Endocrinology, Agonist and Adrenergic receptor. The study incorporates disciplines such as Molecular biology and Signal transduction, Cell biology in addition to Receptor. His Internal medicine study frequently links to other fields, such as Cardiology.

His research integrates issues of Adrenergic and Protein kinase A in his study of Endocrinology. His research in Agonist intersects with topics in Tachyphylaxis and Downregulation and upregulation. His Adrenergic receptor research includes elements of Disease and Pharmacology.

He most often published in these fields:

  • Receptor (47.00%)
  • Internal medicine (47.00%)
  • Endocrinology (41.96%)

What were the highlights of his more recent work (between 2011-2021)?

  • Receptor (47.00%)
  • Cell biology (15.77%)
  • Internal medicine (47.00%)

In recent papers he was focusing on the following fields of study:

Stephen B. Liggett mainly focuses on Receptor, Cell biology, Internal medicine, Endocrinology and Agonist. The study incorporates disciplines such as Tachyphylaxis, Pharmacology, Cell and Downregulation and upregulation in addition to Receptor. His work on G protein, Kinase, Phosphorylation and Myocyte as part of his general Cell biology study is frequently connected to Tauopathy, thereby bridging the divide between different branches of science.

His study in Internal medicine is interdisciplinary in nature, drawing from both Pharmacogenetics and Cardiology. His Endocrinology research is multidisciplinary, incorporating perspectives in Haplotype, Bronchodilator, Function and Adrenergic receptor. His work in Agonist covers topics such as Internalization which are related to areas like TAS2R14, Desensitization, Gene knockdown and CREB.

Between 2011 and 2021, his most popular works were:

  • Extraoral bitter taste receptors as mediators of off-target drug effects (96 citations)
  • TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis. (68 citations)
  • Bitter Taste Receptor Function in Asthmatic and Nonasthmatic Human Airway Smooth Muscle Cells (55 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Internal medicine
  • Genetics

Stephen B. Liggett mainly investigates Internal medicine, Endocrinology, Receptor, Myocyte and Stimulation. His study brings together the fields of Cardiology and Internal medicine. His Endocrinology study combines topics in areas such as Adrenergic receptor, Pharmacogenetics, Intracellular, Bronchodilator and Haplotype.

His Receptor study integrates concerns from other disciplines, such as Tachyphylaxis, Cell, Taste and Cell biology. His Tachyphylaxis research incorporates elements of Agonist and Homologous desensitization. His Myocyte research is multidisciplinary, relying on both Inflammation and Rho-associated protein kinase.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness.

Connie M. Drysdale;Dennis W. McGraw;Catharine B. Stack;J. Claiborne Stephens.
Proceedings of the National Academy of Sciences of the United States of America (2000)

1207 Citations

Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties.

Stuart A. Green;Jamal Turki;Michael Innis;Stephen B. Liggett.
Biochemistry (1994)

1171 Citations

Transgenic Gαq overexpression induces cardiac contractile failure in mice

Drew D. D’Angelo;Yoshihito Sakata;John N. Lorenz;Gregory P. Boivin.
Proceedings of the National Academy of Sciences of the United States of America (1997)

938 Citations

Mutations in the Gene Encoding for the β2-adrenergic Receptor in Normal and Asthmatic Subjects

Ellen Reihsaus;Michael Innis;Neil MacIntyre;Stephen B. Liggett.
American Journal of Respiratory Cell and Molecular Biology (1993)

917 Citations

A Gain-of-function Polymorphism in a G-protein Coupling Domain of the Human β1-Adrenergic Receptor

D A Mason;J D Moore;S A Green;S B Liggett.
Journal of Biological Chemistry (1999)

863 Citations

The Effect of Polymorphisms of the β2-Adrenergic Receptor on the Response to Regular Use of Albuterol in Asthma

Elliot Israel;Jeffrey M. Drazen;Stephen B. Liggett;Homer A. Boushey.
American Journal of Respiratory and Critical Care Medicine (2000)

765 Citations

PKC-alpha regulates cardiac contractility and propensity toward heart failure.

Julian C Braz;Kimberly Gregory;Anand Pathak;Wen Zhao.
Nature Medicine (2004)

703 Citations

Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial

Elliot Israel;Vernon M. Chinchilli;Jean G. Ford;Homer A. Boushey.
The Lancet (2004)

700 Citations

A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor.

S A Green;G Cole;M Jacinto;M Innis.
Journal of Biological Chemistry (1993)

684 Citations

Enhanced Gαq signaling: A common pathway mediates cardiac hypertrophy and apoptotic heart failure

John W. Adams;Yoshihito Sakata;Michael G. Davis;Valerie P. Sah.
Proceedings of the National Academy of Sciences of the United States of America (1998)

676 Citations

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