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D-Index
67
Citations
14534
World Ranking
2906
National Ranking
1347

Overview

Edwin J. Weeber is affiliated with the University of South Florida in the United States. Their research is primarily situated in the fields of Biochemistry, Genetics and Molecular Biology, with additional focus on Neuroscience. Their work spans across various subfields including Genetics, Molecular Biology, Cellular and Molecular Neuroscience, Developmental Neuroscience, and Neurology.

Weeber's research explores topics such as Genetic Syndromes and Imprinting, Epigenetics and DNA Methylation, Genetics and Neurodevelopmental Disorders, Neurogenesis and Neuroplasticity mechanisms, Neuroinflammation and Neurodegeneration Mechanisms, Neuroscience and Neuropharmacology Research, and Phosphodiesterase function and regulation.

The scientist has published numerous papers, with notable recent contributions including:

  • An ASO therapy for Angelman syndrome that targets an evolutionarily conserved region at the start of the UBE3A-AS transcript, 2023, Science Translational Medicine
  • Translational outcomes in a full gene deletion of ubiquitin protein ligase E3A rat model of Angelman syndrome, 2020, Translational Psychiatry
  • Two forms of CX3CL1 display differential activity and rescue cognitive deficits in CX3CL1 knockout mice, 2020, Journal of Neuroinflammation
  • Generation of a Novel Rat Model of Angelman Syndrome with a Complete Ube3a Gene Deletion, 2020, Autism Research
  • Early Developmental EEG and Seizure Phenotypes in a Full Gene Deletion of Ubiquitin Protein Ligase E3A Rat Model of Angelman Syndrome, 2021, eNeuro

Frequent collaborators in their research include:

  • Kevin Nash
  • Anne E. Anderson
  • Scott V. Dindot
  • David J. Segal
  • Jill L. Silverman

Their work often appears in publication venues such as:

  • Autism Research
  • Science Translational Medicine
  • Translational Psychiatry
  • Journal of Neuroinflammation
  • eNeuro

Best Publications

  • Reelin and apoE receptors cooperate to enhance hippocampal synaptic plasticity and learning

    Edwin J. Weeber;Uwe Beffert;Chris Jones;Jill M. Christian

  • CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity.

    Justin T. Rogers;Josh M. Morganti;Adam D. Bachstetter;Charles E. Hudson

  • Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2.

    Uwe Beffert;Edwin J. Weeber;Andre Durudas;Shenfeng Qiu

  • Pet-1 ETS Gene Plays a Critical Role in 5-HT Neuron Development and Is Required for Normal Anxiety-like and Aggressive Behavior

    Timothy J. Hendricks;Dmitry V. Fyodorov;Lauren J. Wegman;Nadia B. Lelutiu

  • A Long CAG Repeat in the Mouse Sca1 Locus Replicates SCA1 Features and Reveals the Impact of Protein Solubility on Selective Neurodegeneration

    Kei Watase;Edwin J. Weeber;Bisong Xu;Barbara Antalffy

  • APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

    Katherine L. Youmans;Leon M. Tai;Evelyn Nwabuisi-Heath;Lisa Jungbauer

  • Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of αCaMKII inhibitory phosphorylation

    Geeske M. Van Woerden;Karen D. Harris;Mohammad Reza Hojjati;Richard M. Gustin

  • Derangements of Hippocampal Calcium/Calmodulin-Dependent Protein Kinase II in a Mouse Model for Angelman Mental Retardation Syndrome

    Edwin J. Weeber;Yong-Hui Jiang;Ype Elgersma;Ype Elgersma;Andrew W. Varga

  • Neuronal LRP1 Knockout in Adult Mice Leads to Impaired Brain Lipid Metabolism and Progressive, Age-Dependent Synapse Loss and Neurodegeneration

    Qiang Liu;Justin Trotter;Juan Zhang;Melinda M. Peters

  • Cognitive disruption and altered hippocampus synaptic function in Reelin haploinsufficient mice

    Shenfeng Qiu;Kimberly M. Korwek;Adeola R. Pratt-Davis;Melinda Peters

  • Integrin Requirement for Hippocampal Synaptic Plasticity and Spatial Memory

    Chi Shing Chan;Edwin J. Weeber;Sindhu Kurup;J. David Sweatt

  • Chemical Manipulation of Hsp70 ATPase Activity Regulates Tau Stability

    Umesh K. Jinwal;Yoshinari Miyata;John Koren;Jeffrey R. Jones

  • Neuronal LRP1 Functionally Associates with Postsynaptic Proteins and Is Required for Normal Motor Function in Mice

    Petra May;Petra May;Astrid Rohlmann;Hans H. Bock;Hans H. Bock;Kai Zurhove;Kai Zurhove

  • Receptor Clustering Is Involved in Reelin Signaling

    Vera Strasser;Daniela Fasching;Christoph Hauser;Harald Mayer

  • ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical Neurons In Vivo

    Sonya B. Dumanis;Joseph A. Tesoriero;Lenard W. Babus;Madeline T. Nguyen

  • SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity.

    Seung Yun Yoo;Mark E. Pennesi;Edwin J. Weeber;Bisong Xu

  • Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus.

    Shenfeng Qiu;Lisa F. Zhao;Kimberly M. Korwek;Edwin J. Weeber

  • Protein Kinase Inhibition by ω-3 Fatty Acids *

    Banafsheh Mirnikjoo;Sarah E. Brown;H. Florence Seung Kim;Lauren B. Marangell

  • Deletion of Apolipoprotein E Receptor-2 in Mice Lowers Brain Selenium and Causes Severe Neurological Dysfunction and Death When a Low-Selenium Diet Is Fed

    Raymond F Burk;Kristina E Hill;Gary E Olson;Edwin J Weeber

  • β1-Integrins Are Required for Hippocampal AMPA Receptor-Dependent Synaptic Transmission, Synaptic Plasticity, and Working Memory

    Chi-Shing Chan;Edwin J. Weeber;Lin Zong;Elaine Fuchs

  • Long-term potentiation and contextual fear conditioning increase neuronal glutamate uptake

    Jonathan Levenson;Edwin Weeber;Joel C. Selcher;Lorna S. Kategaya

Frequent Co-Authors

J. David Sweatt
J. David Sweatt University of Alabama at Birmingham
Anne E. Anderson
Anne E. Anderson Baylor College of Medicine
Eric Klann
Eric Klann New York University
Huda Y. Zoghbi
Huda Y. Zoghbi Baylor College of Medicine
David J. Segal
David J. Segal University of California, Davis
Richard Paylor
Richard Paylor Baylor College of Medicine
Todd E. Golde
Todd E. Golde Emory University
David L. Nelson
David L. Nelson Baylor College of Medicine
Paula C. Bickford
Paula C. Bickford University of South Florida
Peter V. Nguyen
Peter V. Nguyen University of Alberta

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