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Takahisa Kanekiyo

Takahisa Kanekiyo

D-Index & Metrics

Neuroscience

D-Index
60
Citations
15863
World Ranking
3792
National Ranking
1734

Overview

Takahisa Kanekiyo is affiliated with the Mayo Clinic in the United States. Their research primarily focuses on Alzheimer's disease and related neurological conditions, examining molecular mechanisms and pathological processes underlying these disorders.

Their recent scholarly contributions include:

  • APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids, 2020, Nature Communications
  • ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias, 2022, Neuron
  • Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways, 2020, Neuron
  • Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer's disease, 2023, Molecular Neurodegeneration
  • Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function, 2022, Nature Neuroscience

Frequent collaborators in their research include:

  • Guojun Bu
  • Yuka A. Martens
  • Yingxue Ren
  • Chia-Chen Liu
  • Dennis W. Dickson

The venues where Takahisa Kanekiyo has consistently published reflect a focus on neuroscientific and neurodegenerative disease research:

  • Alzheimer s & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuron
  • Molecular Neurodegeneration
  • Science Advances

Their work spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in subfields such as Molecular Biology, Physiology, Neurology, Surgery, and Cellular and Molecular Neuroscience.

Main research topics addressed in their publications consist of:

  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • RNA Interference and Gene Delivery
  • Cholesterol and Lipid Metabolism
  • Mitochondrial Function and Pathology
  • Dementia and Cognitive Impairment Research
  • Epigenetics and DNA Methylation

This broad spectrum of topics encompasses molecular insights into neurodegenerative diseases, exploring genetic risk factors and cellular mechanisms that influence disease progression and cognition. The research integrates molecular biology with clinical neuroscience to elucidate pathways involved in Alzheimer's disease and vascular contributions to cognitive impairment.

Best Publications

  • Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

    Chia Chan Liu;Takahisa Kanekiyo;Huaxi Xu;Guojun Bu

  • ApoE and Aβ in Alzheimer's disease: accidental encounters or partners?

    Takahisa Kanekiyo;Huaxi Xu;Guojun Bu;Guojun Bu

  • Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

    Zhen Zhao;Abhay P Sagare;Qingyi Ma;Matthew R Halliday

  • Blood-Brain Barrier Dysfunction and the Pathogenesis of Alzheimer's Disease.

    Yu Yamazaki;Takahisa Kanekiyo

  • APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

    Jing Zhao;Yuan Fu;Yu Yamazaki;Yingxue Ren

  • APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

    Katherine L. Youmans;Leon M. Tai;Evelyn Nwabuisi-Heath;Lisa Jungbauer

  • Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1

    Takahisa Kanekiyo;John R. Cirrito;Chia Chen Liu;Chia Chen Liu;Mitsuru Shinohara

  • The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer's disease.

    Takahisa Kanekiyo;Guojun Bu

  • Role of LRP1 in the pathogenesis of Alzheimer's disease: evidence from clinical and preclinical studies.

    Mitsuru Shinohara;Masaya Tachibana;Takahisa Kanekiyo;Guojun Bu

  • Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease

    Unknown

  • LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β.

    Takahisa Kanekiyo;Chia Chen Liu;Chia Chen Liu;Mitsuru Shinohara;Jie Li;Jie Li

  • Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition.

    Chia Chen Liu;Jin Hu;Jin Hu;Na Zhao;Jian Wang

  • The role of APOE in cerebrovascular dysfunction

    Leon M. Tai;Riya Thomas;Felecia M. Marottoli;Kevin P. Koster

  • Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown

    Yu Yamazaki;Darren J. Baker;Masaya Tachibana;Chia Chen Liu

  • Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake.

    Takahisa Kanekiyo;Juan Zhang;Qiang Liu;Chia Chen Liu

  • Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer’s Disease

    Chia-Chen Liu;Chia-Chen Liu;Chih-Wei Tsai;Ferenc Deak;Ferenc Deak;Justin Rogers

  • Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways.

    Na Zhao;Yingxue Ren;Yu Yamazaki;Wenhui Qiao

  • APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes.

    Jing Zhao;Mary D. Davis;Yuka A. Martens;Mitsuru Shinohara

  • Prostaglandin D2-Mediated Microglia/Astrocyte Interaction Enhances Astrogliosis and Demyelination in twitcher

    Ikuko Mohri;Masako Taniike;Hidetoshi Taniguchi;Takahisa Kanekiyo

  • Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer's disease.

    Chia Chen Liu;Na Zhao;Yu Yamaguchi;John R. Cirrito

  • Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

    Katherine L. Youmans;Leon M. Tai;Takahisa Kanekiyo;W. Blaine Stine

  • Lipocalin-type prostaglandin D synthase/β-trace is a major amyloid β-chaperone in human cerebrospinal fluid

    Takahisa Kanekiyo;Tadato Ban;Kosuke Aritake;Zhi Li Huang;Zhi Li Huang

Frequent Co-Authors

Huaxi Xu
Huaxi Xu Xiamen University
David M. Holtzman
David M. Holtzman Washington University in St. Louis
Kyeong-Ok Chang
Kyeong-Ok Chang Kansas State University
Zhi-Li Huang
Zhi-Li Huang Fudan University
Julie A. Schneider
Julie A. Schneider Rush University Medical Center

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