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Neuroscience

D-Index
64
Citations
13230
World Ranking
3298
National Ranking
106

Overview

Ype Elgersma is affiliated with Erasmus University Rotterdam in the Netherlands. Their research spans areas primarily within Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broader fields, their work frequently touches on Genetics, Molecular Biology, Neurology, Pediatrics, Perinatology and Child Health, and Epidemiology.

The scientist's research focuses on several main topics, including:

  • Genetic Syndromes and Imprinting
  • Genetics and Neurodevelopmental Disorders
  • Epigenetics and DNA Methylation
  • Prenatal Screening and Diagnostics
  • Neurofibromatosis and Schwannoma Cases
  • Meningioma and schwannoma management
  • Ubiquitin and proteasome pathways

Ype Elgersma has contributed to multiple recent papers, illustrating their active role in cutting-edge genetic and neurodevelopmental research. Among these publications are:

  • "Antisense oligonucleotide treatment rescues UBE3A expression and multiple phenotypes of an Angelman syndrome mouse model" (2021, JCI Insight)
  • "Angelman Syndrome: From Mouse Models to Therapy" (2020, Neuroscience)
  • "TAOK1 is associated with neurodevelopmental disorder and essential for neuronal maturation and cortical development" (2021, Human Mutation)
  • "UBE3A reinstatement as a disease-modifying therapy for Angelman syndrome" (2021, Developmental Medicine & Child Neurology)
  • "Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology" (2021, Cell Reports Medicine)

Collaboration is a notable aspect of Elgersma's research activity. Frequent coauthors include:

  • Geeske M. van Woerden
  • Ben Distel
  • A. Mattijs Punt
  • Ilse Wallaard
  • Edwin Mientjes

The scientist regularly publishes in several academic venues that include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • JCI Insight
  • Molecular Autism
  • Human Molecular Genetics
  • Clinical Neurophysiology

Best Publications

  • Neurofibromin Regulation of ERK Signaling Modulates GABA Release and Learning

    Yijun Cui;Rui M. Costa;Rui M. Costa;Geoffrey G. Murphy;Geoffrey G. Murphy;Ype Elgersma;Ype Elgersma

  • Inhibitory Autophosphorylation of CaMKII Controls PSD Association, Plasticity, and Learning

    Ype Elgersma;Nikolai B Fedorov;Sami Ikonen;Esther S Choi

  • Cerebellar LTD and learning-dependent timing of conditioned eyelid responses.

    S. K. E. Koekkoek;H. C. Hulscher;B. R. Dortland;R. A. Hensbroek

  • Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of αCaMKII inhibitory phosphorylation

    Geeske M. Van Woerden;Karen D. Harris;Mohammad Reza Hojjati;Richard M. Gustin

  • Derangements of Hippocampal Calcium/Calmodulin-Dependent Protein Kinase II in a Mouse Model for Angelman Mental Retardation Syndrome

    Edwin J. Weeber;Yong-Hui Jiang;Ype Elgersma;Ype Elgersma;Andrew W. Varga

  • Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model

    Sara Silva-Santos;Geeske M. van Woerden;Caroline F. Bruinsma;Edwin Mientjes

  • Cognitive deficits in Tsc1+/−mice in the absence of cerebral lesions and seizures

    Susanna M. I. Goorden;Geeske M. van Woerden;Louise van der Weerd;Jeremy Peter Cheadle

  • The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins.

    Y Elgersma;L Kwast;A Klein;T Voorn-Brouwer

  • Purkinje Cell-Specific Knockout of the Protein Phosphatase PP2B Impairs Potentiation and Cerebellar Motor Learning

    M. Schonewille;A. Belmeguenai;A. Belmeguenai;S.K.E. Koekkoek;S.H. Houtman

  • αCaMKII Is Essential for Cerebellar LTD and Motor Learning

    Christian Hansel;Marcel de Jeu;Amor Belmeguenai;Simone Hendrika Houtman

  • Modulation of Presynaptic Plasticity and Learning by the H-ras/Extracellular Signal-Regulated Kinase/Synapsin I Signaling Pathway

    Steven A. Kushner;Ype Elgersma;Ype Elgersma;Geoffrey G. Murphy;Dick Jaarsma

  • Effect of simvastatin on cognitive functioning in children with neurofibromatosis type 1: A randomized controlled trial

    Lianne C. Krab;Arja de Goede-Bolder;Femke K. Aarsen;Saskia M. F. Pluijm

  • Human immunodeficiency virus integrase protein requires a subterminal position of its viral DNA recognition sequence for efficient cleavage.

    C. Vink;D. C. Van Gent;Y. Elgersma;R. H. A. Plasterk

  • Rapid changes in hippocampal CA1 pyramidal cell function via pre- as well as postsynaptic membrane mineralocorticoid receptors.

    J.E. Olijslagers;J.E. Olijslagers;E.R. de Kloet;Y. Elgersma;G.M. van Woerden

  • De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability

    Sébastien Küry;Geeske M van Woerden;Thomas Besnard;Martina Proietti Onori

  • Mouse genetic approaches to investigating calcium/calmodulin-dependent protein kinase II function in plasticity and cognition.

    Ype Elgersma;J. David Sweatt;K. Peter Giese

  • |[beta]|CaMKII controls the direction of plasticity at parallel fiber|[ndash]|Purkinje cell synapses

    Geeske M van Woerden;Freek E Hoebeek;Zhenyu Gao;Raghavendra Y Nagaraja

  • Molecular mechanisms of synaptic plasticity and memory.

    Ype Elgersma;Alcino J Silva

  • Impact of neurofibromatosis type 1 on school performance.

    Lianne C. Krab;Femke K. Aarsen;Arja de Goede-Bolder;Coriene E. Catsman-Berrevoets

  • Simvastatin for cognitive deficits and behavioural problems in patients with neurofibromatosis type 1 (NF1-SIMCODA): a randomised, placebo-controlled trial

    Thijs van der Vaart;Ellen Plasschaert;Ellen Plasschaert;André B Rietman;Marleen Renard

Frequent Co-Authors

Alcino J. Silva
Alcino J. Silva University of California, Los Angeles
Chris I. De Zeeuw
Chris I. De Zeeuw Erasmus University Rotterdam
Dick Jaarsma
Dick Jaarsma Erasmus University Rotterdam
Christian Hansel
Christian Hansel University of Chicago
Rui M. Costa
Rui M. Costa Columbia University
Freek E. Hoebeek
Freek E. Hoebeek Utrecht University
Benjamin D. Philpot
Benjamin D. Philpot University of North Carolina at Chapel Hill
Joke H.M. Tulen
Joke H.M. Tulen Erasmus University Rotterdam
Tjitske Kleefstra
Tjitske Kleefstra Erasmus University Rotterdam
Jan H.J. Hoeijmakers
Jan H.J. Hoeijmakers Erasmus University Rotterdam

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