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Kazuyuki Tobe

Kazuyuki Tobe

D-Index & Metrics

Medicine

D-Index
100
Citations
57762
World Ranking
8119
National Ranking
210

Overview

Kazuyuki Tobe is affiliated with the University of Toyama in Japan and has contributed extensively to research primarily in the fields of Medicine, Biochemistry, Genetics, and Molecular Biology. Their work spans several subfields, including Molecular Biology, Endocrinology, Diabetes and Metabolism, Oncology, Physiology, and Epidemiology.

Their research topics cover a diverse array of subjects, with a focus on diabetes and metabolic studies. Main topics include:

  • Diabetes Treatment and Management
  • Lung Cancer Treatments and Mutations
  • Diet and Metabolism Studies
  • Adipose Tissue and Metabolism
  • Diabetes Management and Research
  • Gut Microbiota and Health
  • Diabetes and Associated Disorders

Tobe's recent publications illustrate a focus on diabetes, metabolism, and associated disorders. Some notable recent papers include:

  • Japanese Clinical Practice Guideline for Diabetes 2019, 2020, published in Diabetology International
  • Japanese Clinical Practice Guideline for Diabetes 2019, 2020, published in Journal of Diabetes Investigation
  • Semaglutide once a week in adults with overweight or obesity, with or without type 2 diabetes in an east Asian population (STEP 6): a randomised, double-blind, double-dummy, placebo-controlled, phase 3a trial, 2022, published in The Lancet Diabetes & Endocrinology
  • Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway, 2020, published in Journal of Cachexia Sarcopenia and Muscle
  • The gut microbiome: a core regulator of metabolism, 2022, published in Journal of Endocrinology

The scientist frequently collaborates with peers in the field, including the following coauthors:

  • Shiho Fujisaka
  • Allah Nawaz
  • Minehiko Inomata
  • Tomonobu Kado
  • Kotaro Tokui

Their scholarly output often appears in several notable publication venues, with multiple articles published in each of the following journals:

  • Diabetes
  • Diabetology International
  • Journal of Diabetes Investigation
  • Case Reports in Rheumatology
  • Scientific Reports

Best Publications

  • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

    T. Yamauchi;J. Kamon;H. Waki;Y. Terauchi

  • Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

    Toshimasa Yamauchi;Junji Kamon;Yusuke Ito;Atsushi Tsuchida

  • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

    Takashi Kadowaki;Toshimasa Yamauchi;Naoto Kubota;Kazuo Hara

  • PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

    Naoto Kubota;Yasuo Terauchi;Hiroshi Miki;Hiroyuki Tamemoto;Hiroyuki Tamemoto

  • Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.

    Toshimasa Yamauchi;Yasunori Nio;Toshiyuki Maki;Masaki Kobayashi

  • Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

    Hiroyuki Tamemoto;Takashi Kadowaki;Kazuyuki Tobe;Takeshi Yagi

  • Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.

    Akira Okuno;Hiroyuki Tamemoto;Kazuyuki Tobe;Kohjiro Ueki

  • Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene

    William S. Chen;Pei Zhang Xu;Kathrin Gottlob;Mei Ling Chen

  • Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance

    Nozomu Kamei;Kazuyuki Tobe;Ryo Suzuki;Mitsuru Ohsugi

  • Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

    Naoto Kubota;Wataru Yano;Tetsuya Kubota;Tetsuya Kubota;Toshimasa Yamauchi

  • Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the japanese population

    Kazuo Hara;Philippe Boutin;Yasumichi Mori;Kazuyuki Tobe

  • Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice

    Shiho Fujisaka;Isao Usui;Agussalim Bukhari;Masashi Ikutani

  • The Mechanisms by Which Both Heterozygous Peroxisome Proliferator-activated Receptor γ (PPARγ) Deficiency and PPARγ Agonist Improve Insulin Resistance

    Toshimasa Yamauchi;Junji Kamon;Hironori Waki;Koji Murakami

  • Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity

    Atsushi Tsuchida;Toshimasa Yamauchi;Yusuke Ito;Yusuke Hada

  • A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA

    T Kadowaki;H Kadowaki;Y Mori;K Tobe

  • Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

    Naoto Kubota;Kazuyuki Tobe;Yasuo Terauchi;Kazuhiro Eto

  • Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation

    Kosei Eguchi;Ichiro Manabe;Yumiko Oishi-Tanaka;Mitsuru Ohsugi

  • Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels.

    Satoshi Nishimura;Ichiro Manabe;Mika Nagasaki;Yumiko Hosoya

  • Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase

    Y. Terauchi;Y. Tsuji;S. Satoh;H. Minoura

  • Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation.

    Yumiko Oishi;Ichiro Manabe;Kazuyuki Tobe;Kensuke Tsushima

Frequent Co-Authors

Takashi Kadowaki
Takashi Kadowaki Toranomon Hospital
Toshimasa Yamauchi
Toshimasa Yamauchi University of Tokyo
Naoto Kubota
Naoto Kubota University of Tokyo
Ryozo Nagai
Ryozo Nagai Jichi Medical University
Yasuo Terauchi
Yasuo Terauchi Yokohama City University
Yasuo Akanuma
Yasuo Akanuma University of Tokyo
Kohjiro Ueki
Kohjiro Ueki National Center For Global Health and Medicine
Yoshio Yazaki
Yoshio Yazaki University of Tokyo
Hirotaka Watada
Hirotaka Watada Juntendo University
Shiro Maeda
Shiro Maeda University of the Ryukyus

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