Yasuo Akanuma

Overview

Best Publications

• Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.

  Akira Okuno;Hiroyuki Tamemoto;Kazuyuki Tobe;Kohjiro Ueki

  1442
  Citations

• Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the japanese population

  Kazuo Hara;Philippe Boutin;Yasumichi Mori;Kazuyuki Tobe

  1013
  Citations

• The Mechanisms by Which Both Heterozygous Peroxisome Proliferator-activated Receptor γ (PPARγ) Deficiency and PPARγ Agonist Improve Insulin Resistance

  Toshimasa Yamauchi;Junji Kamon;Hironori Waki;Koji Murakami

  789
  Citations

• A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA

  T Kadowaki;H Kadowaki;Y Mori;K Tobe

  762
  Citations

• Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

  Naoto Kubota;Kazuyuki Tobe;Yasuo Terauchi;Kazuhiro Eto

  651
  Citations

• Role of NADH Shuttle System in Glucose-Induced Activation of Mitochondrial Metabolism and Insulin Secretion

  Kazuhiro Eto;Yoshiharu Tsubamoto;Yasuo Terauchi;Takuya Sugiyama

  556
  Citations

• Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase

  Y. Terauchi;Y. Tsuji;S. Satoh;H. Minoura

  532
  Citations

• A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats.

  K Murakami;K Tobe;T Ide;T Mochizuki

  516
  Citations

• Potential Role of Protein Kinase B in Insulin-induced Glucose Transport, Glycogen Synthesis, and Protein Synthesis

  Kohjiro Ueki;Ritsuko Yamamoto-Honda;Yasushi Kaburagi;Toshimasa Yamauchi

  461
  Citations

• Long-Term Clinical Effects of Epalrestat, an Aldose Reductase Inhibitor, on Diabetic Peripheral Neuropathy: The 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial

  Nigishi Hotta;Yasuo Akanuma;Ryuzo Kawamori;Kempei Matsuoka

  439
  Citations

• Risk factors for worsening to diabetes in subjects with impaired glucose tolerance

  T. Kadowaki;Y. Miyake;R. Hagura;Y. Akanuma

  435
  Citations

• Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes

  Toshimasa Yamauchi;Hironori Waki;Junji Kamon;Koji Murakami

  399
  Citations

• The Pro12Ala Polymorphism in PPAR γ2 May Confer Resistance to Type 2 Diabetes

  Kazuo Hara;Terumasa Okada;Kazuyuki Tobe;Kazuki Yasuda

  397
  Citations

• Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice.

  T Yamauchi;K Tobe;H Tamemoto;K Ueki

  395
  Citations

• Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

  Toshimasa Yamauchi;Kohjiro Ueki;Kazuyuki Tobe;Hiroyuki Tamemoto

  382
  Citations

• Increase in insulin response after treatment of overt maturity-onset diabetes is independent of the mode of treatment.

  K. Kosaka;T. Kuzuya;Y. Akanuma;R. Hagura

  331
  Citations

• Decreased autophosphorylation of the insulin receptor-kinase in streptozotocin-diabetic rats.

  T Kadowaki;M Kasuga;Y Akanuma;O Ezaki

  323
  Citations

• A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes.

  K. Hara;K. Tobe;T. Okada;H. Kadowaki

  319
  Citations

• A mutation in the beta 3-adrenergic receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects

  Hiroko Kadowaki;kazuki Yasuda;Keishi Iwamoto;Shuichi Otabe

  308
  Citations

• Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation.

  Hiroshi Miki;Toshimasa Yamauchi;Ryo Suzuki;Kajuro Komeda

  278
  Citations