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Naoto Kubota

Naoto Kubota

D-Index & Metrics

Medicine

D-Index
76
Citations
32008
World Ranking
18631
National Ranking
597

Overview

Naoto Kubota is affiliated with the University of Tokyo in Japan and primarily conducts research in the field of Biochemistry, Genetics and Molecular Biology. Their work focuses extensively on Molecular Biology, with further contributions to Cancer Research, Physiology, Epidemiology, and Immunology.

The topics explored in Kubota's research include:

  • RNA modifications and cancer
  • RNA Research and Splicing
  • Single-cell and spatial transcriptomics
  • Genomics and Chromatin Dynamics
  • Cancer-related molecular mechanisms research
  • Adipose Tissue and Metabolism
  • Mitochondrial Function and Pathology

Kubota has authored and co-authored several research papers appearing in recognized scientific journals. Notable recent publications include:

  • An integrated analysis of public genomic data unveils a possible functional mechanism of psoriasis risk via a long-range ERRFI1 enhancer, 2020, BMC Medical Genomics
  • Hepatic SerpinA1 improves energy and glucose metabolism through regulation of preadipocyte proliferation and UCP1 expression, 2024, Nature Communications
  • Epistatic interactions between NMD and TRP53 control progenitor cell maintenance and brain size, 2024, Neuron
  • Shiba: a versatile computational method for systematic identification of differential RNA splicing across platforms, 2025, Nucleic Acids Research

Kubota has collaborated frequently with several co-authors, including:

  • Sika Zheng
  • Mikita Suyama
  • Eiichi Araki
  • Liang Chen
  • David Nikom

Their research findings have been published in various venues, with multiple contributions to bioRxiv (Cold Spring Harbor Laboratory), Zenodo (CERN European Organization for Nuclear Research), and eLife, alongside publications in Nature Communications and Neuron.

Best Publications

  • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

    T. Yamauchi;J. Kamon;H. Waki;Y. Terauchi

  • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome

    Takashi Kadowaki;Toshimasa Yamauchi;Naoto Kubota;Kazuo Hara

  • Disruption of adiponectin causes insulin resistance and neointimal formation.

    Naoto Kubota;Yasuo Terauchi;Toshimasa Yamauchi;Tetsuya Kubota

  • PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance

    Naoto Kubota;Yasuo Terauchi;Hiroshi Miki;Hiroyuki Tamemoto;Hiroyuki Tamemoto

  • Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.

    Toshimasa Yamauchi;Yasunori Nio;Toshiyuki Maki;Masaki Kobayashi

  • Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance

    Nozomu Kamei;Kazuyuki Tobe;Ryo Suzuki;Mitsuru Ohsugi

  • Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1.

    Masato Iwabu;Toshimasa Yamauchi;Miki Okada-Iwabu;Koji Sato

  • Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake

    Naoto Kubota;Wataru Yano;Tetsuya Kubota;Tetsuya Kubota;Toshimasa Yamauchi

  • PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors

    Toru Akune;Shinsuke Ohba;Satoru Kamekura;Masayuki Yamaguchi

  • The Mechanisms by Which Both Heterozygous Peroxisome Proliferator-activated Receptor γ (PPARγ) Deficiency and PPARγ Agonist Improve Insulin Resistance

    Toshimasa Yamauchi;Junji Kamon;Hironori Waki;Koji Murakami

  • Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity

    Atsushi Tsuchida;Toshimasa Yamauchi;Yusuke Ito;Yusuke Hada

  • Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

    Naoto Kubota;Kazuyuki Tobe;Yasuo Terauchi;Kazuhiro Eto

  • A Liver-Derived Secretory Protein, Selenoprotein P, Causes Insulin Resistance

    Hirofumi Misu;Toshinari Takamura;Hiroaki Takayama;Hiroto Hayashi

  • Role of NADH Shuttle System in Glucose-Induced Activation of Mitochondrial Metabolism and Insulin Secretion

    Kazuhiro Eto;Yoshiharu Tsubamoto;Yasuo Terauchi;Takuya Sugiyama

  • Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle

    Tetsuya Kubota;Naoto Kubota;Hiroki Kumagai;Shinichi Yamaguchi

  • Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation.

    Yumiko Oishi;Ichiro Manabe;Kazuyuki Tobe;Kensuke Tsushima

  • Glucokinase and IRS-2 are required for compensatory β cell hyperplasia in response to high-fat diet–induced insulin resistance

    Yasuo Terauchi;Iseki Takamoto;Naoto Kubota;Junji Matsui

  • Role of Krüppel-like Factor 15 (KLF15) in Transcriptional Regulation of Adipogenesis

    Toshiyuki Mori;Hiroshi Sakaue;Haruhisa Iguchi;Hideyuki Gomi

  • Pioglitazone Ameliorates Insulin Resistance and Diabetes by Both Adiponectin-dependent and -independent Pathways

    Naoto Kubota;Yasuo Terauchi;Tetsuya Kubota;Hiroki Kumagai

  • The chromosomal gene structure and two mRNAs for human granulocyte colony-stimulating factor.

    S Nagata;M Tsuchiya;S Asano;O Yamamoto

Frequent Co-Authors

Takashi Kadowaki
Takashi Kadowaki Toranomon Hospital
Yasuo Terauchi
Yasuo Terauchi Yokohama City University
Toshimasa Yamauchi
Toshimasa Yamauchi University of Tokyo
Kazuyuki Tobe
Kazuyuki Tobe University of Toyama
Kohjiro Ueki
Kohjiro Ueki National Center For Global Health and Medicine
Ryozo Nagai
Ryozo Nagai Jichi Medical University
Tetsuo Noda
Tetsuo Noda Japanese Foundation For Cancer Research
Mineo Kurokawa
Mineo Kurokawa University of Tokyo
Satoshi Kimura
Satoshi Kimura University of Tokyo
Yasuo Akanuma
Yasuo Akanuma University of Tokyo

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