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Neuroscience

D-Index
43
Citations
7767
World Ranking
7376
National Ranking
203

Overview

Dick Jaarsma is affiliated with Erasmus University Rotterdam in the Netherlands. Their research spans multiple intersecting fields, primarily within biochemistry, genetics, molecular biology, medicine, and neuroscience. The scientist's work features a strong emphasis on molecular biology, physiology, and cellular and molecular neuroscience, with particular attention to aging and cell biology.

The main topics addressed in their research include mitochondrial function and pathology, genetics, aging and longevity in model organisms, DNA repair mechanisms, genetic neurodegenerative diseases, diet and metabolism studies, circadian rhythm and melatonin, and amyotrophic lateral sclerosis research.

Among their recent published papers are:

  • Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice (2021, Aging Cell)
  • Pathomechanisms of ALS8: altered autophagy and defective RNA binding protein (RBP) homeostasis due to the VAPB P56S mutation (2021, Cell Death and Disease)
  • Region-specific preservation of Purkinje cell morphology and motor behavior in the ATXN1[82Q] mouse model of spinocerebellar ataxia 1 (2021, Brain Pathology)
  • In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration (2021, Acta Neuropathologica Communications)
  • The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside (2022, Frontiers in Aging)

Jaarsma frequently publishes in venues such as Frontiers in Aging, Journal of Cachexia Sarcopenia and Muscle, bioRxiv (Cold Spring Harbor Laboratory), Aging Cell, and Cell Death and Disease.

Collaborations have involved several coauthors, including Wilbert P. Vermeij, María B. Birkisdóttir, Jan H.J. Hoeijmakers, Renata M. C. Brandt, and Sander Barnhoorn. These collaborations highlight an active engagement with research teams focused on molecular and cellular mechanisms related to aging and neurodegeneration.

Best Publications

  • TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites.

    Myrrhe van Spronsen;Myrrhe van Spronsen;Marina Mikhaylova;Marina Mikhaylova;Joanna Lipka;Joanna Lipka;Max A. Schlager

  • Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1.

    Dick Jaarsma;Elize D. Haasdijk;J.A.C. Grashorn;Richard Hawkins

  • Paraneoplastic Cerebellar Ataxia Due to Autoantibodies against a Glutamate Receptor

    Sillevis Smitt P;Kinoshita A;De Leeuw B;Moll W

  • Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

    W. P. Vermeij;M. E T Dollé;E. Reiling;D. Jaarsma

  • CuZn superoxide dismutase (SOD1) accumulates in vacuolated mitochondria in transgenic mice expressing amyotrophic lateral sclerosis-linked SOD1 mutations.

    Dick Jaarsma;Francesca Rognoni;Wim van Duijn;Hein W. Verspaget

  • Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice.

    Dick Jaarsma;Eva Teuling;Elize D Haasdijk;Chris I De Zeeuw

  • Motor Neuron Disease-Associated Mutant Vesicle-Associated Membrane Protein-Associated Protein (VAP) B Recruits Wild-Type VAPs into Endoplasmic Reticulum-Derived Tubular Aggregates

    Eva Teuling;Suaad Ahmed;Elize Haasdijk;Jeroen Demmers

  • Modulation of Presynaptic Plasticity and Learning by the H-ras/Extracellular Signal-Regulated Kinase/Synapsin I Signaling Pathway

    Steven A. Kushner;Ype Elgersma;Ype Elgersma;Geoffrey G. Murphy;Dick Jaarsma

  • MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus KIF5-Dependent Cargo Transport in Sensory Neurons

    Laura F. Gumy;Eugene A. Katrukha;Ilya Grigoriev;Dick Jaarsma

  • Cholinergic innervation and receptors in the cerebellum.

    Dick Jaarsma;Tom J.H. Ruigrok;Romeo Caffé;Constantino Cozzari

  • Deformation of Network Connectivity in the Inferior Olive of Connexin 36-Deficient Mice Is Compensated by Morphological and Electrophysiological Changes at the Single Neuron Level

    Chris I. De Zeeuw;Edilzh Chorev;Anna Devor;Yait Manor

  • ATF3 expression precedes death of spinal motoneurons in amyotrophic lateral sclerosis-SOD1 transgenic mice and correlates with c-Jun phosphorylation, CHOP expression, somato-dendritic ubiquitination and Golgi fragmentation

    Angela S Vlug;Eva Teuling;Elize D Haasdijk;Pim French

  • Dynein Regulator NDEL1 Controls Polarized Cargo Transport at the Axon Initial Segment

    Marijn Kuijpers;Dieudonnée van de Willige;Amélie Freal;Anaël Chazeau

  • Priming of microglia in a DNA-repair deficient model of accelerated aging

    Divya D. A. Raj;Dick Jaarsma;Inge R. Holtman;Marta Olah

  • Accelerated Age-Related Cognitive Decline and Neurodegeneration, Caused by Deficient DNA Repair

    Nils Z Borgesius;Monique C de Waard;Ingrid van der Pluijm;Azar Omrani

  • The unipolar brush cells of the mammalian cerebellum and cochlear nucleus: cytology and microcircuitry.

    Mugnaini E;Diño Mr;Jaarsma D

  • Arc expression identifies the lateral amygdala fear memory trace.

    L.A. Gouty-Colomer;B. Hosseini;I.M. Marcelo;Jadwiga Schreiber

  • βCaMKII Plays a Nonenzymatic Role in Hippocampal Synaptic Plasticity and Learning by Targeting αCaMKII to Synapses

    Nils Z Borgesius;Geeske M van Woerden;Gabrielle H S Buitendijk;Nanda Keijzer

  • Neuron Specific Rab4 Effector GRASP-1 Coordinates Membrane Specialization and Maturation of Recycling Endosomes

    Casper C. Hoogenraad;Ioana Popa;Kensuke Futai;Emma Sanchez-Martinez

  • Time course and distribution of neuronal degeneration in the dentate gyrus of rat after adrenalectomy: a silver impregnation study.

    Dick Jaarsma;Folkert Postema;Jakob Korf

Frequent Co-Authors

Chris I. De Zeeuw
Chris I. De Zeeuw Erasmus University Rotterdam
Jan H.J. Hoeijmakers
Jan H.J. Hoeijmakers Erasmus University Rotterdam
Ype Elgersma
Ype Elgersma Erasmus University Rotterdam
Jan Voogd
Jan Voogd Erasmus University Rotterdam
Tom J. H. Ruigrok
Tom J. H. Ruigrok Erasmus University Rotterdam
Freek E. Hoebeek
Freek E. Hoebeek Utrecht University
Morgan Sheng
Morgan Sheng Broad Institute
Allan I. Levey
Allan I. Levey Emory University
Bart J. L. Eggen
Bart J. L. Eggen University Medical Center Groningen
Jan Vijg
Jan Vijg Albert Einstein College of Medicine

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