World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
14865
World Ranking
7132
National Ranking
3273

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Cancer

Sanjay Awasthi mostly deals with Biochemistry, Glutathione, Oxidative stress, Lipid peroxidation and 4-Hydroxynonenal. His study in Glutathione S-transferase, Antioxidant, Curcumin, Enzyme and Affinity chromatography are all subfields of Biochemistry. Sanjay Awasthi combines subjects such as Molecular biology, ATPase, Isozyme and Transfection with his study of Glutathione.

As a part of the same scientific family, Sanjay Awasthi mostly works in the field of Oxidative stress, focusing on GPX1 and, on occasion, Peroxidase and GPX3. His research in Lipid peroxidation focuses on subjects like GPX4, which are connected to Regulation of gene expression, Oxidative phosphorylation and Caspase. His studies examine the connections between 4-Hydroxynonenal and genetics, as well as such issues in Cell biology, with regards to Caspase 3 and Apoptosis.

His most cited work include:

  • Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties. (421 citations)
  • Role of glutathione S-transferases in protection against lipid peroxidation. Overexpression of hGSTA2-2 in K562 cells protects against hydrogen peroxide-induced apoptosis and inhibits JNK and caspase 3 activation. (279 citations)
  • Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases. (244 citations)

What are the main themes of his work throughout his whole career to date?

Biochemistry, Glutathione, Cancer research, Molecular biology and Apoptosis are his primary areas of study. His Biochemistry study focuses mostly on Lipid peroxidation, Enzyme, Oxidative stress, ATPase and Antioxidant. His Glutathione research incorporates elements of Isozyme and 4-Hydroxynonenal.

As a member of one scientific family, Sanjay Awasthi mostly works in the field of 4-Hydroxynonenal, focusing on Cell biology and, on occasion, Caspase 3. His research on Molecular biology also deals with topics like

  • Transfection which intersects with area such as Cytotoxic T cell,
  • Cell culture which connect with Cancer cell. His work focuses on many connections between Apoptosis and other disciplines, such as Doxorubicin, that overlap with his field of interest in Lung cancer and Cytotoxicity.

He most often published in these fields:

  • Biochemistry (46.82%)
  • Glutathione (42.77%)
  • Cancer research (23.70%)

What were the highlights of his more recent work (between 2017-2021)?

  • Cancer research (23.70%)
  • Cancer (10.98%)
  • Internal medicine (14.45%)

In recent papers he was focusing on the following fields of study:

Sanjay Awasthi mainly investigates Cancer research, Cancer, Internal medicine, Oncology and Apoptosis. His research in Cancer research intersects with topics in Cell culture, Carcinogenesis, Suppressor, Metastasis and Breast cancer. His work deals with themes such as Doxorubicin transport, In vitro, microRNA and In vivo, which intersect with Cancer.

The Oncology study combines topics in areas such as Meta-analysis, Randomized controlled trial and Molecular medicine. His Apoptosis research includes elements of Cell, Signal transduction and Angiogenesis. His study of Sulforaphane is a part of Biochemistry.

Between 2017 and 2021, his most popular works were:

  • Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment (172 citations)
  • Phase IIIb safety results from an expanded-access protocol of talimogene laherparepvec for patients with unresected, stage IIIB-IVM1c melanoma. (17 citations)
  • Prexasertib treatment induces homologous recombination deficiency and synergizes with olaparib in triple-negative breast cancer cells (16 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Cancer

Sanjay Awasthi focuses on Cancer research, Breast cancer, Cell, Apoptosis and Cancer. His Cancer research study also includes fields such as

  • Mechanism of action, Doxorubicin, Nude mouse, Lung cancer and In vitro most often made with reference to Vimentin,
  • Protein kinase B together with Survivin, Viability assay and In vivo. In his study, Hormone, Growth factor, Estrogen receptor, Phosphorylation and Proteomic Profile is inextricably linked to Wnt signaling pathway, which falls within the broad field of Breast cancer.

His study in Cell is interdisciplinary in nature, drawing from both Cell culture, Cytokine, Carcinogenesis, Suppressor and Inflammation. Apoptosis and Malignant transformation are commonly linked in his work. In the field of Cancer, his study on Triple-negative breast cancer overlaps with subjects such as SKBR3.

Best Publications

  • Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties

    Piotr Zimniak;Bindu Nanduri;Sławomir Pikuła;Joanna Bandorowicz-Pikuła

  • Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment

    Shireen Chikara;Lokesh Dalasanur Nagaprashantha;Jyotsana Singhal;David Horne

  • Role of glutathione S-transferases in protection against lipid peroxidation. Overexpression of hGSTA2-2 in K562 cells protects against hydrogen peroxide-induced apoptosis and inhibits JNK and caspase 3 activation.

    Yusong Yang;Ji-Zhong Cheng;Sharad S. Singhal;Manjit Saini

  • Antioxidant Role of Glutathione S-Transferases: Protection Against Oxidant Toxicity and Regulation of Stress-Mediated Apoptosis

    Rajendra Sharma;Yusong Yang;Abha Sharma;Sanjay Awasthi

  • Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver

    John T Piper;Sharad S Singhal;Mohammad S Salameh;Robert T Torman

  • Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling.

    Yusong Yang;Rajendra Sharma;Abha Sharma;Sanjay Awasthi

  • Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases.

    Yogesh C Awasthi;Yusong Yang;Narendra K Tiwari;Brad Patrick

  • Role of 4-hydroxynonenal in stress-mediated apoptosis signaling

    Yogesh C. Awasthi;Rajendra Sharma;J.Z. Cheng;Yusong Yang

  • Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling.

    Sharad S. Singhal;Sharda P. Singh;Preeti Singhal;David Horne

  • Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress.

    Ji-Zhong Cheng;Rajendra Sharma;Yusong Yang;Sharad S. Singhal

  • Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin.

    Sanjay Awasthi;Jizhong Cheng;Sharad S. Singhal;Manjit K. Saini

  • Curcumin protects against 4-hydroxy-2-trans-nonenal-induced cataract formation in rat lenses.

    S Awasthi;S K Srivatava;J T Piper;S S Singhal

  • Mitogenic Responses of Vascular Smooth Muscle Cells to Lipid Peroxidation-derived Aldehyde 4-Hydroxy-trans-2-nonenal (HNE) ROLE OF ALDOSE REDUCTASE-CATALYZED REDUCTION OF THE HNE-GLUTATHIONE CONJUGATES IN REGULATING CELL GROWTH

    Kota V. Ramana;Aruni Bhatnagar;Sanjay Srivastava;Umesh C. S. Yadav

  • Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse.

    Mark R Engle;Sharda P Singh;Piotr J Czernik;Dana Gaddy

  • Interactions of glutathione S-transferase-π with ethacrynic acid and its glutathione conjugate

    Sanjay Awasthi;Sanjay K. Srivastava;Faiyaz Ahmad;Hassan Ahmad

  • Transfection of mGSTA4 in HL-60 cells protects against 4-hydroxynonenal-induced apoptosis by inhibiting JNK-mediated signaling.

    Ji-Zhong Cheng;Sharad S. Singhal;Abha Sharma;Manjit Saini

  • Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): a novel link between G-protein and tyrosine kinase signaling and drug resistance.

    Sanjay Awasthi;Sharad S. Singhal;Rajendra Sharma;Piotr Zimniak

  • Curcumin–glutathione interactions and the role of human glutathione S-transferase P1-1

    Sanjay Awasthi;Utpal Pandya;Sharad S. Singhal;James T. Lin

  • Adenosine triphosphate-dependent transport of doxorubicin, daunomycin, and vinblastine in human tissues by a mechanism distinct from the P-glycoprotein.

    S Awasthi;S S Singhal;S K Srivastava;P Zimniak

  • Regulation of 4-hydroxynonenal mediated signaling by glutathione S-transferases.

    Yogesh C. Awasthi;Ghulam Ansari;Sanjay Awasthi

Frequent Co-Authors

Yogesh C. Awasthi
Yogesh C. Awasthi University of North Texas Health Science Center
Sharad S. Singhal
Sharad S. Singhal The University of Texas at Arlington
Piotr Zimniak
Piotr Zimniak University of Arkansas for Medical Sciences
Sanjay K. Srivastava
Sanjay K. Srivastava Texas Tech University Health Sciences Center
Shivendra V. Singh
Shivendra V. Singh University of Pittsburgh
Ravi Salgia
Ravi Salgia City Of Hope National Medical Center
Satish K. Srivastava
Satish K. Srivastava The University of Texas Medical Branch at Galveston
Arthur D. Riggs
Arthur D. Riggs City Of Hope National Medical Center
Xinhua Ji
Xinhua Ji National Institutes of Health
Damir Janigro
Damir Janigro Case Western Reserve University

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