World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
47
Citations
9898
World Ranking
18634
National Ranking
7622

Overview

Karen A. Hasty is affiliated with the University of Tennessee Health Science Center in the United States. Their research primarily focuses on medicine and biochemistry, genetics, and molecular biology, contributing substantially within these fields.

The scientist's work spans several subfields, including rheumatology, surgery, molecular biology, immunology and allergy, and cancer research. Their research topics cover a range of medical issues with a notable emphasis on osteoarthritis treatment and mechanisms, knee injuries and reconstruction techniques, cell adhesion molecules research, total knee arthroplasty outcomes, rheumatoid arthritis research and therapies, systemic sclerosis and related diseases, and dermatological and skeletal disorders.

Recent papers authored or co-authored by the scientist include:

  • "Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage," 2021, Nature Biomedical Engineering
  • "Top-Down Fabricated microPlates for Prolonged, Intra-articular Matrix Metalloproteinase 13 siRNA Nanocarrier Delivery to Reduce Post-traumatic Osteoarthritis," 2021, ACS Nano
  • "Recent Advances in Clinical Translation of Intra-Articular Osteoarthritis Drug Delivery Systems," 2020, Advanced Therapeutics
  • "17,20S(OH)2pD Can Prevent the Development of Skin Fibrosis in the Bleomycin-Induced Scleroderma Mouse Model," 2021, International Journal of Molecular Sciences
  • "Matrix-targeted Nanoparticles for MMP13 RNA Interference Blocks Post-Traumatic Osteoarthritis," 2020, bioRxiv (Cold Spring Harbor Laboratory)

The scientist frequently publishes in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Biomedical Engineering
  • International Journal of Molecular Sciences
  • ACS Nano
  • Advanced Therapeutics

Collaboration is a significant aspect of their work with several frequent co-authors, including Craig L. Duvall, Hongsik Cho, Juan M. Colazo, David Brand, and Fang Yu.

Best Publications

  • Biochemical and immunological characterization of the secreted forms of human neutrophil gelatinase.

    M S Hibbs;K A Hasty;J M Seyer;A H Kang

  • Glycosylated Hemoglobins and Long-Term Blood Glucose Control in Diabetes Mellitus

    K H Gabbay;K Hasty;J L Breslow;R C Ellison

  • Induction of arthritis with monoclonal antibodies to collagen.

    K Terato;K A Hasty;R A Reife;M A Cremer

  • Human neutrophil collagenase : a distinct gene product with homology to other matrix metalloproteinases

    K. A. Hasty;T. F. Pourmotabbed;Gregory Goldberg;J. P. Thompson

  • Osteoarthritic lesions: involvement of three different collagenases.

    Boris V. Shlopov;Wen-Rong Lie;Carlo L. Mainardi;Ada A. Cole

  • Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vitro.

    William J. Lamoreaux;Malinda E.C. Fitzgerald;Malinda E.C. Fitzgerald;Anton Reiner;Karen A. Hasty

  • The collagen substrate specificity of human neutrophil collagenase

    K A Hasty;J J Jeffrey;M S Hibbs;H G Welgus

  • Autoimmunity due to molecular mimicry as a cause of neurological disease

    Michael C. Levin;Michael C. Levin;Sang Min Lee;Franck Kalume;Yvette Morcos

  • The role of stromelysin in the cartilage destruction that accompanies inflammatory arthritis.

    Karen A. Hasty;Robert A. Reife;Andrew H. Kang;John M. Stuart

  • Chondrocyte Matrix Metalloproteinase-8 HUMAN ARTICULAR CHONDROCYTES EXPRESS NEUTROPHIL COLLAGENASE

    Ada A. Cole;Susan Chubinskaya;Barbara Schumacher;Klaus Huch

  • Specificity of inhibition of matrix metalloproteinase activity by doxycycline: relationship to structure of the enzyme.

    Gerald N. Smith;Elizabeth A. Mickler;Karen A. Hasty;Kenneth D. Brandt

  • Secreted forms of human neutrophil collagenase.

    K A Hasty;M S Hibbs;A H Kang;C L Mainardi

  • Chondrocyte matrix metalloproteinase-8 : up-regulation of neutrophil collagenase by interleukin-1 beta in human cartilage from knee and ankle joints

    S Chubinskaya;K Huch;K Mikecz;G Cs-Szabo

  • Collagen-induced arthritis in mice. Localization of an arthritogenic determinant to a fragment of the type II collagen molecule.

    Kuniaki Terato;Karen A. Hasty;Michael A. Cremer;John M. Stuart

  • Structure-function relationship of human neutrophil collagenase: identification of regions responsible for substrate specificity and general proteinase activity.

    Tomohiko Hirose;Christy Patterson;Tayebeh Pourmotabbed;Carlo L. Mainardi

  • Autocrine regulation of collagenase 3 (matrix metalloproteinase 13) during osteoarthritis.

    Boris V. Shlopov;Marina L. Gumanovskaya;Karen A. Hasty;Karen A. Hasty

  • Differential patterns of response to doxycycline and transforming growth factor β1 in the down-regulation of collagenases in osteoarthritic and normal human chondrocytes

    Boris V. Shlopov;Gerald N. Smith;Ada A. Cole;Karen A. Hasty

  • Proteolytic inactivation of alpha 1-proteinase inhibitor and alpha 1-antichymotrypsin by oxidatively activated human neutrophil metalloproteinases.

    P E Desrochers;K Mookhtiar;H E Van Wart;K A Hasty

  • Proteolysis involving matrix metalloproteinase 13 (collagenase-3) is required for chondrocyte differentiation that is associated with matrix mineralization.

    C. William Wu;C. William Wu;Elena V. Tchetina;Fackson Mwale;Karen Hasty

  • Purification of a type V collagen degrading metalloproteinase from rabbit alveolar macrophages.

    Carlo L. Mainardi;Margaret S. Hibbs;Karen A. Hasty;Jerome M. Seyer

Frequent Co-Authors

John M. Stuart
John M. Stuart University of Tennessee Health Science Center
Arnold E. Postlethwaite
Arnold E. Postlethwaite University of Tennessee Health Science Center
Andrew H. Kang
Andrew H. Kang University of Tennessee Health Science Center
David D. Brand
David D. Brand University of Tennessee Health Science Center
Kenneth D. Brandt
Kenneth D. Brandt University of Kansas
Byoung-Hyun Min
Byoung-Hyun Min Ajou University
Jerome M. Seyer
Jerome M. Seyer University of Tennessee Health Science Center
Leslie J. Crofford
Leslie J. Crofford Vanderbilt University Medical Center
Andrzej Slominski
Andrzej Slominski University of Alabama at Birmingham
Dong Keun Han
Dong Keun Han Korea Institute of Science and Technology

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