World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
12522
World Ranking
9334
National Ranking
4120

Overview

Sharad S. Singhal is affiliated with The University of Texas at Arlington in the United States. Their research is primarily situated within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. They have contributed extensively to specialized subfields including Molecular Biology, Oncology, Cancer Research, Immunology, and Radiology, Nuclear Medicine and Imaging.

The scientist's work covers a range of topics, with notable focus areas that include Cancer Immunotherapy and Biomarkers, CAR-T cell therapy research, Amino Acid Enzymes and Metabolism, Immunotherapy and Immune Responses, Cancer-related Molecular Pathways, PI3K/AKT/mTOR signaling in cancer, and Lung Cancer Research Studies.

Singhal has published extensively, with recurring publications in several key journals. Frequent publication venues include Cancer Research, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Cancers, Journal of Clinical Medicine, and Biochemical Pharmacology.

Notable recent papers authored or co-authored by Sharad S. Singhal include the following:

  • Emerging Therapeutic Strategies to Overcome Drug Resistance in Cancer Cells, 2024, Cancers
  • SOX9: The master regulator of cell fate in breast cancer, 2020, Biochemical Pharmacology
  • Chemokines and NSCLC: Emerging role in prognosis, heterogeneity, and therapeutics, 2022, Seminars in Cancer Biology
  • Next-Generation Immunotherapy: Advancing Clinical Applications in Cancer Treatment, 2024, Journal of Clinical Medicine
  • Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer, 2023, Science Advances

Frequent collaborators in their research include:

  • Ravi Salgia
  • David Horne
  • Sanjay Awasthi
  • Prakash Kulkarni
  • Atish Mohanty

Best Publications

  • Naturally occurring human glutathione S-transferase GSTP1-1 isoforms with isoleucine and valine in position 104 differ in enzymic properties

    Piotr Zimniak;Bindu Nanduri;Sławomir Pikuła;Joanna Bandorowicz-Pikuła

  • Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment

    Shireen Chikara;Lokesh Dalasanur Nagaprashantha;Jyotsana Singhal;David Horne

  • Role of glutathione S-transferases in protection against lipid peroxidation. Overexpression of hGSTA2-2 in K562 cells protects against hydrogen peroxide-induced apoptosis and inhibits JNK and caspase 3 activation.

    Yusong Yang;Ji-Zhong Cheng;Sharad S. Singhal;Manjit Saini

  • Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver

    John T Piper;Sharad S Singhal;Mohammad S Salameh;Robert T Torman

  • Human glutathione S-transferases

    Yogesh C. Awasthi;Rashmi Sharma;Sharad S. Singhal

  • Role of 4-hydroxynonenal in stress-mediated apoptosis signaling

    Yogesh C. Awasthi;Rajendra Sharma;J.Z. Cheng;Yusong Yang

  • Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling.

    Sharad S. Singhal;Sharda P. Singh;Preeti Singhal;David Horne

  • Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress.

    Ji-Zhong Cheng;Rajendra Sharma;Yusong Yang;Sharad S. Singhal

  • Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin.

    Sanjay Awasthi;Jizhong Cheng;Sharad S. Singhal;Manjit K. Saini

  • Curcumin protects against 4-hydroxy-2-trans-nonenal-induced cataract formation in rat lenses.

    S Awasthi;S K Srivatava;J T Piper;S S Singhal

  • Transfection of mGSTA4 in HL-60 cells protects against 4-hydroxynonenal-induced apoptosis by inhibiting JNK-mediated signaling.

    Ji-Zhong Cheng;Sharad S. Singhal;Abha Sharma;Manjit Saini

  • Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): a novel link between G-protein and tyrosine kinase signaling and drug resistance.

    Sanjay Awasthi;Sharad S. Singhal;Rajendra Sharma;Piotr Zimniak

  • Curcumin–glutathione interactions and the role of human glutathione S-transferase P1-1

    Sanjay Awasthi;Utpal Pandya;Sharad S. Singhal;James T. Lin

  • Adenosine triphosphate-dependent transport of doxorubicin, daunomycin, and vinblastine in human tissues by a mechanism distinct from the P-glycoprotein.

    S Awasthi;S S Singhal;S K Srivastava;P Zimniak

  • The Role of Human Glutathione S-Transferases hGSTA1-1 and hGSTA2-2 in Protection against Oxidative Stress

    Tiejun Zhao;Sharad S. Singhal;John T. Piper;Jizhong Cheng

  • Glutathione S-transferases of human lung: Characterization and evaluation of the protective role of the α-class isozymes against lipid peroxidation

    Sharad S. Singhal;Manju Saxena;Hassan Ahmad;Sanjay Awasthi

  • Regression of Lung and Colon Cancer Xenografts by Depleting or Inhibiting RLIP76 (Ral-Binding Protein 1)

    Sharad S. Singhal;Jyotsana Singhal;Sushma Yadav;Seema Dwivedi

  • Differential Catalytic Efficiency of Allelic Variants of Human GlutathioneS-Transferase Pi in Catalyzing the Glutathione Conjugation of Thiotepa

    Sanjay K. Srivastava;Sharad S. Singhal;Xun Hu;Yogesh C. Awasthi

  • Effects of mGST A4 transfection on 4-hydroxynonenal-mediated apoptosis and differentiation of K562 human erythroleukemia cells.

    Ji Zhong Cheng;Sharad S. Singhal;Manjit Saini;Jyotsana Singhal

  • Anti-cancer effects of novel flavonoid vicenin-2 as a single agent and in synergistic combination with docetaxel in prostate cancer.

    Lokesh Dalasanur Nagaprashantha;Rit Vatsyayan;Jyotsana Singhal;Spence Fast

Frequent Co-Authors

Yogesh C. Awasthi
Yogesh C. Awasthi University of North Texas Health Science Center
Sanjay Awasthi
Sanjay Awasthi Texas Tech University Health Sciences Center
Piotr Zimniak
Piotr Zimniak University of Arkansas for Medical Sciences
Sanjay K. Srivastava
Sanjay K. Srivastava Texas Tech University Health Sciences Center
Shivendra V. Singh
Shivendra V. Singh University of Pittsburgh
Satish K. Srivastava
Satish K. Srivastava The University of Texas Medical Branch at Galveston
Damir Janigro
Damir Janigro Case Western Reserve University
Istvan Boldogh
Istvan Boldogh The University of Texas Medical Branch at Galveston
Moulay A. Alaoui-Jamali
Moulay A. Alaoui-Jamali McGill University
Vsevolod L. Popov
Vsevolod L. Popov The University of Texas Medical Branch at Galveston

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring online programs can open up diverse pathways for biology and biochemistry enthusiasts. A sports science degree online offers insight into human physiology and physical performance—ideal for those interested in the intersection of biology, health, and physical activity.

Another growing field is kinesiology. By enrolling in an online bachelor's in kinesiology, students can deepen their understanding of movement and rehabilitation, paving the way for roles in fitness, wellness, or therapy.

For those already holding advanced degrees, pursuing the shortest pmhnp certificate program can lead to specialized careers in psychiatric mental health nursing. Similarly, completing online fnp programs enables advancement into family nurse practitioner roles with a biological and clinical focus.

Each of these online options offers flexible learning for those looking to expand their biology or biochemistry background into health, wellness, and clinical careers.

Best Scientists Citing Sharad S. Singhal

Trending Scientists