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Biology and Biochemistry

D-Index
108
Citations
59757
World Ranking
1030
National Ranking
623

Research.com Recognitions

  • 2002 - Member of the National Academy of Medicine (NAM)
  • 2001 - Canada Gairdner International Award
  • 1999 - Albert Lasker Award for Basic Medical Research, Lasker Foundation
  • 1998 - Fellow of the American Academy of Arts and Sciences
  • 1996 - Louisa Gross Horwitz Prize, Columbia University
  • 1992 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1986 - Member of the National Academy of Sciences

Overview

Bertil Hille is affiliated with the University of Washington in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Neuroscience. Within these disciplines, their focus areas include Molecular Biology, Cell Biology, Cellular and Molecular Neuroscience, Physiology, and Endocrine and Autonomic Systems.

The scientist's work addresses various main topics such as Cellular transport and secretion, Ion channel regulation and function, Receptor Mechanisms and Signaling, Erythrocyte Function and Pathophysiology, Lipid Membrane Structure and Behavior, Neuroscience and Neuropharmacology Research, and Protein Kinase Regulation and GTPase Signaling.

Among the venues frequently chosen for publication are the Proceedings of the National Academy of Sciences, The Journal of General Physiology, Biophysical Journal, Progress in Biophysics and Molecular Biology, and Annual Review of Biophysics. The most productive of these is the Proceedings of the National Academy of Sciences, with five publications.

Recent papers authored or co-authored by Bertil Hille include:

  • "Compartmentalization of phosphatidylinositol 4,5-bisphosphate metabolism into plasma membrane liquid-ordered/raft domains", 2021, Proceedings of the National Academy of Sciences
  • "Serotonin modulates melatonin synthesis as an autocrine neurotransmitter in the pineal gland", 2021, Proceedings of the National Academy of Sciences
  • "Ionic channels in nerve membranes, 50 years on", 2021, Progress in Biophysics and Molecular Biology
  • "A Pharmacological Analysis of the Ionic Channels of Nerve", 2025, Digital Commons - RU (Rockefeller University)
  • "Allosteric modulation of alternatively spliced Ca2+-activated Cl channels TMEM16A by PI(4,5)P2 and CaMKII", 2020, Proceedings of the National Academy of Sciences

The scientist has collaborated frequently with several researchers, including:

  • Byung-Chang Suh
  • Seung-Ryoung Jung
  • Duk-Su Koh
  • Jongyun Myeong
  • Lizbeth de la Cruz

The awards received by Bertil Hille over their career include membership in prestigious academies and notable scientific prizes such as:

  • Member of the National Academy of Sciences (1986)
  • Fellow of the American Association for the Advancement of Science (AAAS) (1992)
  • Louisa Gross Horwitz Prize, Columbia University (1996)
  • Fellow of the American Academy of Arts and Sciences (1998)
  • Albert Lasker Award for Basic Medical Research, Lasker Foundation (1999)
  • Canada Gairdner International Award (2001)
  • Member of the National Academy of Medicine (NAM) (2002)

Best Publications

  • Ionic channels of excitable membranes

    Bertil Hille

  • Ion Channels of Excitable Membranes

    Bertil Hille

  • Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

    Bertil Hille

  • Modulation of Ca2+ channels by G-protein beta gamma subunits.

    Stefan Herlitze;David E. Garcia;David E. Garcia;Ken Mackie;Bertil Hille

  • GTP-binding proteins couple cardiac muscarinic receptors to a K channel.

    Paul J. Pfaffinger;Jennifer M. Martin;Dale D. Hunter;Neil M. Nathanson

  • Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells.

    Ken Mackie;Bertil Hille

  • Potassium channels as multi-ion single-file pores.

    Bertil Hille;Wolfgang Schwarz

  • Modulation of ion-channel function by G-protein-coupled receptors

    Bertil Hille

  • GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

    Jane E. Lauckner;Jill B. Jensen;Huei Ying Chen;Hui Chen Lu

  • PIP2 is a necessary cofactor for ion channel function: how and why?

    Byung Chang Suh;Bertil Hille

  • Charges and Potentials at the Nerve Surface : Divalent ions and pH

    Bertil Hille

  • Mitochondrial Participation in the Intracellular Ca2+ Network

    Donner F. Babcock;James Herrington;Paul C. Goodwin;Young Bae Park

  • Negative surface charge near sodium channels of nerve: divalent ions, monovalent ions, and pH.

    B. Hille;Ann M. Woodhull;B. I. Shapiro

  • The Permeability of the Sodium Channel to Organic Cations in Myelinated Nerve

    Bertil Hille

  • Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis.

    Byung-Chang Suh;Bertil Hille

  • Light Scattering and Birefringence Changes during Nerve Activity

    L. B. Cohen;R. D. Keynes;Bertil Hille

  • Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate.

    Byung Chang Suh;Bertil Hille

  • The Selective Inhibition of Delayed Potassium Currents in Nerve by Tetraethylammonium Ion

    Bertil Hille

  • Ionic channels in nerve membranes.

    Bertil Hille

  • Pharmacological Modifications of the Sodium Channels of Frog Nerve

    Bertil Hille

Frequent Co-Authors

William A. Catterall
William A. Catterall University of Washington
Ken Mackie
Ken Mackie Indiana University
Neil M. Nathanson
Neil M. Nathanson University of Washington
David J. Beech
David J. Beech University of Leeds
Clay M. Armstrong
Clay M. Armstrong University of Pennsylvania
Clay M. Armstrong
Clay M. Armstrong University of Pennsylvania
Tao Xu
Tao Xu Chinese Academy of Sciences
Ruth E. Westenbroek
Ruth E. Westenbroek University of Washington
David J. Adams
David J. Adams Wellcome Sanger Institute
Kyong-Tai Kim
Kyong-Tai Kim Pohang University of Science and Technology

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