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Aristotelis Tsirigos

Aristotelis Tsirigos

D-Index & Metrics

Biology and Biochemistry

D-Index
81
Citations
27504
World Ranking
3832
National Ranking
1897

Overview

Aristotelis Tsirigos is a researcher affiliated with New York University in the United States. Their research spans primarily within the fields of Biochemistry, Genetics, and Molecular Biology, as well as Medicine. The scientist's work has resulted in a significant number of publications, with notable contributions in Molecular Biology, Oncology, Immunology, Cancer Research, and Radiology, Nuclear Medicine, and Imaging.

The primary research topics covered by Aristotelis Tsirigos include:

  • Epigenetics and DNA Methylation
  • Genomics and Chromatin Dynamics
  • Radiomics and Machine Learning in Medical Imaging
  • Cancer Genomics and Diagnostics
  • AI in cancer detection
  • Cancer Immunotherapy and Biomarkers
  • RNA modifications and cancer

Among their recent publications are the following papers:

  • Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis, 2020, Cancer Cell
  • Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture, 2020, Nature
  • Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment, 2023, Nature Communications
  • Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia, 2020, Nature Genetics
  • Interleukin-17 governs hypoxic adaptation of injured epithelium, 2022, Science

Frequent co-authors who have collaborated extensively with Aristotelis Tsirigos include:

  • Iannis Aifantis
  • Nicolas Coudray
  • Alireza Khodadadi-Jamayran
  • Igor Dolgalev
  • Andreas Kloetgen

Their publications appear regularly in several scientific venues. The most frequent publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood
  • Nature Communications
  • Cancer Research
  • Clinical Cancer Research

Best Publications

  • DNA methylation-based classification of central nervous system tumours

    David Capper;David Capper;David Capper;David T. W. Jones;Martin Sill;Volker Hovestadt

  • Classification and mutation prediction from non-small cell lung cancer histopathology images using deep learning.

    Nicolas Coudray;Paolo Santiago Ocampo;Theodore Sakellaropoulos;Navneet Narula

  • Dynamic changes in the human methylome during differentiation

    Louise Laurent;Eleanor Wong;Guoliang Li;Tien Huynh

  • The bone marrow microenvironment at single-cell resolution.

    Anastasia N. Tikhonova;Igor Dolgalev;Hai Hu;Kishor K Sivaraj

  • Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism

    Gloria Bonuccelli;Aristotelis Tsirigos;Diana Whitaker-Menezes;Stephanos Pavlides

  • Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

    Luisa Cimmino;Igor Dolgalev;Yubao Wang;Akihide Yoshimi

  • Accurate phylogenetic classification of variable-length DNA fragments

    Alice Carolyn McHardy;Héctor García Martín;Aristotelis Tsirigos;Philip Hugenholtz

  • Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

    Panagiotis Ntziachristos;Panagiotis Ntziachristos;Aristotelis Tsirigos;Pieter Van Vlierberghe;Jelena Nedjic

  • Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1

    Luca Lignitto;Sarah E. LeBoeuf;Harrison Homer;Shaowen Jiang

  • Genome-wide Mapping and Characterization of Notch-Regulated Long Noncoding RNAs in Acute Leukemia

    Thomas Trimarchi;Thomas Trimarchi;Erhan Bilal;Panagiotis Ntziachristos;Panagiotis Ntziachristos;Giulia Fabbri

  • Ketones and lactate increase cancer cell “stemness”, driving recurrence, metastasis and poor clinical outcome in breast cancer: Achieving personalized medicine via metabolo-genomics

    Ubaldo E. Martinez-Outschoorn;Marco Prisco;Adam Ertel;Aristotelis Tsirigos

  • Airway Microbiota Is Associated with Upregulation of the PI3K Pathway in Lung Cancer.

    Jun Chieh J. Tsay;Benjamin G. Wu;Michelle H. Badri;Jose C. Clemente

  • Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia

    Panagiotis Ntziachristos;Panagiotis Ntziachristos;Aristotelis Tsirigos;G. Grant Welstead;Thomas Trimarchi

  • Multipath routing in the presence of frequent topological changes

    A. Tsirigos;Z.J. Haas

  • Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: Visualizing the therapeutic effects of metformin in tumor tissue

    Diana Whitaker-Menezes;Ubaldo E. Martinez-Outschoorn;Neal Flomenberg;Ruth C. Birbe

  • Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation

    Stephanos Pavlides;Aristotelis Tsirigos;Iset Vera;Neal Flomenberg

  • The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism

    Stephanos Pavlides;Aristotelis Tsirigos;Gemma Migneco;Diana Whitaker-Menezes

  • CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance

    Lauren A. Pitt;Anastasia N. Tikhonova;Hai Hu;Thomas Trimarchi

  • Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production.

    Claudia Capparelli;Carmela Guido;Diana Whitaker-Menezes;Gloria Bonuccelli

  • Genome-wideMappingandCharacterization of Notch-Regulated Long Noncoding RNAs in Acute Leukemia

    Thomas Trimarchi;Erhan Bilal;Panagiotis Ntziachristos;Giulia Fabbri

Frequent Co-Authors

Iannis Aifantis
Iannis Aifantis New York University
Adriana Heguy
Adriana Heguy New York University
Federica Sotgia
Federica Sotgia University of Salford
Isidore Rigoutsos
Isidore Rigoutsos Thomas Jefferson University
Michael P. Lisanti
Michael P. Lisanti University of Salford
Jane A. Skok
Jane A. Skok New York University
Anthony Howell
Anthony Howell University of Manchester
Richard G. Pestell
Richard G. Pestell The Wistar Institute
Diana Whitaker-Menezes
Diana Whitaker-Menezes Thomas Jefferson University
David Zagzag
David Zagzag New York University

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