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Medicine

D-Index
89
Citations
48426
World Ranking
12429
National Ranking
6363

Overview

David M. Hyman is affiliated with Memorial Sloan Kettering Cancer Center in the United States. Their research spans the fields of medicine and biochemistry, genetics, and molecular biology, with a significant focus on pulmonary and respiratory medicine, oncology, molecular biology, cancer research, and pathology and forensic medicine.

The scientist's work covers several main topics related to cancer biology and treatment. These include cancer genomics and diagnostics, lung cancer treatments and mutations, PI3K/AKT/mTOR signaling in cancer, HER2/EGFR in cancer research, colorectal cancer treatments and studies, advanced breast cancer therapies, and pancreatic and hepatic oncology research.

David M. Hyman has published extensively, contributing to multiple articles in prominent journals. Their frequent publication venues include:

  • Cancer Research
  • Clinical Cancer Research
  • Cancer Discovery
  • Nature Communications
  • Annals of Oncology

They have coauthored work with several researchers, most notably:

  • Alexander Drilon
  • David B. Solit
  • Alison M. Schram
  • Barry S. Taylor
  • Marc Ladanyi

Selected recent papers authored or coauthored by David M. Hyman highlight a range of oncology-focused clinical and molecular research topics. These include:

  • Larotrectinib in patients with TRK fusion-positive solid tumours: a pooled analysis of three phase 1/2 clinical trials, 2020, The Lancet Oncology
  • Cancer therapy shapes the fitness landscape of clonal hematopoiesis, 2020, Nature Genetics
  • Small molecules, big impact: 20 years of targeted therapy in oncology, 2020, The Lancet
  • HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers, 2020, Cancer Discovery
  • OncoTree: A Cancer Classification System for Precision Oncology, 2021, JCO Clinical Cancer Informatics

Best Publications

  • Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

    Ahmet Zehir;Ryma Benayed;Ronak H Shah;Aijazuddin Syed

  • Efficacy of Larotrectinib in TRK Fusion–Positive Cancers in Adults and Children

    Alexander Drilon;Theodore W. Laetsch;Shivaani Kummar;Steven G. DuBois

  • OncoKB: A Precision Oncology Knowledge Base.

    Debyani Chakravarty;Jianjiong Gao;Sarah Phillips;Ritika Kundra

  • A view on drug resistance in cancer

    Neil Vasan;Neil Vasan;José Baselga;José Baselga;José Baselga;David M. Hyman;David M. Hyman

  • AACR project genie: Powering precision medicine through an international consortium

    S. M. Sweeney;E. Cerami;A. Baras;T. J. Pugh

  • Vemurafenib in Multiple Nonmelanoma Cancers with BRAF V600 Mutations

    David M. Hyman;Igor Puzanov;Vivek Subbiah;Jason E. Faris

  • Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy

    Diego Chowell;Luc G. T. Morris;Claud M. Grigg;Jeffrey K. Weber

  • The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers.

    Pedram Razavi;Matthew T. Chang;Guotai Xu;Chaitanya Bandlamudi

  • Larotrectinib in patients with TRK fusion-positive solid tumours: a pooled analysis of three phase 1/2 clinical trials

    David S Hong;Steven G DuBois;Shivaani Kummar;Anna F Farago

  • Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer

    Rona Yaeger;Walid K. Chatila;Marla D. Lipsyc;Jaclyn F. Hechtman

  • HER kinase inhibition in patients with HER2- and HER3-mutant cancers.

    David M. Hyman;Sarina A. Piha-Paul;Helen Won;Jordi Rodon

  • Therapy-Related Clonal Hematopoiesis in Patients with Non-hematologic Cancers Is Common and Associated with Adverse Clinical Outcomes.

    Catherine C. Coombs;Ahmet Zehir;Sean M. Devlin;Ashwin Kishtagari

  • Consensus guidelines for the diagnosis and clinical management of Erdheim-Chester disease

    Eli L. Diamond;Lorenzo Dagna;David M. Hyman;Giulio Cavalli

  • Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies.

    Emmet J. Jordan;Hyunjae R. Kim;Maria E. Arcila;David Barron

  • High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants.

    Pedram Razavi;Bob T. Li;David N. Brown;Byoungsok Jung

  • Genome doubling shapes the evolution and prognosis of advanced cancers

    Craig M Bielski;Ahmet Zehir;Alexander V Penson;Mark T A Donoghue

  • Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer

    Alicia Latham;Preethi Srinivasan;Yelena Kemel;Jinru Shia

  • Cancer therapy shapes the fitness landscape of clonal hematopoiesis

    Kelly L. Bolton;Ryan N. Ptashkin;Teng Gao;Lior Braunstein

  • Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making.

    Wassim Abida;Joshua Armenia;Anuradha Gopalan;Ryan Brennan

  • Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next Generation Sequencing for Matching Patients to Targeted and Immune Therapies

    James J Harding;Subhiksha Nandakumar;Joshua Armenia;Danny N Khalil

Frequent Co-Authors

David B. Solit
David B. Solit Memorial Sloan Kettering Cancer Center
Michael F. Berger
Michael F. Berger Memorial Sloan Kettering Cancer Center
Ahmet Zehir
Ahmet Zehir Natera (United States)
Alexander Drilon
Alexander Drilon Memorial Sloan Kettering Cancer Center
Marc Ladanyi
Marc Ladanyi Memorial Sloan Kettering Cancer Center
José Baselga
José Baselga Memorial Sloan Kettering Cancer Center
Maria E. Arcila
Maria E. Arcila Memorial Sloan Kettering Cancer Center
Barry S. Taylor
Barry S. Taylor Memorial Sloan Kettering Cancer Center
Carol Aghajanian
Carol Aghajanian Memorial Sloan Kettering Cancer Center
Mark E. Robson
Mark E. Robson Memorial Sloan Kettering Cancer Center

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