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D-Index & Metrics

Biology and Biochemistry

D-Index
82
Citations
43254
World Ranking
3610
National Ranking
1805

Overview

Ahmet Zehir is affiliated with Natera in the United States and has contributed extensively to research in medicine, with a strong emphasis on cancer genomics and diagnostics. Their work spans multiple fields including biochemistry, genetics, and molecular biology.

The scientist's primary research interests include cancer genomics and diagnostics, genetic factors in colorectal cancer, acute myeloid leukemia research, lung cancer treatments and mutations, genomics and rare diseases, cancer immunotherapy and biomarkers, and sarcoma diagnosis and treatment.

Ahmet Zehir has published frequently in several notable scientific journals. These publication venues include:

  • Cancer Research
  • Journal of Clinical Oncology
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Molecular Diagnostics

Their recent papers cover topics related to cancer therapy, clonal hematopoiesis, metastatic patterns, and tumor mutational burden, among others. Selected recent publications include:

  • Cancer therapy shapes the fitness landscape of clonal hematopoiesis, 2020, Nature Genetics
  • Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients, 2022, Cell
  • Single-cell mutation analysis of clonal evolution in myeloid malignancies, 2020, Nature
  • Establishing guidelines to harmonize tumor mutational burden (TMB): in silico assessment of variation in TMB quantification across diagnostic platforms: phase I of the Friends of Cancer Research TMB Harmonization Project, 2020, Journal for ImmunoTherapy of Cancer
  • Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors, 2021, Nature Communications

The scientist collaborates frequently with a number of co-authors, including:

  • Michael F. Berger
  • Marc Ladanyi
  • David B. Solit
  • Ryma Benayed
  • Ryan Ptashkin

Ahmet Zehir's research contributions are primarily situated in the integration of molecular biology and oncology to address complex issues in cancer diagnosis and treatment. Specific subfields within their work include cancer research, molecular biology, oncology, pathology and forensic medicine, and pulmonary and respiratory medicine.

Best Publications

  • Tumor mutational load predicts survival after immunotherapy across multiple cancer types.

    Robert M Samstein;Chung-Han Lee;Chung-Han Lee;Alexander N Shoushtari;Alexander N Shoushtari;Matthew D Hellmann;Matthew D Hellmann

  • Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

    Ahmet Zehir;Ryma Benayed;Ronak H Shah;Aijazuddin Syed

  • Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology

    Donavan T. Cheng;Talia N. Mitchell;Ahmet Zehir;Ronak H. Shah

  • OncoKB: A Precision Oncology Knowledge Base.

    Debyani Chakravarty;Jianjiong Gao;Sarah Phillips;Ritika Kundra

  • Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer

    Colin C. Pritchard;Joaquin Mateo;Michael F. Walsh;Navonil De Sarkar

  • Molecular Determinants of Response to Anti-Programmed Cell Death (PD)-1 and Anti-Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non-Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing.

    Hira Rizvi;Francisco Sanchez-Vega;Konnor La;Walid Chatila

  • Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy

    Diego Chowell;Luc G. T. Morris;Claud M. Grigg;Jeffrey K. Weber

  • Variant Review with the Integrative Genomics Viewer

    James T. Robinson;Helga Thorvaldsdóttir;Aaron M. Wenger;Ahmet Zehir

  • The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers.

    Pedram Razavi;Matthew T. Chang;Guotai Xu;Chaitanya Bandlamudi

  • Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer

    Rona Yaeger;Walid K. Chatila;Marla D. Lipsyc;Jaclyn F. Hechtman

  • Therapy-Related Clonal Hematopoiesis in Patients with Non-hematologic Cancers Is Common and Associated with Adverse Clinical Outcomes.

    Catherine C. Coombs;Ahmet Zehir;Sean M. Devlin;Ashwin Kishtagari

  • Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies.

    Emmet J. Jordan;Hyunjae R. Kim;Maria E. Arcila;David Barron

  • Analysis of the Prevalence of Microsatellite Instability in Prostate Cancer and Response to Immune Checkpoint Blockade

    Wassim Abida;Michael L. Cheng;Joshua Armenia;Sumit Middha

  • Genome doubling shapes the evolution and prognosis of advanced cancers

    Craig M Bielski;Ahmet Zehir;Alexander V Penson;Mark T A Donoghue

  • Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer

    Alicia Latham;Preethi Srinivasan;Yelena Kemel;Jinru Shia

  • Cancer therapy shapes the fitness landscape of clonal hematopoiesis

    Kelly L. Bolton;Ryan N. Ptashkin;Teng Gao;Lior Braunstein

  • Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision Making.

    Wassim Abida;Joshua Armenia;Anuradha Gopalan;Ryan Brennan

  • Genetic diversity of tumors with mismatch repair deficiency influences anti–PD-1 immunotherapy response

    Rajarsi Mandal;Rajarsi Mandal;Robert M. Samstein;Ken Wing Lee;Jonathan J. Havel

  • Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing

    Diana Mandelker;Liying Zhang;Yelena Kemel;Yelena Kemel;Zsofia K. Stadler;Zsofia K. Stadler

  • NTRK fusion detection across multiple assays and 33,997 cases: diagnostic implications and pitfalls

    James P. Solomon;Irina Linkov;Andrea Rosado;Kerry Mullaney

Frequent Co-Authors

Michael F. Berger
Michael F. Berger Memorial Sloan Kettering Cancer Center
David B. Solit
David B. Solit Memorial Sloan Kettering Cancer Center
Marc Ladanyi
Marc Ladanyi Memorial Sloan Kettering Cancer Center
David M. Hyman
David M. Hyman Memorial Sloan Kettering Cancer Center
Maria E. Arcila
Maria E. Arcila Memorial Sloan Kettering Cancer Center
Nikolaus Schultz
Nikolaus Schultz Memorial Sloan Kettering Cancer Center
Mark E. Robson
Mark E. Robson Memorial Sloan Kettering Cancer Center
Ross L. Levine
Ross L. Levine Memorial Sloan Kettering Cancer Center
Barry S. Taylor
Barry S. Taylor Memorial Sloan Kettering Cancer Center
Kenneth Offit
Kenneth Offit Memorial Sloan Kettering Cancer Center

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