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Molecular Biology

D-Index
67
Citations
20506
World Ranking
1557
National Ranking
787

Research.com Recognitions

  • 2019 - Fellow of the American Academy of Arts and Sciences
  • 2019 - Member of the National Academy of Sciences
  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Cynthia Wolberger is affiliated with the Johns Hopkins University School of Medicine in the United States. The scientific work primarily falls within biochemistry, genetics, and molecular biology, with a significant focus on molecular biology. Other subfields of interest include genetics, oncology, plant science, and cell biology.

Research topics addressed in their publications cover a variety of specialized areas:

  • Ubiquitin and proteasome pathways
  • Genomics and chromatin dynamics
  • RNA modifications and cancer
  • DNA repair mechanisms
  • RNA and protein synthesis mechanisms
  • Cancer-related gene regulation
  • Cancer-related molecular pathways

The scientist has contributed to several journals and publication venues, with multiple works appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • EMPIAR dataset
  • Nature Structural & Molecular Biology
  • Journal of Biological Chemistry
  • Acta Crystallographica Section A Foundations and Advances

Recent scholarly articles include:

  • "Measuring DNA mechanics on the genome scale" (2020) published in Nature
  • "Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome" (2020) published in eLife
  • "Breaking the K48-chain: linking ubiquitin beyond protein degradation" (2024) published in Nature Structural & Molecular Biology
  • "How structural biology transformed studies of transcription regulation" (2021) published in Journal of Biological Chemistry
  • "Potent macrocycle inhibitors of the human SAGA deubiquitinating module" (2021) published in Cell Chemical Biology

Cynthia Wolberger has collaborated frequently with several researchers, including:

  • Nancy L. Craig
  • Carol W. Greider
  • Gisela Storz
  • Orna Cohen-Fix
  • Rachel Green

In addition to journal papers, the scientist has authored a book titled Molecular Biology, published by Oxford University Press in 2021.

Awards received include:

  • Member of the National Academy of Sciences (2019)
  • Fellow of the American Academy of Arts and Sciences (2019)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2009)

Best Publications

  • SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells

    Marcia C. Haigis;Raul Mostoslavsky;Kevin M. Haigis;Kamau Fahie

  • Nampt/PBEF/visfatin regulates insulin secretion in β cells as a systemic NAD biosynthetic enzyme

    Javier R. Revollo;Antje Körner;Kathryn F. Mills;Akiko Satoh

  • A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

    Jeffrey S. Smith;Carrie Baker Brachmann;Carrie Baker Brachmann;Ivana Celic;Margaret A. Kenna;Margaret A. Kenna

  • The Biochemistry of Sirtuins

    Anthony A. Sauve;Cynthia Wolberger;Vern L. Schramm;Jef D. Boeke

  • New insights into ubiquitin E3 ligase mechanism

    Christopher E Berndsen;Cynthia Wolberger

  • A standard reference frame for the description of nucleic acid base-pair geometry

    Wilma K Olson;Manju Bansal;Stephen K Burley;Richard E Dickerson

  • Crystal structure of a MATα2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions

    Cynthia Wolberger;Andrew K. Vershon;Beishan Liu;Alexander D. Johnson

  • Regulated nucleosome mobility and the histone code.

    Michael S Cosgrove;Jef D Boeke;Cynthia Wolberger

  • MECHANISM OF SIRTUIN INHIBITION BY NICOTINAMIDE: ALTERING THE NAD+ COSUBSTRATE SPECIFICITY OF A SIR2 ENZYME

    José L. Avalos;Katherine M. Bever;Cynthia Wolberger

  • Recognition of Specific DNA Sequences

    Colin W. Garvie;Cynthia Wolberger

  • Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation.

    Derek E. Piper;Adrian H. Batchelor;Ching Pin Chang;Michael L. Cleary

  • The Structure of GABPα/β: An ETS Domain- Ankyrin Repeat Heterodimer Bound to DNA

    Adrian H. Batchelor;Derek E. Piper;Fabienne Charles de la Brousse;Steven L. McKnight;Steven L. McKnight

  • Mms2–Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation

    Michael J Eddins;Candice M Carlile;Kamila M Gomez;Kamila M Gomez;Cecile M Pickart

  • Molecular Insights into Polyubiquitin Chain Assembly: Crystal Structure of the Mms2/Ubc13 Heterodimer

    Andrew P. VanDemark;Roseanne M. Hofmann;Colleen Tsui;Cecile M. Pickart

  • Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme.

    Tao Wang;Xiangbin Zhang;Poonam Bheda;Javier R. Revollo

  • Structure of a Sir2 Enzyme Bound to an Acetylated p53 Peptide.

    Jose L Avalos;Ivana Celic;Shabazz Muhammad;Michael S Cosgrove

  • Crystal Structure of the MATa1/MATα2 Homeodomain Heterodimer Bound to DNA

    Thomas Li;Martha R. Stark;Alexander D. Johnson;Cynthia Wolberger

  • The mechanism of OTUB1-mediated inhibition of ubiquitination.

    Reuven Wiener;Xiangbin Zhang;Tao Wang;Tao Wang;Cynthia Wolberger

  • How does the histone code work

    Michael S Cosgrove;Cynthia Wolberger

  • Structural basis for ligand-regulated oligomerization of AraC.

    Stephen M. Soisson;Stephen M. Soisson;Beth MacDougall-Shackleton;Beth MacDougall-Shackleton;Robert Schleif;Robert Schleif;Cynthia Wolberger;Cynthia Wolberger

Frequent Co-Authors

Jef D. Boeke
Jef D. Boeke New York University
Stephen C. Harrison
Stephen C. Harrison Harvard University
Ashraf Brik
Ashraf Brik Technion – Israel Institute of Technology
Michael J. Matunis
Michael J. Matunis Johns Hopkins University
Philip A. Cole
Philip A. Cole Brigham and Women's Hospital
Cecile M. Pickart
Cecile M. Pickart Johns Hopkins University
Alexander D. Johnson
Alexander D. Johnson University of California, San Francisco
Tim Formosa
Tim Formosa University of Utah
Mark Ptashne
Mark Ptashne Memorial Sloan Kettering Cancer Center
Giorgio Inghirami
Giorgio Inghirami Cornell University

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