World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
42
Citations
6075
World Ranking
19499
National Ranking
7950

Overview

Tim Formosa is affiliated with the University of Utah in the United States. Their research primarily focuses on the field of Biochemistry, Genetics and Molecular Biology, with a significant concentration in Molecular Biology. Their work spans various topics including Genomics and Chromatin Dynamics, RNA modifications and cancer, DNA Repair Mechanisms, RNA Research and Splicing, RNA and protein synthesis mechanisms, Innovations in Medical Education, and Ubiquitin and proteasome pathways.

Key recent publications by Tim Formosa include:

  • The role of FACT in managing chromatin: disruption, assembly, or repair? (2020), Nucleic Acids Research
  • Electron microscopy analysis of ATP-independent nucleosome unfolding by FACT (2022), Communications Biology
  • The interaction between the Spt6-tSH2 domain and Rpb1 affects multiple functions of RNA Polymerase II (2021), Nucleic Acids Research
  • Hmo1 Protein Affects the Nucleosome Structure and Supports the Nucleosome Reorganization Activity of Yeast FACT (2022), Cells
  • Mechanism of curaxin-dependent nucleosome unfolding by FACT (2022), Frontiers in Molecular Biosciences

Frequent co-authors collaborating with Tim Formosa include:

  • Anastasiia L. Sivkina
  • М. П. Кирпичников
  • Vasily M. Studitsky
  • Maria E. Valieva
  • Laura McCullough

The scientist has published repeatedly in several key venues, such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nucleic Acids Research
  • Communications Biology
  • Cells
  • Frontiers in Molecular Biosciences

Tim Formosa's considerable contributions span the study of chromatin dynamics and nucleosome behavior, RNA processes, and mechanisms involved in DNA repair and protein synthesis. Their collaborations and publications highlight a sustained research interest in understanding molecular mechanisms related to gene expression and chromatin regulation.

Best Publications

  • DNA synthesis dependent on genetic recombination: Characterization of a reaction catalyzed by purified bacteriophage T4 proteins

    Timothy Formosa;Bruce M. Alberts

  • Spt16–Pob3 and the HMG protein Nhp6 combine to form the nucleosome‐binding factor SPN

    Tim Formosa;Peter Eriksson;Jacqui Wittmeyer;Jennifer Ginn

  • Studies on DNA replication in the bacteriophage T4 in vitro system.

    B. M. Alberts;J. Barry;P. Bedinger;T. Formosa

  • The Saccharomyces cerevisiae DNA polymerase alpha catalytic subunit interacts with Cdc68/Spt16 and with Pob3, a protein similar to an HMG1-like protein.

    Jacqueline Wittmeyer;Tim Formosa

  • The Role of FACT in Making and Breaking Nucleosomes

    Tim Formosa

  • Defects in SPT16 or POB3 (yFACT) in saccharomyces cerevisiae cause dependence on the Hir/Hpc pathway: Polymerase passage may degrade chromatin structure

    Tim Formosa;Susan Ruone;Melissa D. Adams;Aileen E. Olsen

  • yFACT Induces Global Accessibility of Nucleosomal DNA without H2A-H2B Displacement

    Hua Xin;Shinya Takahata;Mary Blanksma;Laura McCullough

  • Affinity purification of bacteriophage T4 proteins essential for DNA replication and genetic recombination.

    Timothy Formosa;Rae Lyn Burke;Bruce M. Alberts

  • Purification and characterization of the T4 bacteriophage uvsX protein.

    T Formosa;B M Alberts

  • Spt16 and Pob3 of Saccharomyces cerevisiae Form an Essential, Abundant Heterodimer That Is Nuclear, Chromatin-Associated, and Copurifies with DNA Polymerase α

    Jacqueline Wittmeyer;Lisa Joss;Tim Formosa

  • Structure of a Blm10 Complex Reveals Common Mechanisms for Proteasome Binding and Gate Opening

    Kianoush Sadre-Bazzaz;Frank G. Whitby;Howard Robinson;Tim Formosa

  • The Structure of the yFACT Pob3-M Domain, Its Interaction with the DNA Replication Factor RPA, and a Potential Role in Nucleosome Deposition

    Andrew P. VanDemark;Mary Blanksma;Elliott Ferris;Annie Heroux

  • Dna2 mutants reveal interactions with Dna polymerase alpha and Ctf4, a Pol alpha accessory factor, and show that full Dna2 helicase activity is not essential for growth.

    Tim Formosa;Thalia Nittis

  • FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs

    David J. Kemble;Laura L. McCullough;Frank G. Whitby;Tim Formosa

  • POB3 is required for both transcription and replication in the yeast Saccharomyces cerevisiae.

    Mylynda B. Schlesinger;Tim Formosa

  • Evidence that POB1, a Saccharomyces cerevisiae protein that binds to DNA polymerase alpha, acts in DNA metabolism in vivo.

    Jeff Miles;Tim Formosa

  • The yeast FACT complex has a role in transcriptional initiation.

    Debabrata Biswas;Yaxin Yu;Matthew Prall;Tim Formosa

  • Large-scale ATP-independent nucleosome unfolding by a histone chaperone

    Maria E Valieva;Grigoriy A Armeev;Kseniya S Kudryashova;Kseniya S Kudryashova;Nadezhda S Gerasimova

  • Multiple Nhp6 molecules are required to recruit Spt16-Pob3 to form yFACT complexes and to reorganize nucleosomes.

    Susan Ruone;Alison R. Rhoades;Tim Formosa

  • Structural and Functional Analysis of the Spt16p N-terminal Domain Reveals Overlapping Roles of yFACT Subunits

    Andrew P. VanDemark;Hua Xin;Laura McCullough;Robert Rawlins

Frequent Co-Authors

Christopher P. Hill
Christopher P. Hill University of Utah
David J. Stillman
David J. Stillman University of Utah
Bruce Alberts
Bruce Alberts University of California, San Francisco
Cynthia Wolberger
Cynthia Wolberger Johns Hopkins University School of Medicine
Ashraf Brik
Ashraf Brik Technion – Israel Institute of Technology
Howard Robinson
Howard Robinson Brookhaven National Laboratory
Stephen Buratowski
Stephen Buratowski Harvard University
Paul D. Kaufman
Paul D. Kaufman University of Massachusetts Chan Medical School
Danesh Moazed
Danesh Moazed Harvard University
Fred Winston
Fred Winston Harvard University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Pursuing a degree in Biology or Biochemistry opens doors to many related healthcare and science careers. Increasingly, students are leveraging flexible online options to earn credentials and advance in fields closely allied with life sciences.

For those considering nursing, online associate rn programs allow you to start a registered nursing career and gain clinical knowledge remotely, making it possible to balance education with work or family commitments.

Interested in preventive health or wellness? A nutritionist degree online can be a valuable path, blending scientific study with practical, client-facing skills for careers in healthcare, fitness, and education.

Students aspiring to leadership roles might explore top cahme-accredited mha programs, which emphasize healthcare management and administration—key in hospitals, labs, and biotech companies.

Meanwhile, those seeking advanced clinical positions can consider online dnp programs without dissertation, which streamline the process for earning a Doctor of Nursing Practice degree, often without the traditional research component.

Best Scientists Citing Tim Formosa

Trending Scientists

Recently Published Articles