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Molecular Biology

D-Index
48
Citations
10718
World Ranking
2670
National Ranking
1301

Overview

Zhiguo Zhang is affiliated with Columbia University in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with notable contributions in Medicine. Within these broad disciplines, their subfields of study include Molecular Biology, Genetics, Cancer Research, Pulmonary and Respiratory Medicine, and Neurology.

The main research topics Zhiguo Zhang has explored encompass:

  • Genomics and Chromatin Dynamics
  • Epigenetics and DNA Methylation
  • Glioma Diagnosis and Treatment
  • DNA Repair Mechanisms
  • RNA modifications and cancer
  • Ferroptosis and cancer prognosis
  • CRISPR and Genetic Engineering

Zhiguo Zhang has published extensively in several scientific venues. The most frequent publication venues include:

  • Neuro-Oncology
  • Nature Communications
  • Science Advances
  • Molecular Cell
  • bioRxiv (Cold Spring Harbor Laboratory)

Some notable recent papers authored or co-authored by Zhiguo Zhang are:

  • "DNA polymerase α interacts with H3-H4 and facilitates the transfer of parental histones to lagging strands," Science Advances, 2020
  • "Focused Ultrasound-Mediated Blood-Brain Barrier Opening Increases Delivery and Efficacy of Etoposide for Glioblastoma Treatment," International Journal of Radiation Oncology*Biology*Physics, 2020
  • "Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism," Cell Metabolism, 2023
  • "Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas," Molecular Cell, 2022
  • "Mechanisms of chromatin-based epigenetic inheritance," Science China Life Sciences, 2022

Zhiguo Zhang frequently collaborates with several researchers, including:

  • Hong-Jian Wei
  • Cheng-Chia Wu
  • Xu Zhang
  • Zhiming Li
  • Jovana Pavisic

Best Publications

  • Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map

    Sean R. Collins;Kyle M. Miller;Nancy L. Maas;Assen Roguev

  • The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression.

    Kui Ming Chan;Dong Fang;Haiyun Gan;Rintaro Hashizume

  • Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assembly.

    Qing Li;Hui Zhou;Hugo Wurtele;Brian Davies

  • Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma

    Rintaro Hashizume;Noemi Andor;Yuichiro Ihara;Robin Lerner

  • Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication

    Junhong Han;Hui Zhou;Bruce Horazdovsky;Kangling Zhang

  • Histone chaperones in nucleosome assembly and human disease

    Rebecca J Burgess;Zhiguo Zhang

  • PCNA connects DNA replication to epigenetic inheritance in yeast

    Zhiguo Zhang;Kei Ichi Shibahara;Bruce Stillman

  • PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.

    Jayme L. Dahlin;J. Willem M. Nissink;Jessica M. Strasser;Subhashree Francis

  • Histone H3-K56 acetylation is important for genomic stability in mammals.

    Jian Yuan;Mintie Pu;Zhiguo Zhang;Zhenkun Lou

  • The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas.

    Dong Fang;Haiyun Gan;Jeong Heon Lee;Jing Han

  • A mechanism for preventing asymmetric histone segregation onto replicating DNA strands

    Chuanhe Yu;Haiyun Gan;Albert Serra-Cardona;Lin Zhang

  • A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma.

    Xiaoyue Chen;Minjie Zhang;Haiyun Gan;Heping Wang

  • A role for Gcn5 in replication-coupled nucleosome assembly.

    Rebecca J. Burgess;Hui Zhou;Junhong Han;Zhiguo Zhang

  • Acetylation of lysine 56 of histone H3 catalyzed by RTT109 and regulated by ASF1 is required for replisome integrity.

    Junhong Han;Hui Zhou;Zhizhong Li;Rui Ming Xu

  • Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall.

    Chuanhe Yu;Haiyun Gan;Junhong Han;Zhi Xiong Zhou

  • The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands.

    Haiyun Gan;Albert Serra-Cardona;Xu Hua;Hui Zhou

  • A Cul4 E3 Ubiquitin Ligase Regulates Histone Hand-Off during Nucleosome Assembly

    Junhong Han;Hui Zhang;Honglian Zhang;Zhiquan Wang

  • Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing

    Shengbing Huang;Hui Zhou;David Katzmann;Mark Hochstrasser

  • Structure and function of the BAH-containing domain of Orc1p in epigenetic silencing.

    Zhiguo Zhang;Mariko K. Hayashi;Olaf Merkel;Bruce Stillman

  • The Rtt109-Vps75 histone acetyltransferase complex acetylates non-nucleosomal histone H3.

    Junhong Han;Hui Zhou;Zhizhong Li;Rui Ming Xu

Frequent Co-Authors

Hui Zhou
Hui Zhou Sun Yat-sen University
Tamas Ordog
Tamas Ordog Mayo Clinic
Rui-Ming Xu
Rui-Ming Xu Chinese Academy of Sciences
Jann N. Sarkaria
Jann N. Sarkaria Mayo Clinic
Andrew H. Limper
Andrew H. Limper Mayo Clinic
Nalin Gupta
Nalin Gupta University of California, San Francisco
Bruce Stillman
Bruce Stillman Cold Spring Harbor Laboratory
Zhiming Li
Zhiming Li Central South University

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