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Chemistry

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59
Citations
10816
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10295
National Ranking
72

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61
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Overview

Ashraf Brik is affiliated with the Technion - Israel Institute of Technology in Israel. Their research focuses broadly on Biochemistry, Genetics, and Molecular Biology, with specific concentrations in Molecular Biology, Oncology, Organic Chemistry, Cell Biology, and Genetics.

The primary topics addressed in Ashraf Brik's work include:

  • Ubiquitin and proteasome pathways
  • Protein degradation and inhibitors
  • Peptidase inhibition and analysis
  • Chemical synthesis and analysis
  • Click chemistry and applications
  • Glycosylation and glycoproteins research
  • RNA interference and gene delivery

Recent publications by Ashraf Brik exemplify their research scope and include the following papers:

  • "The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag," 2021, Nature Communications
  • "General synthetic strategy for regioselective ultrafast formation of disulfide bonds in peptides and proteins," 2021, Nature Communications
  • "Enhanced Live-Cell Delivery of Synthetic Proteins Assisted by Cell-Penetrating Peptides Fused to DABCYL," 2021, Angewandte Chemie International Edition
  • "On-Demand Detachment of Succinimides on Cysteine to Facilitate (Semi)Synthesis of Challenging Proteins," 2020, Journal of the American Chemical Society
  • "Harnessing the power of transition metals in solid-phase peptide synthesis and key steps in the (semi)synthesis of proteins," 2021, Chemical Society Reviews

Ashraf Brik frequently publishes in specific scientific venues including:

  • Angewandte Chemie International Edition
  • Angewandte Chemie
  • Nature Communications
  • Journal of the American Chemical Society
  • Chemical Science

The scientist collaborates regularly with several coauthors, reflecting ongoing research partnerships. Frequent coauthors include:

  • Shaswati Mandal
  • Guy Mann
  • Ganga B. Vamisetti
  • Hiroaki Suga
  • Abhishek Saha

Best Publications

  • HIV-1 protease: mechanism and drug discovery

    Ashraf Brik;Chi-Huey Wong

  • Small molecules targeting severe acute respiratory syndrome human coronavirus

    Chung Yi Wu;Jia Tsrong Jan;Shiou Hwa Ma;Chin Jung Kuo

  • 1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors.

    Ashraf Brik;Jerry Alexandratos;Ying-Chuan Lin;John H. Elder

  • Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins

    Somasekhar Bondalapati;Muhammad Jbara;Ashraf Brik

  • A Copper(I)-Catalyzed 1,2,3-Triazole Azide−Alkyne Click Compound Is a Potent Inhibitor of a Multidrug-Resistant HIV-1 Protease Variant

    Michael J. Giffin;Holly Heaslet;Ashraf Brik;Ying-Chuan Lin

  • Highly efficient and chemoselective peptide ubiquitylation.

    K. S. Ajish Kumar;Mahmood Haj-Yahya;Diana Olschewski;Hilal A. Lashuel

  • Structural basis for histone H2B deubiquitination by the SAGA DUB module.

    Michael T. Morgan;Mahmood Haj-Yahya;Alison E. Ringel;Prasanthi Bandi

  • Total Chemical Synthesis of a 304 Amino Acid K48‐Linked Tetraubiquitin Protein

    K. S. Ajish Kumar;Sudhir N. Bavikar;Liat Spasser;Tal Moyal

  • RNF20 and USP44 Regulate Stem Cell Differentiation by Modulating H2B Monoubiquitylation

    Gilad Fuchs;Efrat Shema;Rita Vesterman;Eran Kotler

  • Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors.

    Ashraf Brik;John Muldoon;Ying-Chuan Lin;John H. Elder

  • The Size of the Proteasomal Substrate Determines Whether Its Degradation Will Be Mediated by Mono- Or Polyubiquitylation

    Nitzan Shabek;Yifat Herman-Bachinsky;Samuel Buchsbaum;Oded Lewinson

  • Total Chemical Synthesis of Di‐ubiquitin Chains

    K. S. Ajish Kumar;Liat Spasser;Lesly A. Erlich;Sudhir N. Bavikar

  • Efficient Palladium-Assisted One-Pot Deprotection of (Acetamidomethyl)Cysteine Following Native Chemical Ligation and/or Desulfurization To Expedite Chemical Protein Synthesis.

    Suman Kumar Maity;Muhammad Jbara;Shay Laps;Ashraf Brik

  • Protein Synthesis Assisted by Native Chemical Ligation at Leucine

    Ziv Harpaz;Peter Siman;K. S. Ajish Kumar;Ashraf Brik

  • Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology

    Mahmood Haj-Yahya;Bruno Fauvet;Yifat Herman-Bachinsky;Mirva Hejjaoui

  • Palladium in the Chemical Synthesis and Modification of Proteins

    Muhammad Jbara;Suman Kumar Maity;Ashraf Brik

  • Sugar-Assisted Glycopeptide Ligation

    Ashraf Brik;Yu-Ying Yang;Simon Ficht;Chi-Huey Wong

  • Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34.

    Peter Siman;Subramanian Vedhanarayanan Karthikeyan;Miroslav Nikolov;Wolfgang Fischle

  • Chemistry and Biology of the Ubiquitin Signal

    Liat Spasser;Ashraf Brik

  • The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag.

    Indrajit Sahu;Sachitanand M. Mali;Prasad Sulkshane;Cong Xu

  • N-methylcysteine-mediated total chemical synthesis of ubiquitin thioester.

    Lesly A. Erlich;K. S. Ajish Kumar;Mahmood Haj-Yahya;Philip E. Dawson

Frequent Co-Authors

Chi-Huey Wong
Chi-Huey Wong Scripps Research Institute
Aaron Ciechanover
Aaron Ciechanover Technion – Israel Institute of Technology
Ehud Keinan
Ehud Keinan Technion – Israel Institute of Technology
Hilal A. Lashuel
Hilal A. Lashuel École Polytechnique Fédérale de Lausanne
Cynthia Wolberger
Cynthia Wolberger Johns Hopkins University School of Medicine
Richard J. Payne
Richard J. Payne University of Sydney
John H. Elder
John H. Elder Scripps Research Institute
Philip E. Dawson
Philip E. Dawson Scripps Research Institute
Chung-Yi Wu
Chung-Yi Wu Academia Sinica
David Fushman
David Fushman University of Maryland, College Park

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