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Medicine

D-Index
101
Citations
48144
World Ranking
7847
National Ranking
4090

Overview

Gary W. Cline is affiliated with Yale University in the United States and has contributed extensively to research in medicine, biochemistry, genetics, and molecular biology. Their work spans several subfields including molecular biology, physiology, epidemiology, surgery, and endocrinology, diabetes, and metabolism.

Their research primarily focuses on liver disease diagnosis and treatment, diet and metabolism studies, and the intersection of diet, metabolism, and disease. Other major topics include metabolism related to diabetes and cancer, pancreatic function, lipid metabolism and biosynthesis, and peroxisome proliferator-activated receptors.

Frequent publication venues for their research include the journal Diabetes, with eight publications, followed by Proceedings of the National Academy of Sciences with three papers. They have also published in UNC Libraries, Cell Metabolism, and the Journal of Lipid Research.

Among their recent papers are:

  • Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease, 2020, Proceedings of the National Academy of Sciences
  • Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis, 2020, Nature
  • A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance, 2020, Cell Metabolism
  • Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis, 2022, Proceedings of the National Academy of Sciences
  • Metabolic control analysis of hepatic glycogen synthesis in vivo, 2020, Proceedings of the National Academy of Sciences

Collaboration is a significant aspect of their work. Frequent coauthors include Gerald I. Shulman, Ali Nasiri, Mario Kahn, Kitt Falk Petersen, and Leigh Goedeke, reflecting ongoing partnerships in their research endeavors.

Best Publications

  • Mitochondrial dysfunction in the elderly: possible role in insulin resistance

    Kitt Falk Petersen;Douglas Befroy;Sylvie Dufour;James Dziura

  • Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

    Oscar R. Colegio;Ngoc Quynh Chu;Alison L. Szabo;Thach Chu

  • Mechanism of free fatty acid-induced insulin resistance in humans.

    Michael Roden;Thomas B. Price;Gianluca Perseghin;Kitt Falk Petersen

  • Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle *

    Chunli Yu;Yan Chen;Gary W. Cline;Dongyan Zhang

  • Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activity

    Alan Dresner;Didier Laurent;Melissa Marcucci;Margaret E. Griffin

  • Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

    Margaret E. Griffin;Melissa J. Marcucci;Gary W. Cline;Kim Bell

  • Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

    Anila K. Madiraju;Derek M. Erion;Yasmeen Rahimi;Xian-Man Zhang

  • Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

    Rachel J. Perry;Liang Peng;Natasha A. Barry;Gary W. Cline

  • Increased Glucose Transport–Phosphorylation and Muscle Glycogen Synthesis after Exercise Training in Insulin-Resistant Subjects

    Gianluca Perseghin;Thomas B. Price;Kitt Falk Petersen;Michael Roden

  • Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

    Kitt Falk Petersen;Elif Arioglu Oral;Sylvie Dufour;Douglas Befroy

  • Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes.

    Gary W. Cline;Kitt Falk Petersen;Martin Krssak;Jun Shen

  • The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

    Kitt Falk Petersen;Sylvie Dufour;David B. Savage;Stefan Bilz

  • UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

    Zane B. Andrews;Zhong-Wu Liu;Nicholas Walllingford;Derek M. Erion

  • The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes

    Adam B. Mayerson;Ripudaman S. Hundal;Sylvie Dufour;Vincent Lebon

  • Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

    Rachel J. Perry;João Paulo G Camporez;Romy Kursawe;Paul M. Titchenell

  • Differential Effects of Interleukin-6 and -10 on Skeletal Muscle and Liver Insulin Action In Vivo

    Hyo-Jeong Kim;Takamasa Higashimori;So-Young Park;Hyejeong Choi

  • PKC-θ knockout mice are protected from fat-induced insulin resistance

    Jason K. Kim;Jonathan J. Fillmore;Mary Jean Sunshine;Bjoern Albrecht

  • Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

    Jie An;Deborah M Muoio;Masakazu Shiota;Yuka Fujimoto

  • Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism.

    Vincent Lebon;Kitt F. Petersen;Gary W. Cline;Jun Shen

  • Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2

    David B. Savage;Cheol Soo Choi;Varman T. Samuel;Zhen-Xiang Liu

Frequent Co-Authors

Gerald I. Shulman
Gerald I. Shulman Yale University
Kitt Falk Petersen
Kitt Falk Petersen Yale University
Douglas L. Rothman
Douglas L. Rothman Yale University
Richard E. Carson
Richard E. Carson Yale University
Graeme F. Mason
Graeme F. Mason Yale University
Robert S. Sherwin
Robert S. Sherwin Yale University
Jason K. Kim
Jason K. Kim University of Massachusetts Chan Medical School
Mika Naganawa
Mika Naganawa Yale University
Michael Roden
Michael Roden Heinrich Heine University Düsseldorf
Nabeel Nabulsi
Nabeel Nabulsi Yale University

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