D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 104 Citations 31,699 225 World Ranking 890 National Ranking 561

Research.com Recognitions

Awards & Achievements

2010 - Fellow of the American Association for the Advancement of Science (AAAS)

2003 - Fellow of the American Academy of Arts and Sciences

1996 - Member of the National Academy of Sciences

1982 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • DNA

William Wickner focuses on Cell biology, Biochemistry, Membrane protein, Vacuole fusion and Lipid bilayer fusion. His Cell biology course of study focuses on SNARE complex assembly and CORVET complex. His Biochemistry research focuses on Biophysics and how it connects with Chaperone.

His Membrane protein research is multidisciplinary, relying on both Protein structure, Protein subunit and Translocase. His Vacuole study combines topics from a wide range of disciplines, such as Vacuole inheritance and Saccharomyces cerevisiae. His work on Biological membrane and Peripheral membrane protein as part of general Membrane research is frequently linked to Transmembrane protein, bridging the gap between disciplines.

His most cited work include:

  • Multiple mechanisms of protein insertion into and across membranes. (563 citations)
  • Sec18p (NSF)-Driven Release of Sec17p (α-SNAP) Can Precede Docking and Fusion of Yeast Vacuoles (525 citations)
  • SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion (493 citations)

What are the main themes of his work throughout his whole career to date?

William Wickner mainly investigates Biochemistry, Cell biology, Vacuole, Lipid bilayer fusion and Membrane protein. William Wickner works mostly in the field of Biochemistry, limiting it down to topics relating to Biophysics and, in certain cases, Chromosomal translocation. William Wickner brings together Cell biology and Vacuole fusion to produce work in his papers.

William Wickner focuses mostly in the field of Vacuole, narrowing it down to topics relating to Vacuole inheritance and, in certain cases, Cell division. His Lipid bilayer fusion research includes themes of Transport protein, Tethering and PX domain. His Membrane protein study incorporates themes from Adenosine triphosphate and Signal peptide.

He most often published in these fields:

  • Biochemistry (51.35%)
  • Cell biology (50.45%)
  • Vacuole (32.88%)

What were the highlights of his more recent work (between 2010-2021)?

  • Lipid bilayer fusion (31.53%)
  • Cell biology (50.45%)
  • Vacuole (32.88%)

In recent papers he was focusing on the following fields of study:

William Wickner mainly focuses on Lipid bilayer fusion, Cell biology, Vacuole, Biophysics and Rab. His work on SNARE complex assembly and SNARE complex as part of general Lipid bilayer fusion research is frequently linked to Transmembrane protein, thereby connecting diverse disciplines of science. His Cell biology research is multidisciplinary, incorporating perspectives in Membrane protein and Protein targeting.

His Protein targeting study necessitates a more in-depth grasp of Biochemistry. A large part of his Biochemistry studies is devoted to Vesicle-associated membrane protein 8. He connects Vacuole with Vacuole fusion in his research.

Between 2010 and 2021, his most popular works were:

  • A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly (162 citations)
  • Membranes linked by trans-SNARE complexes require lipids prone to non-bilayer structure for progression to fusion (64 citations)
  • A cascade of multiple proteins and lipids catalyzes membrane fusion. (43 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • DNA

The scientist’s investigation covers issues in Lipid bilayer fusion, Cell biology, Membrane, Vacuole and Plasma protein binding. His Lipid bilayer fusion study contributes to a more complete understanding of Biochemistry. The various areas that William Wickner examines in his Cell biology study include SNARE complex assembly, Protein subunit and Membrane protein.

While the research belongs to areas of Membrane, William Wickner spends his time largely on the problem of Tethering, intersecting his research to questions surrounding Compartment, In vitro and Biotinylation. William Wickner combines subjects such as Liposome, SNARE complex disassembly, Biophysics, Cell membrane and Lipid bilayer with his study of Plasma protein binding. Within one scientific family, he focuses on topics pertaining to Membrane lipids under Rab, and may sometimes address concerns connected to GTP' and Vesicular transport protein.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Multiple mechanisms of protein insertion into and across membranes.

William T. Wickner;Harvey F. Lodish.
Science (1985)

888 Citations

Sec18p (NSF)-Driven Release of Sec17p (α-SNAP) Can Precede Docking and Fusion of Yeast Vacuoles

Andreas Mayer;William Wickner;Albert Haas.
Cell (1996)

816 Citations

SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion

Anastassios Economou;William Wickner.
Cell (1994)

767 Citations

The binding cascade of SecB to SecA to SecY/E mediates preprotein targeting to the E. coli plasma membrane.

Franz-Ulrich Hartl;Stewart Lecker;Elmar Schiebel;Joseph P. Hendrick.
Cell (1990)

740 Citations

The ATPase activity of secA is regulated by acidic phospholipids, secY, and the leader and mature domains of precursor proteins

Roland Lill;William Dowhan;William Wickner.
Cell (1990)

651 Citations

The purified E. coli integral membrane protein SecY/E is sufficient for reconstitution of SecA-dependent precursor protein translocation.

Lorna Brundage;Joseph P. Hendrick;Elmar Schiebel;Arnold J.M. Driessen.
Cell (1990)

623 Citations

A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion

Darren F. Seals;Gary Eitzen;Nathan Margolis;William T. Wickner.
Proceedings of the National Academy of Sciences of the United States of America (2000)

619 Citations

Protein Translocation Across Biological Membranes

William Wickner;Randy Schekman.
Science (2005)

583 Citations

ΔμH+ and ATP function at different steps of the catalytic cycle of preprotein translocase

Elmar Schiebel;Arnold J.M. Driessen;Franz-Ulrich Hartl;William Wickner.
Cell (1991)

567 Citations

The enzymology of protein translocation across the Escherichia coli plasma membrane.

William Wickner;Arnold J.M. Driessen;Franz-Ulrich Hartl.
Annual Review of Biochemistry (1991)

531 Citations

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