World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
107
Citations
33987
World Ranking
1120
National Ranking
671

Research.com Recognitions

  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2003 - Fellow of the American Academy of Arts and Sciences
  • 1996 - Member of the National Academy of Sciences
  • 1982 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

William Wickner is affiliated with Dartmouth College in the United States. Their research primarily focuses on the fields of biochemistry, genetics, and molecular biology, with a particular emphasis on cell biology and molecular biology. Additional subfields include physiology, genetics, and signal processing.

The scientist's work covers several main topics, including cellular transport and secretion, lipid membrane structure and behavior, endoplasmic reticulum stress and disease, calcium signaling and nucleotide metabolism, signaling pathways in disease, biochemical and structural characterization, and bacterial genetics and biotechnology.

Wickner has contributed to multiple papers published in various scientific venues. Notable recent papers include:

  • HOPS recognizes each SNARE, assembling ternary trans-complexes for rapid fusion upon engagement with the 4th SNARE (2020, eLife)
  • Sec17/Sec18 can support membrane fusion without help from completion of SNARE zippering (2021, eLife)
  • Asymmetric Rab activation of vacuolar HOPS to catalyze SNARE complex assembly (2020, Molecular Biology of the Cell)
  • Phosphatidylinositol and phosphatidylinositol-3-phosphate activate HOPS to catalyze SNARE assembly, allowing small headgroup lipids to support the terminal steps of membrane fusion (2021, Molecular Biology of the Cell)
  • Fusion with wild-type SNARE domains is controlled by juxtamembrane domains, transmembrane anchors, and Sec17 (2022, Molecular Biology of the Cell)

Frequent publication venues for their work include:

  • Molecular Biology of the Cell
  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • Biophysical Journal
  • Proceedings of the National Academy of Sciences

William Wickner collaborates with multiple researchers, with frequent co-authors being:

  • Amy Orr
  • Hongki Song
  • Axel T. Brünger
  • Karina Letícia Lopes
  • Thomas Torng

The scientist has been recognized with several awards, including:

  • Fellow of the American Association for the Advancement of Science (AAAS) in 2010
  • Fellow of the American Academy of Arts and Sciences in 2003
  • Member of the National Academy of Sciences in 1996
  • Fellow of John Simon Guggenheim Memorial Foundation in 1982

Best Publications

  • Multiple mechanisms of protein insertion into and across membranes.

    William T. Wickner;Harvey F. Lodish

  • The binding cascade of SecB to SecA to SecY/E mediates preprotein targeting to the E. coli plasma membrane.

    Franz-Ulrich Hartl;Stewart Lecker;Elmar Schiebel;Joseph P. Hendrick

  • SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion

    Anastassios Economou;William Wickner

  • Sec18p (NSF)-Driven Release of Sec17p (α-SNAP) Can Precede Docking and Fusion of Yeast Vacuoles

    Andreas Mayer;William Wickner;Albert Haas

  • The ATPase activity of secA is regulated by acidic phospholipids, secY, and the leader and mature domains of precursor proteins

    Roland Lill;William Dowhan;William Wickner

  • The purified E. coli integral membrane protein SecY/E is sufficient for reconstitution of SecA-dependent precursor protein translocation.

    Lorna Brundage;Joseph P. Hendrick;Elmar Schiebel;Arnold J.M. Driessen

  • A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion

    Darren F. Seals;Gary Eitzen;Nathan Margolis;William T. Wickner

  • Protein Translocation Across Biological Membranes

    William Wickner;Randy Schekman

  • ΔμH+ and ATP function at different steps of the catalytic cycle of preprotein translocase

    Elmar Schiebel;Arnold J.M. Driessen;Franz-Ulrich Hartl;William Wickner

  • The enzymology of protein translocation across the Escherichia coli plasma membrane.

    William Wickner;Arnold J.M. Driessen;Franz-Ulrich Hartl

  • Homotypic vacuolar fusion mediated by t- and v-SNAREs

    Benjamin J. Nichols;Christian Ungermann;Hugh R. B. Pelham;William T. Wickner

  • The Assembly of Proteins into Biological Membranes: The Membrane Trigger Hypothesis

    William Wickner

  • SecA protein hydrolyzes ATP and is an essential component of the protein translocation ATPase of Escherichia coli.

    R. Lill;K. Cunningham;L. A. Brundage;K. Ito

  • Three pure chaperone proteins of Escherichia coli--SecB, trigger factor and GroEL--form soluble complexes with precursor proteins in vitro.

    Lecker S;Lill R;Ziegelhoffer T;Georgopoulos C

  • SecA membrane cycling at SecYEG is driven by distinct ATP binding and hydrolysis events and is regulated by SecD and SecF

    Anastassios Economou;Joseph A. Pogliano;Jonathan Beckwith;Donald B. Oliver

  • RNA Synthesis Initiates In Vitro Conversion of M13 DNA to Its Replicative Form

    William Wickner;Douglas Brutlag;Randy Schekman;Arthur Kornberg

  • Leader peptidase catalyzes the release of exported proteins from the outer surface of the Escherichia coli plasma membrane.

    R E Dalbey;W Wickner

  • Defining the functions of trans -SNARE pairs

    Christian Ungermann;Ken Sato;Ken Sato;William Wickner

  • Sequence of the leader peptidase gene of Escherichia coli and the orientation of leader peptidase in the bacterial envelope.

    P B Wolfe;W Wickner;J M Goodman

  • Distinct catalytic roles of the SecYE, SecG and SecDFyajC subunits of preprotein translocase holoenzyme.

    Franck Duong;William Wickner

Frequent Co-Authors

Christian Ungermann
Christian Ungermann Osnabrück University
Koreaki Ito
Koreaki Ito Kyoto Sangyo University
Arnold J. M. Driessen
Arnold J. M. Driessen University of Groningen
Colin Watts
Colin Watts University of Birmingham
Ross E. Dalbey
Ross E. Dalbey The Ohio State University
Lois S. Weisman
Lois S. Weisman University of Michigan–Ann Arbor
Pamela A. Silver
Pamela A. Silver Harvard University
Arthur Kornberg
Arthur Kornberg Stanford University
Ken Sato
Ken Sato Gunma University
Randy Schekman
Randy Schekman University of California, Berkeley

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