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Biology and Biochemistry

D-Index
59
Citations
11903
World Ranking
12591
National Ranking
5379

Research.com Recognitions

  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Lois S. Weisman is affiliated with the University of Michigan-Ann Arbor in the United States. Their research primarily focuses on the areas of biochemistry, genetics, and molecular biology, with significant contributions to medicine. The main subfields of study include molecular biology, cell biology, cellular and molecular neuroscience, epidemiology, and physiology.

Their work covers several key topics, notably cellular transport and secretion, autophagy in disease and therapy, calcium signaling and nucleotide metabolism, fungal and yeast genetics research, cardiomyopathy and myosin studies, genetic neurodegenerative diseases, and neuroscience and neuropharmacology research.

Lois S. Weisman's recent publications demonstrate sustained research activity in molecular and cellular biology. Significant papers include:

  • "Insights into Lysosomal PI(3,5)P2 Homeostasis from a Structural-Biochemical Analysis of the PIKfyve Lipid Kinase Complex" (2020), published in Molecular Cell
  • "Roles of PIKfyve in multiple cellular pathways" (2022), published in Current Opinion in Cell Biology
  • "Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate retriever-mediated recycling on endosomes" (2022), published in eLife
  • "PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity" (2022), published in Molecular Biology of the Cell
  • "Elevating PI3P drives select downstream membrane trafficking pathways" (2020), published in Molecular Biology of the Cell

Frequent co-authors working alongside Lois S. Weisman include Pilar Rivero-Ríos, Sai Srinivas Panapakkam Giridharan, Michael A. Sutton, Tunahan Uygun, and Garrett D. Chavis. Collaboration with these researchers reflects a networked approach to the study of cellular and molecular processes.

Their work has been published repeatedly in several venues known for research in cellular and molecular biology. These include bioRxiv (Cold Spring Harbor Laboratory), Molecular Biology of the Cell, The Journal of Cell Biology, Current Opinion in Cell Biology, and Current Biology.

Recognition of their contributions includes election as a Fellow of the American Association for the Advancement of Science (AAAS) in 2011.

Best Publications

  • PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

    Xian Ping Dong;Dongbiao Shen;Xiang Wang;Taylor Dawson

  • Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis

    Jonathan D. Gary;Andrew E. Wurmser;Cecilia J. Bonangelino;Lois S. Weisman

  • Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J

    Clement Y. Chow;Yanling Zhang;James J. Dowling;Natsuko Jin

  • Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS

    Clement Y. Chow;John E. Landers;John E. Landers;Sarah K. Bergren;Peter C. Sapp;Peter C. Sapp;Peter C. Sapp

  • Osmotic stress–induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p

    Cecilia J. Bonangelino;Johnathan J. Nau;Jason E. Duex;Mikala Brinkman

  • A TRP Channel in the Lysosome Regulates Large Particle Phagocytosis via Focal Exocytosis

    Mohammad Samie;Xiang Wang;Xiaoli Zhang;Andrew Goschka

  • VAC14 Nucleates a Protein Complex Essential for the Acute Interconversion of PI3P and PI(3,5)P2 in Yeast and Mouse

    Natsuko Jin;Clement Y Chow;Li Liu;Sergey N Zolov

  • Multiple methods of visualizing the yeast vacuole permit evaluation of its morphology and inheritance during the cell cycle.

    Lois S. Weisman;Robert Bacallao;William Wickner

  • ACTIN AND MYOSIN FUNCTION IN DIRECTED VACUOLE MOVEMENT DURING CELL DIVISION IN SACCHAROMYCES CEREVISIAE

    K L Hill;N L Catlett;L S Weisman

  • Apg13p and Vac8p Are Part of a Complex of Phosphoproteins That Are Required for Cytoplasm to Vacuole Targeting

    Sidney V. Scott;Daniel C. Nice;Johnathan J. Nau;Lois S. Weisman

  • Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice

    Yanling Zhang;Sergey N. Zolov;Clement Y. Chow;Shalom G. Slutsky

  • Vac8p, a Vacuolar Protein with Armadillo Repeats, Functions in both Vacuole Inheritance and Protein Targeting from the Cytoplasm to Vacuole

    Yong Xu Wang;Natalie L. Catlett;Lois S. Weisman

  • In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P

    Sergey N. Zolov;Dave Bridges;Yanling Zhang;Wei Wei Lee

  • Phosphatidylinositol 3,5‐bisphosphate: Low abundance, high significance

    Amber J. McCartney;Yanling Zhang;Lois S. Weisman

  • Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.

    Jonathan D. Gary;Trey K. Sato;Christopher J. Stefan;Cecilia J. Bonangelino

  • Phosphoinositide 5-Phosphatase Fig4p Is Required for both Acute Rise and Subsequent Fall in Stress-Induced Phosphatidylinositol 3,5-Bisphosphate Levels

    Jason E. Duex;Johnathan J. Nau;Emily J. Kauffman;Lois S. Weisman

  • The terminal tail region of a yeast myosin-V mediates its attachment to vacuole membranes and sites of polarized growth

    Natalie L. Catlett;Lois S. Weisman

  • Yeast Vacuole Inheritance and Dynamics

    Lois S. Weisman

  • The Vac14p–Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover

    Jason E. Duex;Fusheng Tang;Lois S. Weisman;Lois S. Weisman

  • Organelles on the move: insights from yeast vacuole inheritance

    Lois S. Weisman

Frequent Co-Authors

Miriam H. Meisler
Miriam H. Meisler University of Michigan–Ann Arbor
William Wickner
William Wickner Dartmouth College
Daniel J. Klionsky
Daniel J. Klionsky University of Michigan–Ann Arbor
Alan R. Saltiel
Alan R. Saltiel University of California, San Diego
Haoxing Xu
Haoxing Xu University of Michigan–Ann Arbor
Scott D. Emr
Scott D. Emr Cornell University
Michael A. Sutton
Michael A. Sutton University of Michigan–Ann Arbor
John Landers
John Landers University of Massachusetts Chan Medical School
Graça Raposo
Graça Raposo Institut Curie
Yusuke Nakamura
Yusuke Nakamura National Institutes of Biomedical Innovation, Health and Nutrition

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