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Keisuke Okita

Keisuke Okita

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
34318
World Ranking
15328
National Ranking
1085

Overview

Keisuke Okita is affiliated with Kyoto University in Japan. Their research work spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with a particular focus on molecular biology and genetics as primary subfields.

Their publications cover topics including:

  • Renal and related cancers
  • Pluripotent Stem Cells Research
  • CRISPR and Genetic Engineering
  • Genetic and Kidney Cyst Diseases
  • Renal cell carcinoma treatment
  • Genomics and Chromatin Dynamics
  • Blood disorders and treatments

Keisuke Okita has published extensively in venues such as:

  • Scientific Reports
  • Nature Communications
  • Stem Cell Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biochemical and Biophysical Research Communications

The following recent papers illustrate the research areas covered:

  • Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect (2023, Nature Communications)
  • A novel ADPKD model using kidney organoids derived from disease-specific human iPSCs (2020, Biochemical and Biophysical Research Communications)
  • Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells (2021, Cell Reports)
  • Identification of candidate PAX2-regulated genes implicated in human kidney development (2021, Scientific Reports)
  • B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors (2023, Nature Communications)

Frequent collaborators include:

  • Kenji Osafune
  • Masahito Yoshihara
  • Shin-Ichi Mae
  • Toshikazu Araoka
  • Akitsu Hotta

Okita's work largely involves the study of pluripotent stem cells, genetic engineering techniques such as CRISPR, and investigations into renal diseases and cancers. Their studies contribute to understanding the molecular and genomic mechanisms underlying kidney development, disease models, and regenerative medicine approaches, such as the use of induced pluripotent stem cells for modeling and treatment.

Best Publications

  • Generation of germline-competent induced pluripotent stem cells

    Keisuke Okita;Tomoko Ichisaka;Shinya Yamanaka

  • Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts

    Masato Nakagawa;Michiyo Koyanagi;Koji Tanabe;Kazutoshi Takahashi

  • Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors

    Keisuke Okita;Masato Nakagawa;Hong Hyenjong;Tomoko Ichisaka

  • A more efficient method to generate integration-free human iPS cells

    Keisuke Okita;Yasuko Matsumura;Yoshiko Sato;Aki Okada

  • Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

    Hyenjong Hong;Kazutoshi Takahashi;Tomoko Ichisaka;Takashi Aoi

  • Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells

    Takashi Aoi;Kojiro Yae;Masato Nakagawa;Tomoko Ichisaka

  • Induction of pluripotent stem cells from fibroblast cultures.

    Kazutoshi Takahashi;Keisuke Okita;Masato Nakagawa;Shinya Yamanaka

  • Variation in the safety of induced pluripotent stem cell lines

    Kyoko Miura;Yohei Okada;Takashi Aoi;Aki Okada

  • Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells

    Yoshinori Yoshida;Kazutoshi Takahashi;Keisuke Okita;Tomoko Ichisaka

  • Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

    Takayuki Kondo;Masashi Asai;Masashi Asai;Kayoko Tsukita;Yumiko Kutoku

  • An Efficient Nonviral Method to Generate Integration-Free Human-Induced Pluripotent Stem Cells from Cord Blood and Peripheral Blood Cells†‡§

    Keisuke Okita;Tatsuya Yamakawa;Yasuko Matsumura;Yoshiko Sato

  • Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model

    Tetsuhiro Kikuchi;Asuka Morizane;Daisuke Doi;Hiroaki Magotani

  • Drug screening for ALS using patient-specific induced pluripotent stem cells.

    Naohiro Egawa;Shiho Kitaoka;Kayoko Tsukita;Motoko Naitoh

  • Directed and Systematic Differentiation of Cardiovascular Cells From Mouse Induced Pluripotent Stem Cells

    Genta Narazaki;Hideki Uosaki;Mizue Teranishi;Keisuke Okita

  • Correction: Corrigendum: Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects

    Osamu Hashizume;Sakiko Ohnishi;Takayuki Mito;Akinori Shimizu

  • Generation of retinal cells from mouse and human induced pluripotent stem cells.

    Yasuhiko Hirami;Fumitaka Osakada;Kazutoshi Takahashi;Keisuke Okita

  • Premature Termination of Reprogramming In Vivo Leads to Cancer Development through Altered Epigenetic Regulation

    Kotaro Ohnishi;Kotaro Ohnishi;Katsunori Semi;Takuya Yamamoto;Masahito Shimizu

  • Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility.

    Huaigeng Xu;Bo Wang;Miyuki Ono;Akihiro Kagita

  • Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells

    Masatoshi Kajiwara;Takashi Aoi;Keisuke Okita;Ryosuke Takahashi

  • Immunogenicity of Induced Pluripotent Stem Cells

    Keisuke Okita;Naoki Nagata;Shinya Yamanaka

Frequent Co-Authors

Shinya Yamanaka
Shinya Yamanaka Kyoto University
Masato Nakagawa
Masato Nakagawa Kyoto University
Kazutoshi Takahashi
Kazutoshi Takahashi New York Stem Cell Foundation
Akira Watanabe
Akira Watanabe Kyoto University
Yasuhiro Yamada
Yasuhiro Yamada University of Tokyo
Takuya Yamamoto
Takuya Yamamoto Kyoto University
Tatsutoshi Nakahata
Tatsutoshi Nakahata Kyoto University
Akitsu Hotta
Akitsu Hotta Kyoto University
Ryosuke Takahashi
Ryosuke Takahashi Kyoto University
Hiroyuki Hioki
Hiroyuki Hioki Juntendo University

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