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Akitsu Hotta

Akitsu Hotta

D-Index & Metrics

Molecular Biology

D-Index
45
Citations
9668
World Ranking
2847
National Ranking
213

Overview

Akitsu Hotta is affiliated with Kyoto University in Japan and has an extensive research portfolio primarily situated within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work notably spans key subfields such as Molecular Biology, Genetics, Oncology, Immunology, and Surgery.

The main topics of Hotta's research include:

  • CRISPR and Genetic Engineering
  • Pluripotent Stem Cells Research
  • CAR-T cell therapy research
  • RNA Interference and Gene Delivery
  • Muscle Physiology and Disorders
  • Virus-based gene therapy research
  • Tissue Engineering and Regenerative Medicine

Hotta has published frequently in several scientific venues, with notable numbers of publications in:

  • Stem Cell Reports (6 publications)
  • Nature Communications (3 publications)
  • Cell Stem Cell (3 publications)
  • Nature Biomedical Engineering (2 publications)
  • Biochemical and Biophysical Research Communications (2 publications)

Their recent papers include the following titles:

  • "Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping," 2020, Nature Communications
  • "Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice," 2021, Nature Communications
  • "Delivery of CRISPR-Cas tools for in vivo genome editing therapy: Trends and challenges," 2022, Journal of Controlled Release
  • "Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells," 2021, Nature Biomedical Engineering
  • "Tissue-Engineered Vascular Grafts with Advanced Mechanical Strength from Human iPSCs," 2020, Cell Stem Cell

Akitsu Hotta collaborates frequently with several researchers, including:

  • Hidetoshi Sakurai
  • Huaigeng Xu
  • Peter Gee
  • Yuya Okuzaki
  • Akihiro Kagita

Best Publications

  • Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines.

    Steven J. Kattman;Alec D. Witty;Alec D. Witty;Mark Gagliardi;Nicole C. Dubois

  • Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9

    Hongmei Lisa Li;Naoko Fujimoto;Noriko Sasakawa;Saya Shirai

  • Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility.

    Huaigeng Xu;Bo Wang;Miyuki Ono;Akihiro Kagita

  • Isolation of human iPS cells using EOS lentiviral vectors to select for pluripotency

    Akitsu Hotta;Aaron Y L Cheung;Natalie Farra;Kausalia Vijayaragavan;Kausalia Vijayaragavan

  • Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping.

    Peter Gee;Peter Gee;Mandy S. Y. Lung;Yuya Okuzaki;Noriko Sasakawa

  • Direct Comparison of Autologous and Allogeneic Transplantation of iPSC-Derived Neural Cells in the Brain of a Nonhuman Primate

    Asuka Morizane;Daisuke Doi;Tetsuhiro Kikuchi;Keisuke Okita

  • Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation

    Aaron Y.L. Cheung;Lindsay M. Horvath;Daria Grafodatskaya;Peter Pasceri

  • Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro

    Akihito Tanaka;Akihito Tanaka;Knut Woltjen;Katsuya Miyake;Akitsu Hotta

  • Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

    Waleed Rahmani;Sepideh Abbasi;Andrew Hagner;Eko Raharjo

  • The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.

    Keiko Imamura;Yuishin Izumi;Akira Watanabe;Kayoko Tsukita

  • Retroviral vector silencing during iPS cell induction: an epigenetic beacon that signals distinct pluripotent states.

    Akitsu Hotta;James Ellis

  • Constitutive heterochromatin reorganization during somatic cell reprogramming

    Eden Fussner;Ugljesa Djuric;Mike Strauss;Akitsu Hotta

  • Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model

    In Young Choi;Ho Tae Lim;Kenneth Estrellas;Jyothi Mula

  • Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells

    Yoji Kojima;Kotaro Sasaki;Shihori Yokobayashi;Yoshitake Sakai

  • Enhancing T Cell Receptor Stability in Rejuvenated iPSC-Derived T Cells Improves Their Use in Cancer Immunotherapy.

    Atsutaka Minagawa;Atsutaka Minagawa;Atsutaka Minagawa;Toshiaki Yoshikawa;Masaki Yasukawa;Akitsu Hotta

  • CRISPR-Cas3 induces broad and unidirectional genome editing in human cells.

    Hiroyuki Morisaka;Kazuto Yoshimi;Yuya Okuzaki;Peter Gee

  • Focal Transplantation of Human iPSC-Derived Glial-Rich Neural Progenitors Improves Lifespan of ALS Mice

    Takayuki Kondo;Misato Funayama;Kayoko Tsukita;Akitsu Hotta

  • From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing

    Akitsu Hotta;Shinya Yamanaka

  • Cell-type-specific genome editing with a microRNA-responsive CRISPR-Cas9 switch.

    Moe Hirosawa;Yoshihiko Fujita;Callum J. C. Parr;Karin Hayashi

  • MECP2 isoform-specific vectors with regulated expression for Rett syndrome gene therapy.

    Mojgan Rastegar;Akitsu Hotta;Peter Pasceri;Maisam Makarem

Frequent Co-Authors

James Ellis
James Ellis University of Toronto
Shinya Yamanaka
Shinya Yamanaka Kyoto University
Takuya Yamamoto
Takuya Yamamoto Kyoto University
Akira Watanabe
Akira Watanabe Kyoto University
Koji Eto
Koji Eto Kyoto University
Keisuke Okita
Keisuke Okita Kyoto University
Yasuhiro Yamada
Yasuhiro Yamada University of Tokyo
Tatsutoshi Nakahata
Tatsutoshi Nakahata Kyoto University
F. Jeffrey Dilworth
F. Jeffrey Dilworth University of Wisconsin–Madison
Takashi Yamamoto
Takashi Yamamoto Hiroshima University

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Related Online Degrees & Career Pathways

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