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Sidney W. Whiteheart

Sidney W. Whiteheart

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
19119
World Ranking
7708
National Ranking
3513

Overview

Sidney W. Whiteheart is affiliated with the University of Kentucky in the United States and has an extensive body of research primarily within the field of Medicine. Their work focuses deeply on Hematology, with additional research spanning Pulmonary and Respiratory Medicine, Immunology, Cardiology and Cardiovascular Medicine, and Molecular Biology.

Their scientific contributions include numerous studies on platelet biology and blood-related disorders. Key topics covered in their research include platelet disorders and treatments, antiplatelet therapy and cardiovascular diseases, blood coagulation and thrombosis mechanisms, aortic aneurysm repair treatments, the complement system in diseases, blood properties and coagulation, and aortic disease and treatment approaches.

Recent publications by Whiteheart include:

  • Platelets Endocytose Viral Particles and Are Activated via TLR (Toll-Like Receptor) Signaling, 2020, Arteriosclerosis Thrombosis and Vascular Biology
  • Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation, 2020, Proceedings of the National Academy of Sciences
  • Calcium Ion Chelation Preserves Platelet Function During Cold Storage, 2020, Arteriosclerosis Thrombosis and Vascular Biology
  • Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin, 2021, Blood
  • Platelet glycogenolysis is important for energy production and function, 2023, Platelets

Whiteheart frequently publishes in a selected range of scientific venues, which include:

  • Arteriosclerosis Thrombosis and Vascular Biology
  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Platelets
  • Research and Practice in Thrombosis and Haemostasis

Their research collaboration network reflects recurring partnerships with several co-authors, including:

  • Smita Joshi
  • Hammodah R. Alfar
  • Kanakanagavalli Shravani Prakhya
  • Joshua Lykins
  • Daniëlle M. Coenen

Whiteheart's scientific focus is aligned with understanding mechanisms of platelet function, vascular biology, and blood coagulation, contributing to both fundamental knowledge and clinical implications in cardiovascular and hematological health.

Best Publications

  • SNAP receptors implicated in vesicle targeting and fusion

    Thomas Söllner;Sidney W. Whiteheart;Michael Brunner;Hediye Erdjument-Bromage

  • A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

    Thomas Söllner;Mark K. Bennett;Sidney W. Whiteheart;Richard H. Scheller

  • AAA+ proteins: have engine, will work.

    Phyllis I. Hanson;Sidney W. Whiteheart

  • N-ethylmaleimide-sensitive fusion protein: a trimeric ATPase whose hydrolysis of ATP is required for membrane fusion.

    S W Whiteheart;K Rossnagel;S A Buhrow;M Brunner

  • Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein.

    Christian U. Lenzen;Diana Steinmann;Sidney W. Whiteheart;William I. Weis

  • TLR Signals Induce Phagosomal MHC-I Delivery from the Endosomal Recycling Compartment to Allow Cross-Presentation

    Priyanka Nair-Gupta;Alessia Baccarini;Navpreet Tung;Fabian Seyffer

  • A multisubunit particle implicated in membrane fusion.

    D W Wilson;S W Whiteheart;M Wiedmann;M Brunner

  • Conserved arginine residues implicated in ATP hydrolysis, nucleotide-sensing, and inter-subunit interactions in AAA and AAA+ ATPases

    Teru Ogura;Sidney W Whiteheart;Anthony J Wilkinson

  • SNAP family of NSF attachment proteins includes a brain-specific isoform

    Sidney W. Whiteheart;Irene C. Griff;Michael Brunner;Douglas O. Clary;Douglas O. Clary

  • Platelet secretion is kinetically heterogeneous in an agonist-responsive manner

    Deepa Jonnalagadda;Leighton T. Izu;Sidney W. Whiteheart

  • VAMP8/endobrevin is overexpressed in hyperreactive human platelets: suggested role for platelet microRNA.

    A. A. Kondkar;Molly Bray;S. M. Leal;S. Nagalla

  • Endobrevin/VAMP-8 is the primary v-SNARE for the platelet release reaction.

    Qiansheng Ren;Holly Kalani Barber;Garland L. Crawford;Zubair A. Karim

  • The SNARE machinery is involved in apical plasma membrane trafficking in MDCK cells.

    Seng Hui Low;Steven J. Chapin;Christian Wimmer;Sidney W. Whiteheart

  • Molecular mechanisms of platelet exocytosis: role of SNAP-23 and syntaxin 2 in dense core granule release

    Dong Chen;Audrey M. Bernstein;Paula P. Lemons;Sidney W. Whiteheart

  • PKCα regulates platelet granule secretion and thrombus formation in mice

    Olga Konopatskaya;Karen Gilio;Matthew T. Harper;Yan Zhao

  • Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway

    Binggang Xiang;Guoying Zhang;Ling Guo;Xiang-An Li

  • SNAP-mediated protein-protein interactions essential for neurotransmitter release

    W. M. Debello;V. O'connor;T. Dresbach;T. Dresbach;S. W. Whiteheart;S. W. Whiteheart

  • Cellular functions of NSF: Not just SNAPs and SNAREs

    Chunxia Zhao;John T. Slevin;Sidney W. Whiteheart

  • Each Domain of the N-Ethylmaleimide-sensitive Fusion Protein Contributes to Its Transport Activity

    Elzbieta E. Nagiec;Audrey Bernstein;Sidney W. Whiteheart

  • Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis

    Qiansheng Ren;Christian Wimmer;Michael C. Chicka;Shaojing Ye

Frequent Co-Authors

John T. Slevin
John T. Slevin University of Kentucky
Brian Storrie
Brian Storrie University of Arkansas for Medical Sciences
Gerald W. Hart
Gerald W. Hart University of Georgia
James E. Rothman
James E. Rothman Yale University
Andrew J. Morris
Andrew J. Morris University of Kentucky
Michael Fried
Michael Fried University of Zurich
Greg A. Gerhardt
Greg A. Gerhardt University of Kentucky
Paul A. Roche
Paul A. Roche National Institutes of Health
Samuel S.-H. Wang
Samuel S.-H. Wang Princeton University
Robin L. Cooper
Robin L. Cooper University of Kentucky

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