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Paul A. Roche

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
12701
World Ranking
13754
National Ranking
5825

Paul A. Roche publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Paul A. Roche sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 154 publications — 29th percentile

29% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Paul A. Roche D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Paul A. Roche sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 57 D-Index — 31st percentile

31% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Paul A. Roche is affiliated with the National Institutes of Health in the United States. Their research primarily spans the field of Immunology and Microbiology, with a specific focus on Immunology. Additional areas of study include Molecular Biology, Cell Biology, Oncology, and Materials Chemistry.

The scientist's work covers a range of topics related to immune function and pathology. These include:

  • Immunotherapy and Immune Responses
  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction
  • Immune Response and Inflammation
  • Cancer Immunotherapy and Biomarkers
  • Glycosylation and Glycoproteins Research
  • Immune cells in cancer

Paul A. Roche has published frequently in several scientific journals. The most common venue is The Journal of Immunology with seven publications. Other venues include UNC Libraries, ACS Applied Materials & Interfaces, Immunity, and Autophagy.

Selected recent papers include:

  • "Biocompatible Fluorescent Nanodiamonds as Multifunctional Optical Probes for Latent Fingerprint Detection" (2020) in ACS Applied Materials & Interfaces
  • "Pleiotropic consequences of metabolic stress for the major histocompatibility complex class II molecule antigen processing and presentation machinery" (2021) in Immunity
  • "Pancreas-specific SNAP23 depletion prevents pancreatitis by attenuating pathological basolateral exocytosis and formation of trypsin-activating autolysosomes" (2020) in Autophagy
  • "Activation of Dendritic Cells Alters the Mechanism of MHC Class II Antigen Presentation to CD4 T Cells" (2020) in The Journal of Immunology
  • "Ubiquitination of MHC Class II by March-I Regulates Dendritic Cell Fitness" (2020) in The Journal of Immunology

Collaborations figure prominently in their research, with frequent coauthors including:

  • Satoshi Ishido
  • Joanna Bandola-Simon
  • Kyungjin Cho
  • Laurence C. Eisenlohr
  • Joanna Marta Bandola-Simon

Paul A. Roche's research contributions focus on the molecular and cellular mechanisms of the immune system, particularly concerning antigen presentation by major histocompatibility complex (MHC) molecules and T-cell mediated immunity. Their multidisciplinary expertise encompasses both fundamental immunology and related applications in cancer and inflammatory diseases.

Best Publications

  • The ins and outs of MHC class II-mediated antigen processing and presentation

    Paul A. Roche;Kazuyuki Furuta

  • Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

    Paul A. Roche;Peter Cresswell

  • Macropinocytosis in phagocytes: regulation of MHC class-II-restricted antigen presentation in dendritic cells.

    Zhenzhen Liu;Paul A. Roche

  • Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain.

    Paul A. Roche;Michael S. Marks;Michael S. Marks;Peter J. Cresswell

  • Identification of a Novel Syntaxin- and Synaptobrevin/VAMP-binding Protein, SNAP-23, Expressed in Non-neuronal Tissues

    Veerasamy Ravichandran;Ashish Chawla;Paul A. Roche

  • Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation.

    Howard A. Anderson;Elizabeth M. Hiltbold;Paul A. Roche

  • Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients.

    Yenan T. Bryceson;Yenan T. Bryceson;Eva Rudd;Chengyun Y. Zheng;Josefine Edner

  • TLR Signals Induce Phagosomal MHC-I Delivery from the Endosomal Recycling Compartment to Allow Cross-Presentation

    Priyanka Nair-Gupta;Alessia Baccarini;Navpreet Tung;Fabian Seyffer

  • T cell-induced secretion of MHC class II–peptide complexes on B cell exosomes

    Aura Muntasell;Adam C Berger;Paul A Roche

  • Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules.

    Paul A. Roche;Peter Cresswell

  • Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization

    Paul A. Roche;Christina L. Teletski;Espen Stang;Oddmund Bakke

  • Suppression of antigen presentation by IL-10.

    Sharad K Mittal;Paul A Roche

  • Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms

    Niti Puri;Paul A. Roche

  • A lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments.

    M S Marks;P A Roche;E van Donselaar;L Woodruff

  • High-affinity binding of an influenza hemagglutinin-derived peptide to purified HLA-DR.

    P A Roche;P Cresswell

  • Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis

    Harald F. Langer;Kyoung-Jin Chung;Kyoung-Jin Chung;Valeria V. Orlova;Eun Young Choi

  • HIV-1 Tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes

    J. D. Weissman;J. A. Brown;T. K. Howcroft;Jae Hwang

  • Internalization and catabolism of radiolabelled antibodies to the MHC class-II invariant chain by B-cell lymphomas.

    Hans J Hansen;Gaik Lin Ong;Habibe Diril;Anita Valdez

  • Trafficking of MHC class II molecules in the late secretory pathway.

    Elizabeth M Hiltbold;Paul A Roche

  • A neuronal role for SNAP-23 in postsynaptic glutamate receptor trafficking

    Young Ho Suh;Akira Terashima;Ronald S Petralia;Robert J Wenthold

Frequent Co-Authors

Salvatore V. Pizzo
Salvatore V. Pizzo Duke University
Katherine W. Roche
Katherine W. Roche National Institutes of Health
Oddmund Bakke
Oddmund Bakke University of Oslo
Peter Cresswell
Peter Cresswell Yale University
Peter Cresswell
Peter Cresswell Yale University
Sidney W. Whiteheart
Sidney W. Whiteheart University of Kentucky
Eric O. Long
Eric O. Long National Institutes of Health
Michael J. Kruhlak
Michael J. Kruhlak National Institutes of Health
Steven L. Gonias
Steven L. Gonias University of California, San Diego
Michael S. Marks
Michael S. Marks Children's Hospital of Philadelphia

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Best Scientists Citing Paul A. Roche

Jacques Neefjes

Jacques Neefjes

Leiden University Medical Center

Publications: 50

Yenan T. Bryceson

Yenan T. Bryceson

Karolinska Institute

Publications: 49

Oddmund Bakke

Oddmund Bakke

University of Oslo

Publications: 41

Lawrence J. Stern

Lawrence J. Stern

University of Massachusetts Chan Medical School

Publications: 38

Graça Raposo

Graça Raposo

Institut Curie

Publications: 34

Michael S. Marks

Michael S. Marks

Children's Hospital of Philadelphia

Publications: 32

David M. Goldenberg

David M. Goldenberg

Immunomedics (United States)

Publications: 32

Peter Cresswell

Peter Cresswell

Yale University

Publications: 30

Ulrich Blank

Ulrich Blank

Université Paris Cité

Publications: 29

Hidde L. Ploegh

Hidde L. Ploegh

Boston Children's Hospital

Publications: 29

Salvatore V. Pizzo

Salvatore V. Pizzo

Duke University

Publications: 29

Jan-Inge Henter

Jan-Inge Henter

Karolinska University Hospital

Publications: 28

Geneviève de Saint Basile

Geneviève de Saint Basile

Necker-Enfants Malades Hospital

Publications: 25

Alessandro Sette

Alessandro Sette

La Jolla Institute For Allergy & Immunology

Publications: 23

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Dominique Charron

Grenoble Alpes University

Publications: 22

Thierry Galli

Thierry Galli

Inserm

Publications: 21

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