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D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
17909
World Ranking
15373
National Ranking
6418

Overview

R. Michael Garavito is affiliated with Michigan State University in the United States and conducts research spanning multiple areas of medicine and biochemistry. Their scholarly work primarily addresses molecular biology, oncology, pediatrics, perinatology and child health, physiology, and pharmacology.

The main topics of their research include:

  • Porphyrin Metabolism and Disorders
  • Neonatal Health and Biochemistry
  • Erythrocyte Function and Pathophysiology
  • Colorectal Cancer Screening and Detection
  • Colorectal Cancer Treatments and Studies
  • Inflammatory mediators and NSAID effects
  • Porphyrin and Phthalocyanine Chemistry

Garavito has authored publications in several venues with a concentration in biochemistry and medical studies. Frequent publication venues include:

  • Biochemistry
  • UNC Libraries

Their recent papers illustrate sustained engagement with biochemical and cancer-related research. Notable publications include:

  • New TSPO Crystal Structures of Mutant and Heme-Bound Forms with Altered Flexibility, Ligand Binding, and Porphyrin Degradation Activity (2023), published in Biochemistry
  • Correction to "New TSPO Crystal Structures of Mutant and Heme-Bound Forms with Altered Flexibility, Ligand Binding, and Porphyrin Degradation Activity" (2023), published in Biochemistry
  • Hematopoietic prostaglandin D synthase (HPGDS): A high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer (2020), published through UNC Libraries

Garavito collaborates frequently with other researchers, contributing jointly to multiple studies. Their frequent co-authors include:

  • Carrie Hiser
  • Fei Li
  • Robert M. Hall
  • Shelagh Ferguson-Miller
  • Jian Liu

The interdisciplinary nature of Garavito's work is reflected in the combination of fields and subfields, integrating biochemical processes with clinical, oncological, and physiological aspects. This includes detailed studies on molecular mechanisms such as TSPO crystal structures and analyses of enzymes influencing colorectal cancer risk.

Their body of work provides insight into complex biochemical pathways and their implications for human health, particularly in areas related to porphyrin metabolism and colorectal cancer research.

Best Publications

  • Cyclooxygenases: Structural, cellular, and molecular biology

    W. L. Smith;D. L. DeWitt;R. M. Garavito

  • Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2

    W L Smith;R M Garavito;D L DeWitt

  • Detergents as Tools in Membrane Biochemistry

    R. Michael Garavito;Shelagh Ferguson-Miller

  • Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products.

    Masayuki Wada;Cynthia J. DeLong;Yu H. Hong;Caroline J. Rieke

  • Gene transfer from bacteria and archaea facilitated evolution of an extremophilic eukaryote

    Gerald Schönknecht;Gerald Schönknecht;Wei Hua Chen;Wei Hua Chen;Chad M. Ternes;Guillaume G. Barbier

  • The Productive Conformation of Arachidonic Acid Bound to Prostaglandin Synthase

    M. G. Malkowski;S. L. Ginell;W. L. Smith;R. M. Garavito

  • Identification of conserved lipid/detergent-binding sites in a high-resolution structure of the membrane protein cytochrome c oxidase

    Ling Qin;Carrie Hiser;Anne Mulichak;R. Michael Garavito

  • The structure of OmpF porin in a tetragonal crystal form

    SW Cowan;RM Garavito;JN Jansonius;JA Jenkins

  • Structure of the UDP-glucosyltransferase GtfB that modifies the heptapeptide aglycone in the biosynthesis of vancomycin group antibiotics.

    Anne M. Mulichak;Heather C. Losey;Christopher T. Walsh;R.Michael Garavito

  • The cyclooxygenase isoforms: structural insights into the conversion of arachidonic acid to prostaglandins.

    R.Michael Garavito;David L. DeWitt

  • Involvement of Arginine 120, Glutamate 524, and Tyrosine 355 in the Binding of Arachidonate and 2-Phenylpropionic Acid Inhibitors to the Cyclooxygenase Active Site of Ovine Prostaglandin Endoperoxide H Synthase-1

    Dipak K. Bhattacharyya;Marc Lecomte;Caroline Jill Rieke;R. Michael Garavito

  • X-ray diffraction analysis of matrix porin, an integral membrane protein from Escherichia coli outer membranes.

    R.M. Garavito;J. Jenkins;J.N. Jansonius;R. Karlsson

  • Structure of the TDP-epi-vancosaminyltransferase GtfA from the chloroeremomycin biosynthetic pathway

    Anne M. Mulichak;Heather C. Losey;Wei Lu;Zdzislaw Wawrzak

  • The structures of prostaglandin endoperoxide H synthases-1 and -2.

    R Michael Garavito;Michael G Malkowski;David L DeWitt

  • The Structure of Mammalian Cyclooxygenases

    R. Michael Garavito;Anne M. Mulichak

  • Strategies for crystallizing membrane proteins.

    R. Michael Garavito;Daniel Picot;Patrick J. Loll

  • Crystal Structure of Vancosaminyltransferase Gtfd from the Vancomycin Biosynthetic Pathway: Interactions with Acceptor and Nucleotide Ligands

    Anne M. Mulichak;Wei Lu;Heather C. Losey;Christopher T. Walsh

  • Comparative Genomics of Two Closely Related Unicellular Thermo-Acidophilic Red Algae, Galdieria sulphuraria and Cyanidioschyzon merolae, Reveals the Molecular Basis of the Metabolic Flexibility of Galdieria sulphuraria and Significant Differences in Carbohydrate Metabolism of Both Algae

    Guillaume Barbier;Christine Oesterhelt;Matthew D. Larson;Robert G. Halgren

  • Prostaglandin Endoperoxide H Synthase-1 THE FUNCTIONS OF CYCLOOXYGENASE ACTIVE SITE RESIDUES IN THE BINDING, POSITIONING, AND OXYGENATION OF ARACHIDONIC ACID

    Elizabeth D. Thuresson;Karen M. Lakkides;Caroline Jill Rieke;Ying Sun

  • Enzymes and Receptors of Prostaglandin Pathways with Arachidonic Acid-derived Versus Eicosapentaenoic

    Masayuki Wada;Cynthia J. DeLong;Yu H. Hong;Caroline J. Rieke

Frequent Co-Authors

Shelagh Ferguson-Miller
Shelagh Ferguson-Miller Michigan State University
William L. Smith
William L. Smith University of Michigan–Ann Arbor
Yi Zheng
Yi Zheng Cincinnati Children's Hospital Medical Center
Christoph Benning
Christoph Benning Michigan State University
Andreas P. M. Weber
Andreas P. M. Weber Heinrich Heine University Düsseldorf
Christopher T. Walsh
Christopher T. Walsh Stanford University
Alvin H. Schmaier
Alvin H. Schmaier University Hospitals of Cleveland
David L. DeWitt
David L. DeWitt Michigan State University
Curtis G. Wilkerson
Curtis G. Wilkerson Michigan State University
Lawrence J. Marnett
Lawrence J. Marnett Vanderbilt University

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