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Isamu Okamoto

Isamu Okamoto

D-Index & Metrics

Medicine

D-Index
93
Citations
41220
World Ranking
10722
National Ranking
305

Overview

Isamu Okamoto is affiliated with Kyushu University in Japan. Their research primarily centers on Medicine, with a focus on subfields including Pulmonary and Respiratory Medicine, Oncology, Epidemiology, Molecular Biology, and Immunology.

Their research topics encompass several aspects of cancer and respiratory conditions. These include:

  • Lung Cancer Treatments and Mutations
  • Lung Cancer Research Studies
  • Cancer Immunotherapy and Biomarkers
  • Lung Cancer Diagnosis and Treatment
  • Colorectal Cancer Treatments and Studies
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Neuroendocrine Tumor Research Advances

Okamoto has contributed extensively to academic journals. Their frequent publication venues are:

  • Annals of Oncology (18 publications)
  • Journal of Thoracic Oncology (14 publications)
  • Lung Cancer (13 publications)
  • Journal of Clinical Oncology (11 publications)
  • Clinical Lung Cancer (7 publications)

Selected recent papers include:

  • Durvalumab, with or without tremelimumab, plus platinum-etoposide versus platinum-etoposide alone in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): updated results from a randomised, controlled, open-label, phase 3 trial (2020), The Lancet Oncology
  • A Randomized, Placebo-Controlled Trial of Pembrolizumab Plus Chemotherapy in Patients With Metastatic Squamous NSCLC: Protocol-Specified Final Analysis of KEYNOTE-407 (2020), Journal of Thoracic Oncology
  • Efficacy and Safety of Rovalpituzumab Tesirine Compared With Topotecan as Second-Line Therapy in DLL3-High SCLC: Results From the Phase 3 TAHOE Study (2021), Journal of Thoracic Oncology
  • Analysis of acquired resistance mechanisms to osimertinib in patients with EGFR-mutated advanced non-small cell lung cancer from the AURA3 trial (2023), Nature Communications
  • Rovalpituzumab Tesirine as a Maintenance Therapy After First-Line Platinum-Based Chemotherapy in Patients With Extensive-Stage-SCLC: Results From the Phase 3 MERU Study (2021), Journal of Thoracic Oncology

Okamoto frequently collaborates with a set of coauthors, including:

  • Nobuyuki Yamamoto (32 collaborations)
  • Kentaro Tanaka (32 collaborations)
  • Shunichi Sugawara (32 collaborations)
  • Kazuhiko Nakagawa (25 collaborations)
  • Yoichi Nakanishi (22 collaborations)

Best Publications

  • Osimertinib in Untreated EGFR-Mutated Advanced Non–Small-Cell Lung Cancer

    Jean-Charles Soria;Yuichiro Ohe;Johan Vansteenkiste;Thanyanan Reungwetwattana

  • Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial

    Tetsuya Mitsudomi;Satoshi Morita;Yasushi Yatabe;Shunichi Negoro

  • Durvalumab plus platinum–etoposide versus platinum–etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial

    Luis Paz-Ares;Mikhail Dvorkin;Yuanbin Chen;Niels Reinmuth

  • Weekly nab-Paclitaxel in Combination With Carboplatin Versus Solvent-Based Paclitaxel Plus Carboplatin as First-Line Therapy in Patients With Advanced Non–Small-Cell Lung Cancer: Final Results of a Phase III Trial

    Mark A. Socinski;Igor Bondarenko;Nina A. Karaseva;Anatoly M. Makhson

  • Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an open-label, randomised, multicentre, phase 2 study.

    Takashi Seto;Terufumi Kato;Makoto Nishio;Koichi Goto

  • Association of PD-L1 overexpression with activating EGFR mutations in surgically resected nonsmall-cell lung cancer

    K. Azuma;K. Ota;A. Kawahara;S. Hattori

  • Activation of ERBB2 Signaling Causes Resistance to the EGFR-Directed Therapeutic Antibody Cetuximab

    Kimio Yonesaka;Kreshnik Zejnullahu;Isamu Okamoto;Taroh Satoh

  • CNS Response to Osimertinib Versus Standard Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients With Untreated EGFR-Mutated Advanced Non–Small-Cell Lung Cancer

    Thanyanan Reungwetwattana;Kazuhiko Nakagawa;Byoung Chul Cho;Manuel Cobo

  • Randomized, Open-Label, Phase III Study Comparing Irinotecan With Paclitaxel in Patients With Advanced Gastric Cancer Without Severe Peritoneal Metastasis After Failure of Prior Combination Chemotherapy Using Fluoropyrimidine Plus Platinum: WJOG 4007 Trial

    Shuichi Hironaka;Shinya Ueda;Hirofumi Yasui;Tomohiro Nishina

  • Induction of PD-L1 Expression by the EML4–ALK Oncoprotein and Downstream Signaling Pathways in Non–Small Cell Lung Cancer

    Keiichi Ota;Koichi Azuma;Akihiko Kawahara;Satoshi Hattori

  • Ramucirumab plus erlotinib in patients with untreated, EGFR-mutated, advanced non-small-cell lung cancer (RELAY): a randomised, double-blind, placebo-controlled, phase 3 trial.

    Kazuhiko Nakagawa;Edward B Garon;Takashi Seto;Makoto Nishio

  • Durvalumab, with or without tremelimumab, plus platinum-etoposide versus platinum-etoposide alone in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): updated results from a randomised, controlled, open-label, phase 3 trial.

    Jonathan W Goldman;Mikhail Dvorkin;Yuanbin Chen;Niels Reinmuth

  • A Randomized, Placebo-Controlled Trial of Pembrolizumab Plus Chemotherapy in Patients With Metastatic Squamous NSCLC: Protocol-Specified Final Analysis of KEYNOTE-407

    Luis Paz-Ares;David Vicente;Ali Tafreshi;Andrew Robinson

  • Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway

    Isamu Okamoto;Isamu Okamoto;Yoshiaki Kawano;Daizo Murakami;Takashi Sasayama

  • Predictive factors for interstitial lung disease, antitumor response, and survival in non-small-cell lung cancer patients treated with gefitinib.

    Masahiko Ando;Isamu Okamoto;Nobuyuki Yamamoto;Koji Takeda

  • CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration.

    Isamu Okamoto;Yoshiaki Kawano;Hiromasa Tsuiki;Ji Ichiro Sasaki

  • Multicentre prospective phase II trial of gefitinib for advanced non-small cell lung cancer with epidermal growth factor receptor mutations: results of the West Japan Thoracic Oncology Group trial (WJTOG0403)

    K Tamura;I Okamoto;T Kashii;S Negoro

  • Combined Survival Analysis of Prospective Clinical Trials of Gefitinib for Non–Small Cell Lung Cancer with EGFR Mutations

    Satoshi Morita;Isamu Okamoto;Kunihiko Kobayashi;Koichi Yamazaki

  • Phase I Study of YM155, a Novel Survivin Suppressant, in Patients with Advanced Solid Tumors

    Taroh Satoh;Isamu Okamoto;Masaki Miyazaki;Ryotaroh Morinaga

  • Randomized Phase III Trial of Platinum-Doublet Chemotherapy Followed by Gefitinib Compared With Continued Platinum-Doublet Chemotherapy in Japanese Patients With Advanced Non–Small-Cell Lung Cancer: Results of a West Japan Thoracic Oncology Group Trial (WJTOG0203)

    Koji Takeda;Toyoaki Hida;Tosiya Sato;Masahiko Ando

Frequent Co-Authors

Kazuhiko Nakagawa
Kazuhiko Nakagawa Kindai University
Kazuto Nishio
Kazuto Nishio Kindai University
Masahiro Fukuoka
Masahiro Fukuoka Kindai University
Satoshi Morita
Satoshi Morita Kyoto University
Tetsuya Mitsudomi
Tetsuya Mitsudomi Kindai University
Yoshinao Oda
Yoshinao Oda Kyushu University
Yuichiro Ohe
Yuichiro Ohe National Cancer Centre
Pasi A. Jänne
Pasi A. Jänne Harvard University
Hiroaki Okamoto
Hiroaki Okamoto Jichi Medical University
Hideyuki Saya
Hideyuki Saya Fujita Health University

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