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Biology and Biochemistry

D-Index
51
Citations
10489
World Ranking
17091
National Ranking
1228

Overview

Tomoki Todo is affiliated with the University of Tokyo in Japan and focuses on research within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work frequently covers subfields such as Genetics, Oncology, Molecular Biology, Epidemiology, and Biotechnology.

The scientist's main research topics include:

  • Virus-based gene therapy research
  • CAR-T cell therapy research
  • Herpesvirus Infections and Treatments
  • Glioma Diagnosis and Treatment
  • Cancer Research and Treatments
  • Protein Degradation and Inhibitors
  • Viral Infectious Diseases and Gene Expression in Insects

Published papers of note include:

  • Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial, 2022, Nature Medicine
  • A phase I/II study of triple-mutated oncolytic herpes virus G47∆ in patients with progressive glioblastoma, 2022, Nature Communications
  • Efficacy of cancer-specific anti-podoplanin CAR-T cells and oncolytic herpes virus G47Δ combination therapy against glioblastoma, 2022, Molecular Therapy - Oncolytics
  • Oncolytic herpes virus G47Δ works synergistically with CTLA-4 inhibition via dynamic intratumoral immune modulation, 2021, Molecular Therapy - Oncolytics
  • Efficacy of a Third-Generation Oncolytic Herpes Virus G47Δ in Advanced Stage Models of Human Gastric Cancer, 2020, Molecular Therapy - Oncolytics

Frequent co-authors in the scientist's work include:

  • Miwako Iwai
  • Atsushi Hirao
  • Yasushi Ino
  • Kazuya Fukasawa
  • Eiichi Hinoi

Research publications have often appeared in the following venues:

  • Molecular Therapy - Oncolytics (9 publications)
  • Cancer Science (3 publications)
  • Nature Medicine (2 publications)
  • Nature Communications (2 publications)
  • Oncology Letters (2 publications)

Best Publications

  • Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial.

    J M Markert;M D Medlock;S D Rabkin;G Y Gillespie

  • Oncolytic virus therapy: A new era of cancer treatment at dawn

    Hiroshi Fukuhara;Yasushi Ino;Tomoki Todo

  • Autocrine TGF-β Signaling Maintains Tumorigenicity of Glioma-Initiating Cells through Sry-Related HMG-Box Factors

    Hiroaki Ikushima;Tomoki Todo;Yasushi Ino;Masamichi Takahashi

  • Oncolytic herpes simplex virus vector with enhanced MHC class I presentation and tumor cell killing.

    Tomoki Todo;Robert L. Martuza;Samuel D. Rabkin;Paul A. Johnson

  • Attenuated, Replication-Competent Herpes Simplex Virus Type 1 Mutant G207: Safety Evaluation of Intracerebral Injection in Nonhuman Primates

    William D. Hunter;Robert L. Martuza;Frank Feigenbaum;Tomoki Todo

  • Systemic antitumor immunity in experimental brain tumor therapy using a multimutated, replication-competent herpes simplex virus.

    Tomoki Todo;Samuel D. Rabkin;Periasamy Sundaresan;Aiguo Wu

  • Treatment of severe intraventricular hemorrhage by intraventricular infusion of urokinase.

    Tomoki Todo;Masaaki Usui;Kintomo Takakura

  • Functional identification of the primary motor area by corticospinal tractography.

    Kyousuke Kamada;Yutaka Sawamura;Fumiya Takeuchi;Hideaki Kawaguchi

  • Combined use of tractography-integrated functional neuronavigation and direct fiber stimulation

    Kyousuke Kamada;Tomoki Todo;Yoshitaka Masutani;Shigeki Aoki

  • Glioma-initiating Cells Retain Their Tumorigenicity through Integration of the Sox Axis and Oct4 Protein

    Hiroaki Ikushima;Tomoki Todo;Yasushi Ino;Masamichi Takahashi

  • Replication-Competent Herpes Simplex Virus Vector G207 and Cisplatin Combination Therapy for Head and Neck Squamous Cell Carcinoma

    Ali Chahlavi;Tomoki Todo;Robert L. Martuza;Samuel D. Rabkin

  • The motor-evoked potential threshold evaluated by tractography and electrical stimulation.

    Kyousuke Kamada;Tomoki Todo;Takahiro Ota;Kenji Ino

  • Triple gene-deleted oncolytic herpes simplex virus vector double-armed with interleukin 18 and soluble B7-1 constructed by bacterial artificial chromosome-mediated system.

    Hiroshi Fukuhara;Yasushi Ino;Toshihiko Kuroda;Robert L. Martuza

  • 5-Hydroxymethylcytosine Plays a Critical Role in Glioblastomagenesis by Recruiting the CHTOP-Methylosome Complex

    Hiroki Takai;Koji Masuda;Tomohiro Sato;Yuriko Sakaguchi

  • Triple combination of oncolytic herpes simplex virus-1 vectors armed with interleukin-12, interleukin-18, or soluble B7-1 results in enhanced antitumor efficacy.

    Yasushi Ino;Yoshinaga Saeki;Hiroshi Fukuhara;Tomoki Todo

  • Oncolytic virus therapy using genetically engineered herpes simplex viruses.

    Tomoki Todo

  • Visualization of the frontotemporal language fibers by tractography combined with functional magnetic resonance imaging and magnetoencephalography.

    Kyousuke Kamada;Tomoki Todo;Yoshitaka Masutani;Shigeki Aoki

  • Effect of prior exposure to herpes simplex virus 1 on viral vector-mediated tumor therapy in immunocompetent mice.

    A Chahlavi;S D Rabkin;T Todo;P Sundaresan

  • Viral shedding and biodistribution of G207, a multimutated, conditionally replicating herpes simplex virus type 1, after intracerebral inoculation in aotus.

    Tomoki Todo;Frank Feigenbaum;Samuel D. Rabkin;Fred Lakeman

  • Vasospasm prevention with postoperative intrathecal thrombolytic therapy: a retrospective comparison of urokinase, tissue plasminogen activator, and cisternal drainage alone.

    Masaaki Usui;Nobuhito Saito;Katsumi Hoya;Tomoki Todo

Frequent Co-Authors

Samuel D. Rabkin
Samuel D. Rabkin Harvard University
Robert L. Martuza
Robert L. Martuza Harvard Medical School
Kohei Miyazono
Kohei Miyazono University of Tokyo
Atsushi Hirao
Atsushi Hirao Kanazawa University
Tetsu Akiyama
Tetsu Akiyama University of Tokyo
Hideo Iba
Hideo Iba Chiba University
Hiroyuki Aburatani
Hiroyuki Aburatani University of Tokyo
Takaaki Kirino
Takaaki Kirino University of Tokyo
Keiji Miyazawa
Keiji Miyazawa University of Yamanashi
Atsushi Natsume
Atsushi Natsume Nagoya University

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