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Biology and Biochemistry

D-Index
75
Citations
19348
World Ranking
5339
National Ranking
2530

Overview

G. Yancey Gillespie is affiliated with the University of Alabama at Birmingham in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with notable contributions in subfields including Molecular Biology, Genetics, Epidemiology, Cancer Research, and Oncology.

Their work addresses several key topics in biomedical research, particularly focused on cancer and gene therapy. These topics include virus-based gene therapy research, glioma diagnosis and treatment, herpesvirus infections and treatments, cancer-related molecular mechanisms research, CAR-T cell therapy research, cancer research and treatments, and clusterin in disease pathology.

Gillespie has contributed to multiple scientific publications in various respected venues. Frequent publication venues include Cancer Research, Scientific Reports, Neuro-Oncology, Nature, and Nature Communications. This list highlights a consistent engagement with journals highly recognized in oncology and molecular biology.

Notable recent papers authored or co-authored by Gillespie include:

  • Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas, 2021, New England Journal of Medicine
  • Glioma stem cells and their roles within the hypoxic tumor microenvironment, 2020, Theranostics
  • Failure of human rhombic lip differentiation underlies medulloblastoma formation, 2022, Nature
  • N-cadherin upregulation mediates adaptive radioresistance in glioblastoma, 2021, Journal of Clinical Investigation
  • The transcriptional landscape of Shh medulloblastoma, 2021, Nature Communications

Collaboration is a significant aspect of Gillespie's research, with frequent co-authors including James M. Markert, Christopher D. Willey, Christian T. Stackhouse, Gregory K. Friedman, and Joshua D. Bernstock. This network suggests active interdisciplinary and multi-institutional research efforts.

Best Publications

  • Intertumoral Heterogeneity within Medulloblastoma Subgroups

    Florence M.G. Cavalli;Marc Remke;Marc Remke;Marc Remke;Ladislav Rampasek;John Peacock

  • Subgroup-specific structural variation across 1,000 medulloblastoma genomes

    Paul A. Northcott;Paul A. Northcott;David J.H. Shih;John Peacock;Livia Garzia

  • Human cytomegalovirus infection and expression in human malignant glioma.

    Charles S Cobbs;Lualhati Harkins;Minu Samanta;G Yancey Gillespie

  • Phase Ib trial of mutant herpes simplex virus G207 inoculated pre-and post-tumor resection for recurrent GBM.

    James M Markert;Peter G Liechty;Wenquan Wang;Shanna Gaston

  • HuR, a RNA Stability Factor, Is Expressed in Malignant Brain Tumors and Binds to Adenine- and Uridine-rich Elements within the 3′ Untranslated Regions of Cytokine and Angiogenic Factor mRNAs

    L. Burt Nabors;G. Yancey Gillespie;Lualhati Harkins;Peter H. King

  • Engineered herpes simplex virus expressing IL-12 in the treatment of experimental murine brain tumors

    Parker Jn;Gillespie Gy;Love Ce;Randall S

  • Inhibition of Cystine Uptake Disrupts the Growth of Primary Brain Tumors

    Wook Joon Chung;Susan A. Lyons;Gina M. Nelson;Hashir Hamza

  • A Phase 1 Trial of Oncolytic HSV-1, G207, Given in Combination With Radiation for Recurrent GBM Demonstrates Safety and Radiographic Responses

    James M Markert;Shantanu N Razdan;Hui-Chien Kuo;Alan Cantor

  • Differential gene expression profiling in human brain tumors.

    James M. Markert;Catherine M. Fuller;G. Yancey Gillespie;James K. Bubien

  • Treatment of intracranial gliomas in immunocompetent mice using herpes simplex viruses that express murine interleukins.

    S. Andreansky;B. He;J. Van Cott;J. McGhee

  • CD133 is a marker of bioenergetic stress in human glioma.

    Corinne E. Griguer;Claudia R. Oliva;Eric Gobin;Pascale Marcorelles

  • Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma.

    R. Chambers;G. Y. Gillespie;L. Soroceanu;S. Andreansky

  • The application of genetically engineered herpes simplex viruses to the treatment of experimental brain tumors

    S S Andreansky;B He;G Y Gillespie;L Soroceanu

  • Loss of Protein Inhibitors of Activated STAT-3 Expression in Glioblastoma Multiforme Tumors: Implications for STAT-3 Activation and Gene Expression

    Emily C. Brantley;L. Burton Nabors;G. Yancey Gillespie;Youn Hee Choi

  • Brain edema in meningiomas is associated with increased vascular endothelial growth factor expression.

    Corey K. Goldman;Suman Bharara;Cheryl A. Palmer;Jiri Vitek

  • Oncolytic HSV-1 G207 Immunovirotherapy for Pediatric High-Grade Gliomas

    Gregory K Friedman;James M Johnston;Asim K Bag;Joshua D Bernstock

  • Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

    Jonathon Torchia;Brian Golbourn;Shengrui Feng;Shengrui Feng;King Ching Ho

  • Glucose metabolism heterogeneity in human and mouse malignant glioma cell lines.

    Corinne E Griguer;Claudia R Oliva;G Yancey Gillespie

  • In vitro and in vivo gene delivery mediated by a synthetic polycationic amino polymer

    Goldman Ck;Soroceanu L;Smith N;Gillespie Gy

  • Cerebral microenvironment influences expression of the vitronectin gene in astrocytic tumors

    C.L. Gladson;J.N. Wilcox;L. Sanders;G.Y. Gillespie

Frequent Co-Authors

Richard J. Whitley
Richard J. Whitley University of Alabama at Birmingham
Catherine M. Fuller
Catherine M. Fuller University of Alabama at Birmingham
Dale J. Benos
Dale J. Benos University of Alabama at Birmingham
Etty N. Benveniste
Etty N. Benveniste University of Alabama at Birmingham
Anita B. Hjelmeland
Anita B. Hjelmeland University of Alabama at Birmingham
Erwin G. Van Meir
Erwin G. Van Meir University of Alabama at Birmingham
Michael D. Taylor
Michael D. Taylor University of Toronto
Peter B. Dirks
Peter B. Dirks University of Toronto
Jennifer A. Chan
Jennifer A. Chan University of Calgary
Eric Bouffet
Eric Bouffet University of Toronto

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