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Atsushi Natsume

Atsushi Natsume

D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
9807
World Ranking
12201
National Ranking
840

Overview

Atsushi Natsume is affiliated with Nagoya University in Japan and has contributed extensively to research in medicine, with a strong focus on genetics, molecular biology, and neurology. Their work spans diverse areas within cancer research and pulmonary and respiratory medicine.

The scientist's research topics cover multiple aspects of neuro-oncology and cancer diagnostics, including:

  • Glioma Diagnosis and Treatment
  • Meningioma and schwannoma management
  • Cancer Genomics and Diagnostics
  • Extracellular vesicles in disease
  • Brain Metastases and Treatment
  • MicroRNA in disease regulation
  • Neuroblastoma Research and Treatments

Among their frequent co-authors are:

  • Toshihiko Wakabayashi
  • Fumiharu Ohka
  • Kosuke Aoki
  • Kazuya Motomura
  • Junya Yamaguchi

Natsume has published predominantly in journals focused on neuro-oncology and brain tumor pathology. Frequent venues include:

  • Neuro-Oncology Advances
  • Neuro-Oncology
  • PubMed
  • World Neurosurgery
  • Brain Tumor Pathology

Key recent papers authored or co-authored by Natsume include:

  • "The first-in-human phase I study of a brain-penetrant mutant IDH1 inhibitor DS-1001 in patients with recurrent or progressive IDH1-mutant gliomas", 2022, Neuro-Oncology
  • "Effect of CRISPR/Cas9-Mediated PD-1-Disrupted Primary Human Third-Generation CAR-T Cells Targeting EGFRvIII on In Vitro Human Glioblastoma Cell Growth", 2020, Cells
  • "Clinical practice guidance for next-generation sequencing in cancer diagnosis and treatment (edition 2.1)", 2020, International Journal of Clinical Oncology
  • "Efficacy of cancer-specific anti-podoplanin CAR-T cells and oncolytic herpes virus G47Δ combination therapy against glioblastoma", 2022, Molecular Therapy - Oncolytics
  • "Ependymoma-like tumor with mesenchymal differentiation harboring C11orf95-NCOA1/2 or -RELA fusion: A hitherto unclassified tumor related to ependymoma", 2021, Brain Pathology

Best Publications

  • Mutational landscape and clonal architecture in grade II and III gliomas

    Hiromichi Suzuki;Kosuke Aoki;Kenichi Chiba;Yusuke Sato

  • Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment

    Keisuke Katsushima;Atsushi Natsume;Fumiharu Ohka;Fumiharu Ohka;Keiko Shinjo

  • Prognostic relevance of genetic alterations in diffuse lower-grade gliomas.

    Kosuke Aoki;Kosuke Aoki;Hideo Nakamura;Hiromichi Suzuki;Hiromichi Suzuki;Keitaro Matsuo

  • Novel somatic and germline mutations in intracranial germ cell tumours

    Linghua Wang;Shigeru Yamaguchi;Matthew D. Burstein;Keita Terashima

  • IFN-beta down-regulates the expression of DNA repair gene MGMT and sensitizes resistant glioma cells to temozolomide.

    Atsushi Natsume;Dai Ishii;Toshihiko Wakabayashi;Takaya Tsuno

  • Current Trends in Targeted Therapies for Glioblastoma Multiforme

    Fumiharu Ohka;Atsushi Natsume;Toshihiko Wakabayashi

  • Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas

    Wentao Gao;Yutaka Kondo;Lanlan Shen;Yasuhiro Shimizu

  • Podoplanin: An emerging cancer biomarker and therapeutic target.

    Harini Krishnan;Julie Rayes;Tomoyuki Miyashita;Genichiro Ishii

  • Intravenously transplanted human neural stem cells migrate to the injured spinal cord in adult mice in an SDF-1- and HGF-dependent manner

    Hiroki Takeuchi;Atsushi Natsume;Toshihiko Wakabayashi;Chihiro Aoshima

  • Efficient delivery of liposome-mediated MGMT-siRNA reinforces the cytotoxity of temozolomide in GBM-initiating cells

    T Kato;A Natsume;H Toda;H Iwamizu

  • The global DNA methylation surrogate LINE-1 methylation is correlated with MGMT promoter methylation and is a better prognostic factor for glioma.

    Fumiharu Ohka;Atsushi Natsume;Kazuya Motomura;Yugo Kishida

  • Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation

    Fumiharu Ohka;Maki Ito;Melissa Ranjit;Takeshi Senga

  • Antitumor effect and cellular immunity activation by murine interferon-beta gene transfer against intracerebral glioma in mouse.

    A Natsume;M Mizuno;Y Ryuke;J Yoshida

  • The DNA demethylating agent 5‐aza‐2′‐deoxycytidine activates NY‐ESO‐1 antigenicity in orthotopic human glioma

    Atsushi Natsume;Toshihiko Wakabayashi;Kunio Tsujimura;Shinji Shimato

  • EGFR mutations in patients with brain metastases from lung cancer: association with the efficacy of gefitinib.

    Shinji Shimato;Tetsuya Mitsudomi;Takayuki Kosaka;Yasushi Yatabe

  • Benefits of interferon-β and temozolomide combination therapy for newly diagnosed primary glioblastoma with the unmethylated MGMT promoter: A multicenter study.

    Kazuya Motomura;Atsushi Natsume;Yugo Kishida;Hiroyuki Higashi

  • Expression of miR-17-92 enhances anti-tumor activity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts

    Masasuke Ohno;Takayuki Ohkuri;Akemi Kosaka;Kuniaki Tanahashi

  • CAR T cells targeting podoplanin reduce orthotopic glioblastomas in mouse brains

    Satoshi Shiina;Masasuke Ohno;Fumiharu Ohka;Shunichiro Kuramitsu

  • Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma

    Atsushi Natsume;Motokazu Ito;Keisuke Katsushima;Fumiharu Ohka

  • Effectiveness of plasma treatment on gastric cancer cells

    Koji Torii;Suguru Yamada;Kae Nakamura;Hiromasa Tanaka

Frequent Co-Authors

Yukinari Kato
Yukinari Kato Tohoku University
Seishi Ogawa
Seishi Ogawa Kyoto University
Atsushi Enomoto
Atsushi Enomoto Nagoya University
Satoru Miyano
Satoru Miyano Tokyo Medical and Dental University
Ho Keung Ng
Ho Keung Ng Chinese University of Hong Kong
Masahide Takahashi
Masahide Takahashi Nagoya University
Mika K. Kaneko
Mika K. Kaneko Tohoku University
Yoshitaka Sekido
Yoshitaka Sekido Nagoya University
Joseph C. Glorioso
Joseph C. Glorioso University of Pittsburgh
Richard A. Gibbs
Richard A. Gibbs Baylor College of Medicine

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