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Kazuhiko Takehara

Kazuhiko Takehara

D-Index & Metrics

Immunology

D-Index
88
Citations
22655
World Ranking
1186
National Ranking
44

Medicine

D-Index
89
Citations
23050
World Ranking
12859
National Ranking
376

Overview

Kazuhiko Takehara is affiliated with Kanazawa University in Japan and focuses their research primarily in the field of Medicine. Their work spans multiple subfields, including Pathology and Forensic Medicine, Immunology, Dermatology, Epidemiology, and Rheumatology.

The scientist's research covers a range of topics, with a particular emphasis on systemic sclerosis and related diseases. Other main topics of their research include mast cells and histamine, inflammatory myopathies and dermatomyositis, dermatologic treatments and research, celiac disease research and management, interstitial lung diseases and idiopathic pulmonary fibrosis, and eosinophilic disorders and syndromes.

Frequent venues publishing their research include:

  • Modern Rheumatology
  • European Journal of Dermatology
  • The Journal of Dermatology
  • Journal of Dermatological Science
  • The Lancet Respiratory Medicine

Takehara has collaborated extensively with several coauthors, including:

  • Takashi Matsushita
  • Yasuhito Hamaguchi
  • Masataka Kuwana
  • Osamu Ishikawa
  • Minoru Hasegawa

Among recent papers associated with Takehara's research are:

  • Tocilizumab in systemic sclerosis: a randomised, double-blind, placebo-controlled, phase 3 trial (2020, The Lancet Respiratory Medicine)
  • Performance evaluation of a commercial line blot assay system for detection of myositis- and systemic sclerosis-related autoantibodies (2020, Clinical Rheumatology)
  • Nintedanib in patients with systemic sclerosis-associated interstitial lung disease: A Japanese population analysis of the SENSCIS trial (2020, Modern Rheumatology)
  • Association of functional (GA)n microsatellite polymorphism in the FLI1 gene with susceptibility to human systemic sclerosis (2020, Lara D. Veeken)
  • GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region (2024, Nature Communications)

Best Publications

  • Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model.

    Toshifumi Mori;Shigeru Kawara;Mikio Shinozaki;Nobukazu Hayashi

  • Connective Tissue Growth Factor Gene Expression in Tissue Sections From Localized Scleroderma, Keloid, and Other Fibrotic Skin Disorders

    Atsuyuki Igarashi;Kiyoko Nashiro;Kanako Kikuchi;Shinichi Sato

  • Tocilizumab in systemic sclerosis: a randomised, double-blind, placebo-controlled, phase 3 trial.

    Dinesh Khanna;Celia J F Lin;Daniel E Furst;Jonathan Goldin

  • Quantitative Genetic Variation in CD19 Expression Correlates with Autoimmunity

    Shinichi Sato;Minoru Hasegawa;Manabu Fujimoto;Thomas F. Tedder

  • Common and distinct clinical features in adult patients with anti-aminoacyl-tRNA synthetase antibodies: heterogeneity within the syndrome.

    Yasuhito Hamaguchi;Manabu Fujimoto;Takashi Matsushita;Kenzo Kaji

  • Smad6 Is a Smad1/5-induced Smad Inhibitor CHARACTERIZATION OF BONE MORPHOGENETIC PROTEIN-RESPONSIVE ELEMENT IN THE MOUSE Smad6 PROMOTER

    Wataru Ishida;Wataru Ishida;Toshiaki Hamamoto;Kiyoshi Kusanagi;Ken Yagi

  • Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: a multicenter cross-sectional study.

    Yasuhito Hamaguchi;Masataka Kuwana;Kana Hoshino;Minoru Hasegawa

  • Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis.

    Shinichi Sato;Minoru Hasegawa;Kazuhiko Takehara

  • Guidelines for management of atopic dermatitis

    Hidehisa Saeki;Masutaka Furue;Fukumi Furukawa;Michihiro Hide

  • Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis.

    Shinichi Sato;Tetsuya Nagaoka;Minoru Hasegawa;Takuya Tamatani

  • Elevated serum BAFF levels in patients with systemic sclerosis: Enhanced BAFF signaling in systemic sclerosis B lymphocytes

    Takashi Matsushita;Minoru Hasegawa;Koichi Yanaba;Masanari Kodera

  • CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse.

    Eriko Saito;Manabu Fujimoto;Minoru Hasegawa;Kazuhiro Komura

  • Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins.

    Manabu Fujimoto;Yasuhito Hamaguchi;Kenzo Kaji;Takashi Matsushita

  • Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancy

    Yuki Ichimura;Takashi Matsushita;Yasuhito Hamaguchi;Kenzo Kaji

  • Elevated stratum corneum hydrolytic activity in Netherton syndrome suggests an inhibitory regulation of desquamation by SPINK5-derived peptides.

    Nahoko Komatsu;Minoru Takata;Norio Otsuki;Rie Ohka

  • Both Th2 and Th1 chemokines (TARC/CCL17, MDC/CCL22, and Mig/CXCL9) are elevated in sera from patients with atopic dermatitis.

    Yuka Shimada;Kazuhiko Takehara;Shinichi Sato

  • Delayed Wound Healing in the Absence of Intercellular Adhesion Molecule-1 or L-Selectin Expression

    Tetsuya Nagaoka;Yuko Kaburagi;Yasuhito Hamaguchi;Minoru Hasegawa

  • B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis.

    Minoru Hasegawa;Yasuhito Hamaguchi;Koichi Yanaba;Jean-David Bouaziz

  • Human tissue kallikrein expression in the stratum corneum and serum of atopic dermatitis patients

    Nahoko Komatsu;Kiyofumi Saijoh;Cynthia Kuk;Amber C. Liu

  • Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity.

    Kayo Arikawa;Noriko Takuwa;Hironori Yamaguchi;Naotoshi Sugimoto

Frequent Co-Authors

Minoru Hasegawa
Minoru Hasegawa University of Fukui
Shinichi Sato
Shinichi Sato University of Tokyo
Manabu Fujimoto
Manabu Fujimoto Osaka University
Hironobu Ihn
Hironobu Ihn Kumamoto University
Koichi Yanaba
Koichi Yanaba Jikei University School of Medicine
Masataka Kuwana
Masataka Kuwana Nippon Medical School
Thomas F. Tedder
Thomas F. Tedder Duke University
Yoshihide Asano
Yoshihide Asano University of Tokyo
Eleftherios P. Diamandis
Eleftherios P. Diamandis Mount Sinai Hospital
Osamu Ishikawa
Osamu Ishikawa Gunma University

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Related Online Degrees & Career Pathways

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