2026 Kazuhiro Kakimi: Immunology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Immunology	50	4253	3928	163	146	267	8813

Overview

Kazuhiro Kakimi is affiliated with Kindai University in Japan and has an extensive publication record centered around immunology, oncology, and cancer immunotherapy. Their work primarily spans the fields of Medicine and Immunology and Microbiology, with significant contributions specifically in Oncology, Immunology, Pulmonary and Respiratory Medicine, Surgery, and Molecular Biology.

The main topics of Kakimi's research focus on areas including Cancer Immunotherapy and Biomarkers, Immunotherapy and Immune Responses, Immune Cell Function and Interaction, CAR-T cell therapy research, Immune cells in cancer, Gastric Cancer Management and Outcomes, and Monoclonal and Polyclonal Antibodies Research.

Selected recent publications illustrate their focus on tumor immunity and immunotherapeutic mechanisms:

Highly immunogenic cancer cells require activation of the WNT pathway for immunological escape (2021, Science Immunology)
Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes (2021, Journal for ImmunoTherapy of Cancer)
Classification of primary liver cancer with immunosuppression mechanisms and correlation with genomic alterations (2020, EBioMedicine)
Immunological Microenvironment Predicts the Survival of the Patients with Hepatocellular Carcinoma Treated with Anti-PD-1 Antibody (2021, Liver Cancer)
Deep immunophenotyping at the single-cell level identifies a combination of anti-IL-17 and checkpoint blockade as an effective treatment in a preclinical model of data-guided personalized immunotherapy (2020, Journal for ImmunoTherapy of Cancer)

Kakimi frequently publishes work in specific academic venues including Cancer Research, Journal for ImmunoTherapy of Cancer, Regular and Young Investigator Award Abstracts, Nature Communications, and Scientific Reports.

Among frequent co-authors collaborating with Kakimi are Koji Nagaoka, Yukari Kobayashi, Hirokazu Matsushita, Yasuyuki Seto, and Jun Nakajima, indicating established research partnerships within the immunotherapy and oncology domains.

Best Publications

Natural Killer T Cell Activation Inhibits Hepatitis B Virus Replication in Vivo

Kazuhiro Kakimi;Luca G. Guidotti;Yasuhiko Koezuka;Francis V. Chisari

838
Citations
Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice

Yasushi Sawanobori;Satoshi Ueha;Makoto Kurachi;Takeshi Shimaoka

461
Citations
Blocking Chemokine Responsive to γ–2/Interferon (IFN)-γ Inducible Protein and Monokine Induced by IFN-γ Activity In Vivo Reduces the Pathogenetic but not the Antiviral Potential of Hepatitis B Virus–specific Cytotoxic T Lymphocytes

Kazuhiro Kakimi;Thomas E. Lane;Stefan Wieland;Valerie C. Asensio

278
Citations
Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients

Koji Kurose;Yoshihiro Ohue;Hisashi Wada;Shinsuke Iida

273
Citations
Interleukin-18 Inhibits Hepatitis B Virus Replication in the Livers of Transgenic Mice

Kiminori Kimura;Kazuhiro Kakimi;Stefan Wieland;Luca G. Guidotti

261
Citations
A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous γδ T cells

Jun Nakajima;Tomohiro Murakawa;Takeshi Fukami;Shigenori Goto

231
Citations
Chemokine receptor CXCR3 facilitates CD8+ T cell differentiation into short-lived effector cells leading to memory degeneration

Makoto Kurachi;Junko Kurachi;Fumiko Suenaga;Tatsuya Tsukui

220
Citations
Zoledronate facilitates large-scale ex vivo expansion of functional γδ T cells from cancer patients for use in adoptive immunotherapy*

M Kondo;K Sakuta;A Noguchi;N Ariyoshi

196
Citations
Adoptive immunotherapy for advanced non-small cell lung cancer using zoledronate-expanded γδTcells: a phase I clinical study.

Miki Sakamoto;Jun Nakajima;Tomohiro Murakawa;Takeshi Fukami

190
Citations
CD40 Activation Rescues Antiviral CD8+ T Cells from PD-1-Mediated Exhaustion

Masanori Isogawa;Josan Chung;Yasuhiro Murata;Kazuhiro Kakimi

188
Citations
The simultaneous blockade of chemokine receptors CCR2, CCR5 and CXCR3 by a non-peptide chemokine receptor antagonist protects mice from dextran sodium sulfate-mediated colitis

Hirotake Tokuyama;Satoshi Ueha;Makoto Kurachi;Kouji Matsushima

185
Citations
Immunogenicity and Tolerogenicity of Hepatitis B Virus Structural and Nonstructural Proteins: Implications for Immunotherapy of Persistent Viral Infections

Kazuhiro Kakimi;Masanori Isogawa;JoSan Chung;Alessandro Sette

185
Citations
Activated Intrahepatic Antigen-Presenting Cells Inhibit Hepatitis B Virus Replication in the Liver of Transgenic Mice

Kiminori Kimura;Kazuhiro Kakimi;Stefan Wieland;Luca G. Guidotti

174
Citations
An Immunogram for the Cancer-Immunity Cycle: Towards Personalized Immunotherapy of Lung Cancer

Takahiro Karasaki;Kazuhiro Nagayama;Hideki Kuwano;Jun-ichi Nitadori

169
Citations
Cutting Edge: Inhibition of Hepatitis B Virus Replication by Activated NK T Cells Does Not Require Inflammatory Cell Recruitment to the Liver

Kazuhiro Kakimi;Thomas E. Lane;Francis V. Chisari;Luca G. Guidotti

168
Citations
Human Transporters Associated with Antigen Processing (Taps) Select Epitope Precursor Peptides for Processing in the Endoplasmic Reticulum and Presentation to T Cells

Grégoire Lauvau;Kazuhiro Kakimi;Gabriele Niedermann;Marina Ostankovitch

133
Citations
Antitumor immunity by magnetic nanoparticle-mediated hyperthermia.

Takeshi Kobayashi;Kazuhiro Kakimi;Eiichi Nakayama;Kowichi Jimbow

126
Citations
Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes.

Giovanni Sitia;Masanori Isogawa;Kazuhiro Kakimi;Stefan F. Wieland

126
Citations
Intraperitoneal injection of in vitro expanded Vγ9Vδ2 T cells together with zoledronate for the treatment of malignant ascites due to gastric cancer

Ikuo Wada;Hirokazu Matsushita;Shuichi Noji;Kazuhiko Mori

124
Citations
Highly immunogenic cancer cells require activation of the WNT pathway for immunological escape.

Yoshiko Takeuchi;Tokiyoshi Tanegashima;Eiichi Sato;Takuma Irie

124
Citations
Dendritic cells for cancer immunotherapy

Kazuhiro Kakimi;Atsushi Kondo;Hirokazu Matsushita

0
Citations

Frequent Co-Authors

Kouji Matsushima Tokyo University of Science

Francis V. Chisari Scripps Research Institute

Tatsuhiko Tsunoda University of Tokyo

Yasuyuki Morishita University of Tokyo

Luca G. Guidotti Vita-Salute San Raffaele University

Hiroyuki Aburatani University of Tokyo

Osamu Ohara Chiba University

Masashi Fukayama University of Tokyo

Hidewaki Nakagawa RIKEN

Hiroyoshi Nishikawa Nagoya University

External Links

Personal website of Kazuhiro Kakimi

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