2026 Luca G. Guidotti: Immunology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Immunology	77	1811	1655	70	66	143	23760
Medicine	77	18374	17263	737	705	145	23767

Overview

Luca G. Guidotti is affiliated with Vita-Salute San Raffaele University in Italy. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a notable focus on Immunology, Infectious Diseases, Epidemiology, Hepatology, and Oncology as subfields of study.

The main topics of Luca G. Guidotti's work include:

Hepatitis B Virus Studies
Hepatitis C Virus Research
Immune Cell Function and Interaction
SARS-CoV-2 and COVID-19 Research
Immunotherapy and Immune Responses
Liver Disease Diagnosis and Treatment
COVID-19 Clinical Research Studies

Among the frequent coauthors contributing to their body of work are:

Matteo Iannacone
Pietro Di Lucia
Elisa Bono
Valeria Fumagalli
Leonardo Giustini

They have frequently published in several scientific venues including:

Journal of Hepatology (6 publications)
bioRxiv (Cold Spring Harbor Laboratory) (5 publications)
Science Immunology (2 publications)
Nature Immunology (2 publications)
Nature reviews. Immunology (1 publication)

Significant recent papers by Luca G. Guidotti include:

Immunobiology and pathogenesis of hepatitis B virus infection, 2021, Nature reviews. Immunology
Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming, 2021, Immunity
Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion, 2022, Science Immunology
COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models, 2021, Molecular Therapy
Serum HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV infection, 2020, The Journal of Experimental Medicine

Best Publications

Viral Clearance Without Destruction of Infected Cells During Acute HBV Infection

Luca G. Guidotti;Rosemary Rochford;Josan Chung;Max Shapiro

1676
Citations
Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes

Luca G Guidotti;Luca G Guidotti;Tetsuya Ishikawa;Monte V Hobbs;Brent Matzke

1420
Citations
Noncytolytic control of viral infections by the innate and adaptive immune response.

Luca G. Guidotti;Francis V. Chisari

1374
Citations
Immunobiology and pathogenesis of viral hepatitis.

Luca G. Guidotti;Francis V. Chisari

968
Citations
High-level hepatitis B virus replication in transgenic mice.

L G Guidotti;B Matzke;H Schaller;F V Chisari

857
Citations
Natural Killer T Cell Activation Inhibits Hepatitis B Virus Replication in Vivo

Kazuhiro Kakimi;Luca G. Guidotti;Yasuhiko Koezuka;Francis V. Chisari

838
Citations
Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis.

K. Ando;T. Moriyama;L. G. Guidotti;S. Wirth

575
Citations
Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice

Luca G. Guidotti;Kazuki Ando;Monte V. Hobbs;Tetsuya Ishikawa

575
Citations
Update of the statements on biology and clinical impact of occult hepatitis B virus infection

Giovanni Raimondo;Stephen Locarnini;Teresa Pollicino;Massimo Levrero

528
Citations
A global scientific strategy to cure hepatitis B

Peter A Revill;Francis V Chisari;Joan M Block;Maura Dandri

495
Citations
Immune Pathogenesis of Hepatocellular Carcinoma

Yasunari Nakamoto;Luca G. Guidotti;Christian V. Kuhlen;Patricia Fowler

461
Citations
Immunobiology and pathogenesis of hepatitis B virus infection.

Matteo Iannacone;Luca G Guidotti

459
Citations
Platelets Mediate Cytotoxic T Lymphocyte-Induced Liver Damage.

Matteo Iannacone;Giovanni Sitia;Masanori Isogawa;Patrizia Marchese

448
Citations
Tumor-Targeted Interferon-α Delivery by Tie2-Expressing Monocytes Inhibits Tumor Growth and Metastasis

Michele De Palma;Roberta Mazzieri;Letterio S. Politi;Ferdinando Pucci

363
Citations
Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus

Matteo Iannacone;E. Ashley Moseman;Elena Tonti;Lidia Bosurgi

360
Citations
TO KILL OR TO CURE : OPTIONS IN HOST DEFENSE AGAINST VIRAL INFECTION

Luca G Guidotti;Francis V Chisari

359
Citations
Relative Sensitivity of Hepatitis B Virus and Other Hepatotropic Viruses to the Antiviral Effects of Cytokines

Heike McClary;Rick Koch;Francis V. Chisari;Luca G. Guidotti

353
Citations
Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B

Giovanni Sitia;Roberto Aiolfi;Pietro Di Lucia;Marta Mainetti

352
Citations
Interleukin-12 inhibits hepatitis B virus replication in transgenic mice.

Victoria J. Cavanaugh;Luca G. Guidotti;Francis V. Chisari

352
Citations
A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen

Margaret T. Chen;Jean Noel Billaud;Matti Sällberg;Luca G. Guidotti

350
Citations
Intrahepatic induction of alpha/beta interferon eliminates viral RNA-containing capsids in hepatitis B virus transgenic mice.

Stefan F. Wieland;Luca G. Guidotti;Francis V. Chisari

324
Citations

Frequent Co-Authors

Francis V. Chisari Scripps Research Institute

Matteo Iannacone IRCCS Ospedale San Raffaele

Zaverio M. Ruggeri Scripps Research Institute

Stefan Wieland University Hospital of Basel

Kazuhiro Kakimi Kindai University

Luigi Naldini Vita-Salute San Raffaele University

Ulrich H. von Andrian Harvard University

Alessandro Sette La Jolla Institute For Allergy & Immunology

Pedro R. Lowenstein University of Michigan–Ann Arbor

Maria G. Castro University of Michigan–Ann Arbor

External Links

Personal website of Luca G. Guidotti

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