Paul T. Schumacker

Overview

Best Publications

• Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing.

  N S Chandel;D S McClintock;C E Feliciano;T M Wood

  2344
  Citations

• Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

  N. S. Chandel;E. Maltepe;E. Goldwasser;C. E. Mathieu

  2317
  Citations

• Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

  Matthew G. Vander Heiden;Navdeep S. Chandel;Edward K. Williamson;Paul T. Schumacker

  1750
  Citations

• Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?

  Simran S. Sabharwal;Paul T. Schumacker

  1744
  Citations

• Reactive oxygen species in cancer cells: Live by the sword, die by the sword

  Paul T. Schumacker

  1681
  Citations

• Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

  Robert D. Guzy;Beatrice Hoyos;Emmanuel Robin;Hong Chen

  1674
  Citations

• Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

  Laura A. Sena;Sha Li;Amit Jairaman;Murali Prakriya

  1395
  Citations

• Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia

  Robert D. Guzy;Paul T. Schumacker

  1170
  Citations

• Reactive Oxygen Species Released from Mitochondria during Brief Hypoxia Induce Preconditioning in Cardiomyocytes

  Terry L. Vanden Hoek;Lance B. Becker;Zuohui Shao;Changqing Li

  1058
  Citations

• Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1

  Jaime N. Guzman;Javier Sanchez-Padilla;David Wokosin;Jyothisri Kondapalli

  950
  Citations

• Unraveling the biological roles of reactive oxygen species.

  Michael P. Murphy;Arne Holmgren;Nils Göran Larsson;Barry Halliwell

  918
  Citations

• Intracellular Signaling by Reactive Oxygen Species during Hypoxia in Cardiomyocytes

  Jacques Duranteau;Navdeep S. Chandel;Andre Kulisz;Zuohui Shao

  793
  Citations

• Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation

  Kyle D. Mansfield;Robert D. Guzy;Yi Pan;Yi Pan;Regina M. Young;Regina M. Young

  736
  Citations

• Role of Oxidants in NF-κB Activation and TNF-α Gene Transcription Induced by Hypoxia and Endotoxin

  Navdeep S. Chandel;Wendy C. Trzyna;David S. McClintock;Paul T. Schumacker

  661
  Citations

• Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange.

  Matthew G.Vander Heiden;Navdeep S Chandel;Paul T Schumacker;Craig B Thompson;Craig B Thompson

  639
  Citations

• Generation of superoxide in cardiomyocytes during ischemia before reperfusion.

  Lance B. Becker;Terry L. Vanden Hoek;Zuo Hui Shao;Chang Qing Li

  572
  Citations

• Significant Levels of Oxidants Are Generated by Isolated Cardiomyocytes During Ischemia Prior to Reperfusion

  Terry L. Vanden Hoek;Changqing Li;Zuohui Shao;Paul T. Schumacker

  569
  Citations

• Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival

  Matthew G. Vander Heiden;Navdeep S. Chandel;Xiao Xian Li;Paul T. Schumacker

  535
  Citations

• Cellular oxygen sensing by mitochondria: old questions, new insight

  Navdeep S. Chandel;Paul T. Schumacker

  517
  Citations

• Hypoxia-inducible factor-1 (HIF-1)

  Paul T. Schumacker

  101
  Citations