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Molecular Biology

D-Index
44
Citations
7950
World Ranking
2922
National Ranking
1394

Overview

Pengbo Zhou is affiliated with Cornell University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with additional contributions to Medicine. The subfields of their work include Molecular Biology, Pulmonary and Respiratory Medicine, Oncology, Immunology, and Health, Toxicology and Mutagenesis.

The scientist's research focuses on several main topics which include:

  • Ubiquitin and proteasome pathways
  • Prostate Cancer Treatment and Research
  • DNA Repair Mechanisms
  • RNA modifications and cancer
  • Interferon and immune responses
  • Toxic Organic Pollutants Impact
  • Effects and risks of endocrine disrupting chemicals

Pengbo Zhou has contributed to several recent scientific papers, among them:

  • Roles of the ubiquitin ligase CUL4B and ADP-ribosyltransferase TiPARP in TCDD-induced nuclear export and proteasomal degradation of the transcription factor AHR, 2021, Journal of Biological Chemistry
  • G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer, 2021, Nature Communications
  • UBR5 targets tumor suppressor CDC73 proteolytically to promote aggressive breast cancer, 2022, Cell Death and Disease
  • Engineering Single Pan-Specific Ubiquibodies for Targeted Degradation of All Forms of Endogenous ERK Protein Kinase, 2021, ACS Synthetic Biology
  • CRL4 Ubiquitin Pathway and DNA Damage Response, 2020, Advances in experimental medicine and biology

Frequent coauthors in their research collaborations include:

  • Chandrani Mukhopadhyay
  • Yan Fan
  • Jin Ben
  • Sayed Ala Moududee
  • Dongxia Ge

The principal publication venues for their work have been:

  • Journal of Biological Chemistry
  • Nature Communications
  • Cell Death and Disease
  • ACS Synthetic Biology
  • Advances in experimental medicine and biology

Best Publications

  • Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate.

    Pengbo Zhou;Carolyn Byrne;Jennifer Jacobs;Elaine Fuchs

  • DCAFs, the Missing Link of the CUL4-DDB1 Ubiquitin Ligase

    Jennifer Lee;Pengbo Zhou

  • The hPLIC Proteins May Provide a Link between the Ubiquitination Machinery and the Proteasome

    Maurits F. Kleijnen;Alan H. Shih;Pengbo Zhou;Sushant Kumar

  • p35, the Neuronal-specific Activator of Cyclin-dependent Kinase 5 (Cdk5) Is Degraded by the Ubiquitin-Proteasome Pathway

    Gentry N. Patrick;Pengbo Zhou;Young T. Kwon;Peter M. Howley

  • Ubiquitination and Degradation of the Substrate Recognition Subunits of SCF Ubiquitin–Protein Ligases

    Pengbo Zhou;Peter M Howley

  • Merlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus

    Wei Li;Liru You;Jonathan Cooper;Jonathan Cooper;Gaia Schiavon

  • Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase.

    Ti Li;Xiujuan Chen;Kenneth C. Garbutt;Pengbo Zhou

  • Merlin/NF2 Loss-Driven Tumorigenesis Linked to CRL4DCAF1-Mediated Inhibition of the Hippo Pathway Kinases Lats1 and 2 in the Nucleus

    Wei Li;Jonathan Cooper;Jonathan Cooper;Lu Zhou;Chenyi Yang

  • Harnessing the Ubiquitination Machinery to Target the Degradation of Specific Cellular Proteins

    Pengbo Zhou;Robert Bogacki;Lisa McReynolds;Peter M. Howley

  • Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover

    Chuandong Geng;Bin He;Limei Xu;Christopher E. Barbieri;Christopher E. Barbieri

  • UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation.

    Xiaoai Chen;Yue Zhang;Leonille Douglas;Pengbo Zhou

  • Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells.

    Yong Cang;Jianxuan Zhang;Sally A. Nicholas;Jayson Bastien

  • SPOP mutation leads to genomic instability in prostate cancer

    Gunther Boysen;Gunther Boysen;Gunther Boysen;Christopher E. Barbieri;Davide Prandi;Mirjam Blattner

  • Isolation of a metal-activated transcription factor gene from Candida glabrata by complementation in Saccharomyces cerevisiae

    Pengbo Zhou;Dennis J. Thiele

  • Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B

    Jeffrey Hannah;Pengbo Zhou

  • A protein knockdown strategy to study the function of β-catenin in tumorigenesis

    Feng Cong;Jianxuan Zhang;William Pao;Pengbo Zhou

  • Determining protein half-lives

    Pengbo Zhou

  • Cullins and cancer.

    Jennifer Lee;Pengbo Zhou

  • Pathogenic Role of the CRL4 Ubiquitin Ligase in Human Disease

    Jennifer Lee;Pengbo Zhou

  • NUP98 dysregulation in myeloid leukemogenesis.

    M. A. S. Moore;K. Y. Chung;M. Plasilova;J. J. Schuringa

Frequent Co-Authors

Francesca Demichelis
Francesca Demichelis University of Trento
Malcolm A.S. Moore
Malcolm A.S. Moore Memorial Sloan Kettering Cancer Center
Andrea Sboner
Andrea Sboner Cornell University
Mark A. Rubin
Mark A. Rubin University of Bern
Dennis J. Thiele
Dennis J. Thiele Sisu Pharma
Johann S. de Bono
Johann S. de Bono Institute of Cancer Research
Peter M. Howley
Peter M. Howley Harvard Medical School
Ning Zheng
Ning Zheng University of Washington
Filippo G. Giancotti
Filippo G. Giancotti Columbia University
Hediye Erdjument-Bromage
Hediye Erdjument-Bromage New York University

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