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Filippo G. Giancotti

Filippo G. Giancotti

D-Index & Metrics

Biology and Biochemistry

D-Index
83
Citations
30585
World Ranking
3445
National Ranking
1735

Overview

Filippo G. Giancotti is affiliated with Columbia University in the United States. The scientist's research primarily centers on the intersection of molecular biology and medicine, with significant contributions to the fields of biochemistry, genetics, and molecular biology. Their body of work spans key subfields such as molecular biology, oncology, cancer research, pulmonary and respiratory medicine, and cell biology.

Their research topics involve multiple aspects of cancer biology, including prostate cancer treatment and research, cancer-related molecular mechanisms, cancer cells and metastasis, Hippo pathway signaling and YAP/TAZ, cell adhesion molecules, chromatin remodeling, and cancer mechanisms and therapy.

Giancotti has been involved in numerous journal publications across diverse high-impact venues. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Cell Reports
  • Molecular Cancer Therapeutics
  • Regular and Young Investigator Award Abstracts

Among the notable recent papers authored or co-authored by Giancotti are:

  • "Metastatic colorectal cancer: mechanisms and emerging therapeutics," 2023, Trends in Pharmacological Sciences
  • "Mesenchymal and stem-like prostate cancer linked to therapy-induced lineage plasticity and metastasis," 2022, Cell Reports
  • "LncRNA Malat1 suppresses pyroptosis and T cell-mediated killing of incipient metastatic cells," 2024, Nature Cancer
  • "Prostate epithelial genes define therapy-relevant prostate cancer molecular subtype," 2021, Prostate Cancer and Prostatic Diseases
  • "Phase 0 Clinical Trial of Everolimus in Patients with Vestibular Schwannoma or Meningioma," 2021, Molecular Cancer Therapeutics

Frequent co-authors contributing to these scientific outputs include:

  • Dhiraj Kumar
  • Sreeharsha Gurrapu
  • Hyunho Han
  • Hong Chen
  • Seong-Yeon Bae

Best Publications

  • Integrin signalling during tumour progression.

    Wenjun Guo;Filippo G. Giancotti

  • Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells

    Filippo G. Giancotti;Erkki Ruoslahtl

  • The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression

    Kishore K Wary;Fabrizio Mainiero;Steven J Isakoff;Eugene E Marcantonio

  • β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

    Valerie M Weaver;Sophie Lelièvre;Johnathon N Lakins;Micah A Chrenek

  • A Requirement for Caveolin-1 and Associated Kinase Fyn in Integrin Signaling and Anchorage-Dependent Cell Growth

    Kishore K Wary;Agnese Mariotti;Chiara Zurzolo;Filippo G Giancotti

  • Mechanisms Governing Metastatic Dormancy and Reactivation

    Filippo G. Giancotti

  • Integrin signaling: specificity and control of cell survival and cell cycle progression

    Filippo G Giancotti

  • β4 Integrin Amplifies ErbB2 Signaling to Promote Mammary Tumorigenesis

    Wenjun Guo;Yuliya Pylayeva;Yuliya Pylayeva;Angela Pepe;Toshiaki Yoshioka

  • Rous sarcoma virus-transformed fibroblasts adhere primarily at discrete protrusions of the ventral membrane called podosomes.

    Guido Tarone;Daniela Cirillo;Filippo G. Giancotti;Paolo M. Comoglio

  • Positional control of cell fate through joint integrin/receptor protein kinase signaling.

    Filippo G Giancotti;Guido Tarone

  • The coupling of α6β4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation

    Fabrizio Mainiero;Chiara Murgia;Chiara Murgia;Kishore K. Wary;Kishore K. Wary;Anna Maria Curatola

  • The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic sites

    Hua Gao;Goutam Chakraborty;Ai Ping Lee-Lim;Qianxing Mo

  • Integrins and tumor cell dissemination.

    E. Ruoslahti;F. G. Giancotti

  • A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1).

    B. E. Vogel;G. Tarone;Filippo G Giancotti;J. Gailit

  • EGF-R signaling through Fyn kinase disrupts the function of integrin α6β4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion

    Agnese Mariotti;Paul A. Kedeshian;Michael Dans;Anna Maria Curatola

  • Merlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus

    Wei Li;Liru You;Jonathan Cooper;Jonathan Cooper;Gaia Schiavon

  • Integrin-specific activation of Rac controls progression through the G1 phase of the cell cycle

    Amel Mettouchi;Sharon Klein;Wenjun Guo;Wenjun Guo;Miguel Lopez-Lago

  • Signal transduction by the α6β4 integrin: Distinct β4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes

    Fabrizio Mainiero;Angela Pepe;Kishore K. Wary;Laura Spinardi

  • Integrin-mediated Activation of Focal Adhesion Kinase Is Required for Signaling to Jun NH2-terminal Kinase and Progression through the G1 Phase of the Cell Cycle

    Maja Oktay;Maja Oktay;Kishore K. Wary;Michael Dans;Raymond B. Birge

  • Beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

    Valerie M. Weaver;Sophie Lelievre;Johnathon N. Lakins;Micah A. Chrenek

Frequent Co-Authors

Paolo M. Comoglio
Paolo M. Comoglio FIRC Institute of Molecular Oncology
Guido Tarone
Guido Tarone University of Turin
Pier Carlo Marchisio
Pier Carlo Marchisio Vita-Salute San Raffaele University
Kutluk Oktay
Kutluk Oktay Yale University
Giorgio Inghirami
Giorgio Inghirami Cornell University
Zev Rosenwaks
Zev Rosenwaks Cornell University
Adriana Heguy
Adriana Heguy New York University
Daniel B. Rifkin
Daniel B. Rifkin New York University
Lorenzo Silengo
Lorenzo Silengo University of Turin
Hediye Erdjument-Bromage
Hediye Erdjument-Bromage New York University

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