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Lorenzo Silengo

Lorenzo Silengo

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
15186
World Ranking
7117
National Ranking
170

Overview

Lorenzo Silengo is affiliated with the University of Turin in Italy and is active in research spanning biochemistry, genetics, molecular biology, and medicine. Their work primarily focuses on molecular biology, surgery, cancer research, hepatology, and cell biology, reflecting an interdisciplinary approach to biomedical sciences.

The scientist's research addresses a range of topics including liver physiology and pathology, organ transplantation techniques and outcomes, pancreatic function and diabetes, extracellular vesicles in disease, cancer-related molecular mechanisms, microRNA in disease regulation, and tissue engineering and regenerative medicine.

Recent publications by Lorenzo Silengo demonstrate involvement in multiple areas of biomedical research. Notable papers include:

  • Extracellular Vesicles as Delivery Vehicles for Non-Coding RNAs: Potential Biomarkers for Chronic Liver Diseases (2024, Biomolecules)
  • Evolving Cell-Based and Cell-Free Clinical Strategies for Treating Severe Human Liver Diseases (2020, Cells)
  • Human liver stem cells express UGT1A1 and improve phenotype of immunocompromised Crigler Najjar syndrome type I mice (2020, Scientific Reports)
  • An intrinsic mechanism of metabolic tuning promotes cardiac resilience to stress (2024, EMBO Molecular Medicine)
  • Emerging Cancer Immunotherapies: Cutting-Edge Advances and Innovations in Development (2024, Medical Sciences)

Lorenzo Silengo has frequently collaborated with several researchers in related fields. Regular co-authors include:

  • Maria Beatriz Herrera Sanchez
  • Fiorella Altruda
  • Sharmila Fagoonee
  • Gabriele Saccu
  • Emanuela Tolosano

The scientist has contributed to publications in a variety of journals that cover different biomedical disciplines. These venues include:

  • Biomolecules
  • Cells
  • EMBO Molecular Medicine
  • Scientific Reports
  • Medical Sciences

Best Publications

  • Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation

    Emilio Hirsch;Vladimir L. Katanaev;Cecilia Garlanda;Ornella Azzolino

  • Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion‐dependent cell survival

    Laura Moro;Mascia Venturino;Chiarella Bozzo;Lorenzo Silengo

  • PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

    Enrico Patrucco;Antonella Notte;Laura Barberis;Giulio Selvetella

  • Integrin-induced Epidermal Growth Factor (EGF) Receptor Activation Requires c-Src and p130Cas and Leads to Phosphorylation of Specific EGF Receptor Tyrosines

    Laura Moro;Laura Dolce;Sara Cabodi;Elena Bergatto

  • Extracellular vesicles as an emerging mechanism of cell-to-cell communication.

    Ciro Tetta;Ezio Ghigo;Lorenzo Silengo;Maria Chiara Deregibus

  • Melusin, a muscle-specific integrin β1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload

    Mara Brancaccio;Luigi Fratta;Antonella Notte;Emilio Hirsch

  • Phosphoinositide 3-Kinase p110β Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development

    Elisa Ciraolo;Manuela Iezzi;Romina Marone;Stefano Marengo

  • Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis.

    Ferdinando Di Cunto;Sara Imarisio;Emilio Hirsch;Vania Broccoli

  • Biosynthetic precursors of 30S and 50S ribosomal particles in Escherichia coli.

    Giorgio. Mangiarotti;David. Apirion;David. Schlessinger;L. Silengo

  • Actin cytoskeleton organization in response to integrin-mediated adhesion.

    Paola Defilippi;Cristina Olivo;Mascia Venturino;Laura Dolce

  • Integrating Cardiac PIP3 and cAMP Signaling through a PKA Anchoring Function of p110γ

    Alessia Perino;Alessandra Ghigo;Enrico Ferrero;Fulvio Morello

  • Hemopexin Therapy Improves Cardiovascular Function by Preventing Heme-Induced Endothelial Toxicity in Mouse Models of Hemolytic Diseases

    Francesca Vinchi;Lucia De Franceschi;Alessandra Ghigo;Tim Townes

  • Ubiad1 Is an Antioxidant Enzyme that Regulates eNOS Activity by CoQ10 Synthesis

    Vera Mugoni;Ruben Postel;Valeria Catanzaro;Elisa De Luca

  • E-cadherin endocytosis regulates the activity of Rap1: a traffic light GTPase at the crossroads between cadherin and integrin function

    Fiorella Balzac;Maria Avolio;Simona Degani;Irina Kaverina

  • Differential distribution and modulation of expression of alpha 1/beta 1 integrin on human endothelial cells.

    P Defilippi;V van Hinsbergh;A Bertolotto;P Rossino

  • The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation

    Deborah Chiabrando;Samuele Giuseppe Marro;Sonia Mercurio;C Giorgi

  • Tumor necrosis factor alpha and interferon gamma modulate the expression of the vitronectin receptor (integrin beta 3) in human endothelial cells.

    P Defilippi;G Truffa;G Stefanuto;F Altruda

  • Protection from angiotensin II–mediated vasculotoxic and hypertensive response in mice lacking PI3Kγ

    Carmine Vecchione;Enrico Patrucco;Gennaro Marino;Laura Barberis

  • Expression of beta 1 integrin complexes on the surface of unfertilized mouse oocyte

    Guido Tarone;Ma Russo;Emilio Hirsch;T. Odorisio

  • p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells.

    Sara Cabodi;Laura Moro;Germano Baj;Monica Smeriglio

Frequent Co-Authors

Fiorella Altruda
Fiorella Altruda University of Turin
Emilio Hirsch
Emilio Hirsch University of Turin
Guido Tarone
Guido Tarone University of Turin
Paola Defilippi
Paola Defilippi University of Turin
Paolo Provero
Paolo Provero University of Turin
Pier Paolo Pandolfi
Pier Paolo Pandolfi Beth Israel Deaconess Medical Center
Silvio Aime
Silvio Aime University of Turin
Matthias P. Wymann
Matthias P. Wymann University of Basel
Alessandro Vercelli
Alessandro Vercelli University of Turin
Filippo G. Giancotti
Filippo G. Giancotti Columbia University

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