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Nanduri R. Prabhakar

Nanduri R. Prabhakar

D-Index & Metrics

Medicine

D-Index
83
Citations
20561
World Ranking
15793
National Ranking
7951

Overview

Nanduri R. Prabhakar is affiliated with the University of Chicago in the United States. Their research spans several interconnected fields, primarily focusing on the biochemical, genetic, and molecular biological aspects of physiology and medicine. The scientist's work encompasses extensive investigations into neuroscience, particularly the neurobiology of respiration and sleep, as well as physiological responses related to hypoxia and obstructive sleep apnea.

Their most recent publications highlight key topics in hypoxia and its physiological consequences. Notable papers include:

  • Hypoxia-inducible factors and obstructive sleep apnea (2020, Journal of Clinical Investigation)
  • Hypoxia-inducible factor-1 mediates pancreatic β-cell dysfunction by intermittent hypoxia (2020, American Journal of Physiology-Cell Physiology)
  • Role of olfactory receptor78 in carotid body-dependent sympathetic activation and hypertension in murine models of chronic intermittent hypoxia (2021, Journal of Neurophysiology)
  • Olfactory receptor 78 participates in carotid body response to a wide range of low O2 levels but not severe hypoxia (2020, Journal of Neurophysiology)
  • A pleiotropic hypoxia-sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans (2022, Science Advances)

Their collaborative network includes frequent coauthors such as Jayasri Nanduri, Yingjie Peng, Xiaoyu Su, Ning Wang, and Benjamin Wang. These collaborations reflect a consistent partnership in advancing the understanding of hypoxia-related mechanisms and their physiological implications.

Frequently published venues in their career include:

  • The FASEB Journal
  • Physiology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Neurophysiology
  • Frontiers in Physiology

Their main fields of study are:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine
  • Neuroscience

The subfields addressed in their research work are:

  • Endocrine and Autonomic Systems
  • Physiology
  • Genetics
  • Molecular Biology
  • Cancer Research

The primary research topics explored include:

  • Neuroscience of respiration and sleep
  • High Altitude and Hypoxia
  • Obstructive Sleep Apnea Research
  • Cancer, Hypoxia, and Metabolism
  • Adipose Tissue and Metabolism
  • Epigenetics and DNA Methylation
  • Eicosanoids and Hypertension Pharmacology

Best Publications

  • Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2

    Nanduri R. Prabhakar;Gregg L. Semenza

  • Peripheral Chemoreceptors: Function and Plasticity of the Carotid Body

    Prem Kumar;Nanduri R. Prabhakar

  • Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: Implications for recurrent apneas

    Ying-Jie Peng;Jeffrey L. Overholt;David Kline;Ganesh K. Kumar

  • Heterozygous HIF-1α deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia

    Ying Jie Peng;Guoxiang Yuan;Deviprasadh Ramakrishnan;Suresh D. Sharma

  • H2S mediates O2 sensing in the carotid body.

    Ying Jie Peng;Jayasri Nanduri;Gayatri Raghuraman;Dangjai Souvannakitti

  • Oxygen sensing in the body.

    S. Lahiri;A. Roy;S.M. Baby;T. Hoshi

  • Induction of HIF‐1α expression by intermittent hypoxia: Involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR

    Guoxiang Yuan;Jayasri Nanduri;Shakil Khan;Gregg L. Semenza

  • Oxygen sensing by the carotid body chemoreceptors

    Nanduri R. Prabhakar

  • Invited Review: Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms

    Nanduri R. Prabhakar

  • Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α

    David D. Kline;Ying Jie Peng;Dominador J. Manalo;Gregg L. Semenza

  • Ca2+/Calmodulin Kinase-dependent Activation of Hypoxia Inducible Factor 1 Transcriptional Activity in Cells Subjected to Intermittent Hypoxia

    Guoxiang Yuan;Jayasri Nanduri;C. Raman Bhasker;Gregg L. Semenza

  • EFFECT OF TWO PARADIGMS OF CHRONIC INTERMITTENT HYPOXIA ON CAROTID BODY SENSORY ACTIVITY

    Ying-Jie Peng;Nanduri R. Prabhakar

  • CARBON MONOXIDE : A ROLE IN CAROTID BODY CHEMORECEPTION

    Nanduri R. Prabhakar;Jay L. Dinerman;Faton H. Agani;Solomon H. Snyder

  • Peripheral chemoreceptors in health and disease

    Nanduri R. Prabhakar;Ying-Jie Peng

  • Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress.

    Ganesh K. Kumar;Vandana Rai;Suresh D. Sharma;Devi Prasadh Ramakrishnan

  • The essential role of Cited2, a negative regulator for HIF-1α, in heart development and neurulation

    Zhan Yin;Jennifer Haynie;Xiaoming Yang;Baoguang Han;Baoguang Han

  • Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia

    Guoxiang Yuan;Shakil A. Khan;Weibo Luo;Jayasri Nanduri

  • O2 sensing at the mammalian carotid body: why multiple O2 sensors and multiple transmitters?

    Nanduri R. Prabhakar

  • NADPH oxidase is required for the Sensory Plasticity of the Carotid body by Chronic Intermittent Hypoxia

    Y. J. Peng;J. Nanduri;G. Yuan;N. Wang

  • NO and CO as second messengers in oxygen sensing in the carotid body.

    Nanduri R Prabhakar

Frequent Co-Authors

Gregg L. Semenza
Gregg L. Semenza Johns Hopkins University School of Medicine
Solomon H. Snyder
Solomon H. Snyder Johns Hopkins University School of Medicine
Hugo Lagercrantz
Hugo Lagercrantz Karolinska Institute
Viswanathan Natarajan
Viswanathan Natarajan University of Illinois at Chicago
Jan-Marino Ramirez
Jan-Marino Ramirez University of Washington
Lucy A. Godley
Lucy A. Godley University of Chicago
Larissa A. Shimoda
Larissa A. Shimoda Johns Hopkins University
Joe G.N. Garcia
Joe G.N. Garcia University of Arizona
Chris Peers
Chris Peers University of Leeds
Ting Wang
Ting Wang Washington University in St. Louis

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