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Akira Hirasawa

Akira Hirasawa

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
17076
World Ranking
7767
National Ranking
523

Overview

Akira Hirasawa is affiliated with Okayama University in Japan and has contributed significantly to research spanning neuroscience, biochemistry, genetics, molecular biology, and medicine. Their work covers a range of topics prominently featuring neuropeptides, neuroinflammation, receptor mechanisms, and metabolic processes.

Hirasawa's research primarily focuses on the following main fields of study:

  • Neuroscience
  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Their work further includes detailed exploration within subfields such as molecular biology, cellular and molecular neuroscience, neurology, physiology, and endocrine and autonomic systems.

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Neurology
  • Physiology
  • Endocrine and Autonomic Systems

Among the main topics Hirasawa has investigated repeatedly are neuropeptides and animal physiology, neuroinflammation and neurodegeneration mechanisms, receptor mechanisms and signaling, peroxisome proliferator-activated receptors, regulation of appetite and obesity, metabolism, diabetes, cancer, and diabetes treatment and management.

  • Neuropeptides and Animal Physiology
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Receptor Mechanisms and Signaling
  • Peroxisome Proliferator-Activated Receptors
  • Regulation of Appetite and Obesity
  • Metabolism, Diabetes, and Cancer
  • Diabetes Treatment and Management

Hirasawa has contributed to various peer-reviewed journals, with multiple publications appearing in certain venues. Notable frequently used publication venues include:

  • GeroScience
  • Research Square (Research Square)
  • Environmental Health Perspectives
  • ACS Chemical Neuroscience
  • Scientific Reports

Selected recent papers by Hirasawa provide insight into the scope and focus of their research:

  • Molecular Mechanism of Apoptosis by Amyloid β-Protein Fibrils Formed on Neuronal Cells (2020) - ACS Chemical Neuroscience
  • Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176 (2020) - Scientific Reports
  • A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD2-microglia-provoked neuroinflammation and neurodegeneration in the mouse hippocampus (2021) - Journal of Neuroinflammation
  • Medium-chain triglycerides inhibit long-chain triglyceride-induced GIP secretion through GPR120-dependent inhibition of CCK (2021) - iScience
  • In vivo emergence of beige-like fat in chickens as physiological adaptation to cold environments (2021) - Amino Acids

The frequent co-authors collaborating with Hirasawa include Keiko Iida, Kensuke Iwasa, Shinji Yamamoto, Kei Maruyama, and Yoshinori Takei, indicating ongoing partnerships in exploring related scientific questions and expanding interdisciplinary work.

  • Keiko Iida
  • Kensuke Iwasa
  • Shinji Yamamoto
  • Kei Maruyama
  • Yoshinori Takei

Best Publications

  • Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.

    Akira Hirasawa;Keiko Tsumaya;Takeo Awaji;Susumu Katsuma

  • Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

    Ikuo Kimura;Daisuke Inoue;Takeshi Maeda;Takafumi Hara

  • Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1

    Susumu Katsuma;Akira Hirasawa;Gozoh Tsujimoto

  • Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

    Atsuhiko Ichimura;Akira Hirasawa;Odile Poulain-Godefroy;Odile Poulain-Godefroy;Amélie Bonnefond;Amélie Bonnefond

  • A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese

    Satoko Uno;Hitoshi Zembutsu;Akira Hirasawa;Atsushi Takahashi

  • Free fatty acids induce cholecystokinin secretion through GPR120.

    Toshiki Tanaka;Susumu Katsuma;Susumu Katsuma;Tetsuya Adachi;Taka-aki Koshimizu

  • The regulation of adipogenesis through GPR120.

    Chizu Gotoh;Yeon Hee Hong;Tomoyo Iga;Daisuke Hishikawa

  • miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer

    Tomohiko Tsuruta;Ken Ichi Kozaki;Atsushi Uesugi;Mayuko Furuta

  • Use of recombinant α1-adrenoceptors to characterize subtype selectivity of drugs for the treatment of prostatic hypertrophy

    Rudolf Foglar;Katsushi Shibata;Kuniko Horie;Akira Hirasawa

  • Cloning, Functional Expression and Tissue Distribution of Human cDNA for the α1C-Adrenergic Receptor

    A. Hirasawa;K. Horie;T. Tanaka;K. Takagaki

  • Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis.

    Atsuhiko Ichimura;Akira Hirasawa;Takafumi Hara;Gozoh Tsujimoto

  • Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1.

    Susumu Katsuma;Noriyuki Hatae;Takeaki Yano;Yoshinao Ruike

  • Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets.

    Akira Hirasawa;Fumiko Saito-Ohara;Jun Inoue;Jun Inoue;Daisuke Aoki

  • Free fatty acid receptors and drug discovery.

    Akira Hirasawa;Takafumi Hara;Susumu Katsuma;Tetsuya Adachi

  • Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy.

    Issei Imoto;Hitoshi Tsuda;Akira Hirasawa;Masahiko Miura

  • Distribution and regulation of protein expression of the free fatty acid receptor GPR120.

    Satoshi Miyauchi;Akira Hirasawa;Tomoyo Iga;Ning Liu

  • Novel selective ligands for free fatty acid receptors GPR120 and GPR40

    Takafumi Hara;Akira Hirasawa;Qi Sun;Keiko Sadakane

  • Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic disorders.

    Takafumi Hara;Akira Hirasawa;Atsuhiko Ichimura;Ikuo Kimura

  • Role of free fatty acid receptors in the regulation of energy metabolism

    Takafumi Hara;Daiji Kashihara;Atsuhiko Ichimura;Ikuo Kimura

  • Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic β cells

    Toshiki Tanaka;Takeaki Yano;Tetsuya Adachi;Taka-aki Koshimizu

Frequent Co-Authors

Gozoh Tsujimoto
Gozoh Tsujimoto Kyoto University
Susumu Katsuma
Susumu Katsuma University of Tokyo
Hiroaki Ohno
Hiroaki Ohno Kyoto University
Nobutaka Fujii
Nobutaka Fujii Kyoto University
Issei Imoto
Issei Imoto University of Tokushima
Shinya Oishi
Shinya Oishi Kyoto University
Johji Inazawa
Johji Inazawa Tokyo Medical and Dental University
Akito Tanoue
Akito Tanoue Kumamoto University
Kazuo Kitaura
Kazuo Kitaura Kyoto University
Hitoshi Tsuda
Hitoshi Tsuda National Defense Medical College

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