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Genetics

D-Index
78
Citations
17994
World Ranking
1722
National Ranking
64

Overview

Issei Imoto is affiliated with the University of Tokushima in Japan and specializes in research at the intersection of biochemistry, genetics, molecular biology, and medicine. Their work primarily focuses on genetics and molecular biology, with subfields including pathology and forensic medicine, cancer research, and oncology.

The scientist's research covers several main topics, including:

  • Cancer Genomics and Diagnostics
  • BRCA gene mutations in cancer
  • Genetic Associations and Epidemiology
  • Genetic factors in colorectal cancer
  • Genomics and Rare Diseases
  • RNA modifications and cancer
  • Genomic variations and chromosomal abnormalities

Issei Imoto has published extensively, with notable recent papers including:

  • Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases, 2020, Nature Genetics
  • Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer, 2023, New England Journal of Medicine
  • Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer, 2020, Nature Communications
  • Functions of Breast Cancer Predisposition Genes: Implications for Clinical Management, 2022, International Journal of Molecular Sciences
  • Six years' accomplishment of the Initiative on Rare and Undiagnosed Diseases: nationwide project in Japan to discover causes, mechanisms, and cures, 2022, Journal of Human Genetics

Their frequent co-authors include Keitaro Matsuo, Hidemi Ito, Yuriko N. Koyanagi, Isao Oze, and Yumiko Kasugai.

Issei Imoto's research appears regularly in several scientific venues, with multiple publications in journals such as:

  • Human Genome Variation
  • Journal of Human Genetics
  • Scientific Reports
  • Genes
  • Cancer Science

Best Publications

  • Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer.

    Ken Ichi Kozaki;Issei Imoto;Seiki Mogi;Ken Omura

  • miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma

    Mayuko Furuta;Ken Ich Kozaki;Shinji Tanaka;Shigeki Arii

  • Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases

    Kazuyoshi Ishigaki;Kazuyoshi Ishigaki;Masato Akiyama;Masahiro Kanai;Masahiro Kanai;Atsushi Takahashi

  • Clinical heterogeneity of α‐synuclein gene duplication in Parkinson's disease

    Kenya Nishioka;Shin Hayashi;Matthew J. Farrer;Andrew B. Singleton

  • Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers

    Shozo Honda;Phillipe Loher;Megumi Shigematsu;Juan P. Palazzo

  • PPM1D is a potential target for 17q gain in neuroblastoma

    Fumiko Saito-Ohara;Issei Imoto;Jun Inoue;Hajime Hosoi

  • The tumor suppressive microRNA miR-218 targets the mTOR component rictor and inhibits AKT phosphorylation in oral cancer

    Atsushi Uesugi;Ken Ichi Kozaki;Tomohiko Tsuruta;Mayuko Furuta

  • miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer

    Tomohiko Tsuruta;Ken Ichi Kozaki;Atsushi Uesugi;Mayuko Furuta

  • Alteration in copy numbers of genes as a mechanism for acquired drug resistance.

    Kohichiroh Yasui;Saori Mihara;Chen Zhao;Hiroyuki Okamoto

  • Identification of cIAP1 as a candidate target gene within an amplicon at 11q22 in esophageal squamous cell carcinomas.

    Issei Imoto;Zeng-Quan Yang;Atiphan Pimkhaokham;Hitoshi Tsuda

  • Identification of a Novel Gene, GASC1, within an Amplicon at 9p23–24 Frequently Detected in Esophageal Cancer Cell Lines

    Zeng-Quan Yang;Issei Imoto;Yoji Fukuda;Atiphan Pimkhaokham

  • YAP is a candidate oncogene for esophageal squamous cell carcinoma

    Tomoki Muramatsu;Issei Imoto;Issei Imoto;Takeshi Matsui;Ken Ichi Kozaki

  • Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance

    Sachiko Nishimoto;Daiju Fukuda;Yasutomi Higashikuni;Kimie Tanaka

  • Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets.

    Akira Hirasawa;Fumiko Saito-Ohara;Jun Inoue;Jun Inoue;Daisuke Aoki

  • Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous-cell carcinoma

    Shuhei Komatsu;Issei Imoto;Hitoshi Tsuda;Hitoshi Tsuda;Ken Ich Kozaki

  • TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas.

    Kohichiroh Yasui;Shigeki Arii;Chen Zhao;Issei Imoto

  • PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma.

    Ken Ichi Kozaki;Issei Imoto;Atiphan Pimkhaokham;Shogo Hasegawa

  • Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: Identification of genetic indicators that predict patient outcome

    Panayiotis Loukopoulos;Tatsuhiro Shibata;Hiroto Katoh;Akiko Kokubu

  • Frequent Silencing of Low Density Lipoprotein Receptor-Related Protein 1B (LRP1B) Expression by Genetic and Epigenetic Mechanisms in Esophageal Squamous Cell Carcinoma

    Itaru Sonoda;Issei Imoto;Jun Inoue;Tatsuhiro Shibata

  • Monitoring the HER2 copy number status in circulating tumor DNA by droplet digital PCR in patients with gastric cancer

    Katsutoshi Shoda;Katsutoshi Shoda;Daisuke Ichikawa;Yuji Fujita;Yuji Fujita;Kiyoshi Masuda

Frequent Co-Authors

Johji Inazawa
Johji Inazawa Tokyo Medical and Dental University
Atsushi Tajima
Atsushi Tajima Kanazawa University
Hitoshi Tsuda
Hitoshi Tsuda National Defense Medical College
Setsuo Hirohashi
Setsuo Hirohashi National Cancer Research Institute, UK
Tatsuhiro Shibata
Tatsuhiro Shibata University of Tokyo
Fumie Hosoda
Fumie Hosoda National Cancer Centre
Yutaka Shimada
Yutaka Shimada Kyoto University
Yae Kanai
Yae Kanai Keio University
Makoto Kinoshita
Makoto Kinoshita University of Tokushima
Akira Hirasawa
Akira Hirasawa Okayama University

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