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Genetics

D-Index
48
Citations
13840
World Ranking
4031
National Ranking
91

Overview

Tiziana Bonaldi is affiliated with the European Institute of Oncology in Italy. Their research activity centers primarily on the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus on Molecular Biology, Cancer Research, and Oncology. The scope of their work spans several specialized areas including Epigenetics and DNA Methylation, Cancer-related gene regulation, and Genomics and Chromatin Dynamics.

Bonaldi's publication record includes contributions in high-impact journals and venues such as bioRxiv (Cold Spring Harbor Laboratory), where they have 13 publications, Methods in Molecular Biology with 5 publications, Science Advances and Cancer Research each with 4 publications, and Clinical Epigenetics counting 3 contributions. These publication venues reflect a strong engagement with both fundamental and applied molecular techniques relevant to cancer biology and epigenetic regulation.

Frequently collaborating with other researchers, their closest co-authors include Roberta Noberini, Alessandro Cuomo, Enrico Massignani, Luciano Nicosia, and Saverio Minucci. These collaborations suggest a networked research approach within molecular oncology and epigenetic studies.

Some of their recent scientific papers are:

  • "Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid-induced differentiation" (2020, Science Advances)
  • "PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin" (2020, Cell Reports)
  • "Advances in enrichment methods for mass spectrometry-based proteomics analysis of post-translational modifications" (2022, Journal of Chromatography A)
  • "Lipid nanoparticles allow efficient and harmless ex vivo gene editing of human hematopoietic cells" (2023, Blood)
  • "Spatial epi-proteomics enabled by histone post-translational modification analysis from low-abundance clinical samples" (2021, Clinical Epigenetics)

Their main research topics revolve around several key themes related to cancer biology and molecular regulation mechanisms, specifically:

  • Epigenetics and DNA Methylation
  • Cancer-related gene regulation
  • Genomics and Chromatin Dynamics
  • Histone Deacetylase Inhibitors Research
  • RNA modifications and cancer
  • Advanced Proteomics Techniques and Applications
  • Peptidase Inhibition and Analysis

Best Publications

  • Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

    Mario F Fraga;Esteban Ballestar;Ana Villar-Garea;Manuel Boix-Chornet

  • Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion

    Tiziana Bonaldi;Fabio Talamo;Paola Scaffidi;Denise Ferrera

  • The High Mobility Group (Hmg) Boxes of the Nuclear Protein Hmg1 Induce Chemotaxis and Cytoskeleton Reorganization in Rat Smooth Muscle Cells

    Bernard Degryse;Tiziana Bonaldi;Paola Scaffidi;Susanne Müller

  • The double life of HMGB1 chromatin protein: architectural factor and extracellular signal

    Susanne Müller;Paola Scaffidi;Bernard Degryse;Tiziana Bonaldi

  • Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9

    Dorothea Greiner;Tiziana Bonaldi;Ragnhild Eskeland;Ernst Roemer;Ernst Roemer

  • Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity.

    Karin J. Ferrari;Andrea Scelfo;SriGanesh Jammula;Alessandro Cuomo

  • PTMs on H3 Variants before Chromatin Assembly Potentiate Their Final Epigenetic State

    Alejandra Loyola;Tiziana Bonaldi;Danièle Roche;Axel Imhof

  • Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases

    Rachel Fellows;Jérémy Denizot;Jérémy Denizot;Claudia Stellato;Alessandro Cuomo

  • Tet Proteins Connect the O-Linked N-acetylglucosamine Transferase Ogt to Chromatin in Embryonic Stem Cells

    Pietro Vella;Andrea Scelfo;SriGanesh Jammula;Fulvio Chiacchiera

  • Iodoacetamide-induced artifact mimics ubiquitination in mass spectrometry.

    Michael L Nielsen;Michiel Vermeulen;Tiziana Bonaldi;Jürgen Cox

  • The DNA chaperone HMGB1 facilitates ACF/CHRAC‐dependent nucleosome sliding

    Tiziana Bonaldi;Gernot Längst;Ralf Strohner;Peter B. Becker

  • The HP1α–CAF1–SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin

    Alejandra Loyola;Alejandra Loyola;Alejandra Loyola;Hideaki Tagami;Tiziana Bonaldi;Danièle Roche

  • The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death

    Chiara Pozzi;Alessandro Cuomo;Ilaria Spadoni;Elena Magni

  • Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.

    Jia Yi Fong;Jia Yi Fong;Luca Pignata;Luca Pignata;Pierre-Alexis Goy;Pierre-Alexis Goy;Kimihito Cojin Kawabata

  • Substantial histone reduction modulates genomewide nucleosomal occupancy and global transcriptional output.

    Barbara Celona;Assaf Weiner;Francesca Di Felice;Francesco M. Mancuso

  • Threshold‐controlled ubiquitination of the EGFR directs receptor fate

    Sara Sigismund;Veronica Algisi;Gilda Nappo;Alexia Conte

  • Mass spectrometry-based identification and characterisation of lysine and arginine methylation in the human proteome

    Michael Bremang;Alessandro Cuomo;Anna Maria Agresta;Magdalena Stugiewicz

  • Proteomics profiling of arginine methylation defines PRMT5 substrate specificity

    Daniele Musiani;Jabez Bok;Enrico Massignani;Liling Wu;Liling Wu

  • The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2.

    Vassilis Aidinis;Tiziana Bonaldi;Monica Beltrame;Sandro Santagata

  • Functional Landscape of PCGF Proteins Reveals Both RING1A/B-Dependent-and RING1A/B-Independent-Specific Activities.

    Andrea Scelfo;Daniel Fernández-Pérez;Simone Tamburri;Marika Zanotti

Frequent Co-Authors

Marco Bianchi
Marco Bianchi Vita-Salute San Raffaele University
Saverio Minucci
Saverio Minucci European Institute of Oncology
Axel Imhof
Axel Imhof Ludwig-Maximilians-Universität München
Diego Pasini
Diego Pasini European Institute of Oncology
Giancarlo Pruneri
Giancarlo Pruneri University of Milan
Pier Paolo Di Fiore
Pier Paolo Di Fiore University of Milan
Iros Barozzi
Iros Barozzi Medical University of Vienna
Matthias Mann
Matthias Mann Max Planck Institute of Biochemistry
Gioacchino Natoli
Gioacchino Natoli European Institute of Oncology
Maria Rescigno
Maria Rescigno Humanitas University

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