World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
87
Citations
34158
World Ranking
2787
National Ranking
1435

Overview

Alex Toker is affiliated with Beth Israel Deaconess Medical Center in the United States. Their research is primarily focused in the fields of Biochemistry, Genetics and Molecular Biology, with significant work in Medicine. Key subfields encompass Molecular Biology, Cancer Research, Oncology, Pulmonary and Respiratory Medicine, and Biochemistry.

The main topics of Alex Toker's research include PI3K/AKT/mTOR signaling in cancer, Epigenetics and DNA Methylation, Cancer, Lipids, and Metabolism, Cancer, Hypoxia, and Metabolism, Fibroblast Growth Factor Research, Metabolomics and Mass Spectrometry Studies, and Biochemical and Molecular Research.

Frequent publication venues for Toker's work are the Journal of Biological Chemistry, bioRxiv (Cold Spring Harbor Laboratory), Cancer Research, Cancer Discovery, and UNC Libraries.

Among the recent papers authored by or involving Alex Toker are:

  • JAK-STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States, 2022, Cancer Research
  • PI3K drives the de novo synthesis of coenzyme A from vitamin B5, 2022, Nature
  • Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy, 2020, Journal of Biological Chemistry
  • The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer, 2020, Cancer Discovery
  • FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance, 2021, Nature Cell Biology

Alex Toker has collaborated frequently with several co-authors including Roger Colbran, George Demartino, Lila M. Gierasch, F. Peter Guengerich, and Ruma Banerjee.

Best Publications

  • AKT/PKB Signaling: Navigating the Network

    Brendan D. Manning;Alex Toker

  • Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

    Thomas F. Franke;David R. Kaplan;Lewis C. Cantley;Alex Toker

  • Signalling through the lipid products of phosphoinositide-3-OH kinase

    Alex Toker;Lewis C. Cantley

  • Sequence analysis of mutations and translocations across breast cancer subtypes

    Shantanu Banerji;Kristian Cibulskis;Claudia Rangel-Escareno;Kristin K. Brown

  • Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

    John H. Hartwig;Gary M. Bokoch;Christopher L. Carpenter;Paul A. Janmey

  • Regulation of protein kinase C ζ by PI 3-kinase and PDK-1

    Margaret M. Chou;Weimin Hou;Joanne Johnson;Lauren K. Graham

  • Activation of Phosphoinositide 3-OH Kinase by the α6β4 Integrin Promotes Carcinoma Invasion

    Leslie M Shaw;Isaac Rabinovitz;Helen H.-F Wang;Alex Toker

  • Akt/Protein Kinase B Is Regulated by Autophosphorylation at the Hypothetical PDK-2 Site

    Alex Toker;Alexandra C. Newton

  • Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

    A Toker;M Meyer;K K Reddy;J R Falck

  • Determination of the Specific Substrate Sequence Motifs of Protein Kinase C Isozymes

    Kiyotaka Nishikawa;Alex Toker;Franz-Josef Johannes;Zhou Songyang

  • Cellular Signaling: Pivoting around PDK-1

    Alex Toker;Alexandra C Newton

  • Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)

    Erica M. Dutil;Alex Toker;Alexandra C. Newton

  • The role of NFAT transcription factors in integrin-mediated carcinoma invasion.

    Sebastien Jauliac;Cristina López-Rodriguez;Cristina López-Rodriguez;Leslie M. Shaw;Lawrence F. Brown

  • Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT.

    Merav Yoeli-Lerner;Gary K. Yiu;Isaac Rabinovitz;Peter Erhardt

  • Signaling through protein kinase C.

    Alex Toker

  • PI3K signaling in cancer: beyond AKT.

    Evan C Lien;Christian C Dibble;Alex Toker

  • Protein kinase D mediates a stress-induced NF-κB activation and survival pathway

    Peter Storz;Alex Toker

  • A rapid method for determining protein kinase phosphorylation specificity.

    Jessica E Hutti;Emily T Jarrell;James D Chang;Derek W Abbott

  • NFAT proteins: emerging roles in cancer progression

    Maria Mancini;Alex Toker

  • Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

    Pengda Liu;Michael Begley;Wojciech Michowski;Hiroyuki Inuzuka

Frequent Co-Authors

Lewis C. Cantley
Lewis C. Cantley Harvard University
John M. Asara
John M. Asara Beth Israel Deaconess Medical Center
Wenyi Wei
Wenyi Wei Beth Israel Deaconess Medical Center
Hiroyuki Inuzuka
Hiroyuki Inuzuka Beth Israel Deaconess Medical Center
Alexandra C. Newton
Alexandra C. Newton University of California, San Diego
John H. Hartwig
John H. Hartwig Brigham and Women's Hospital
John A. Badwey
John A. Badwey Brigham and Women's Hospital
Andrius Kazlauskas
Andrius Kazlauskas University of Illinois at Chicago
Matthew Meyerson
Matthew Meyerson Harvard University
Eric S. Lander
Eric S. Lander Broad Institute

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Alex Toker

Trending Scientists

Recently Published Articles