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Molecular Biology

D-Index
83
Citations
51197
World Ranking
886
National Ranking
467

Research.com Recognitions

  • 2017 - Member of the National Academy of Sciences

Overview

Patrick H. O'Farrell is affiliated with the University of California, San Francisco in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with a substantial body of work in Molecular Biology, Cell Biology, Genetics, Aging, and Cellular and Molecular Neuroscience.

The scientist has contributed significantly to several main topics, including:

  • Genomics and Chromatin Dynamics
  • RNA Research and Splicing
  • Epigenetics and DNA Methylation
  • Mitochondrial Function and Pathology
  • Microtubule and mitosis dynamics
  • DNA Repair Mechanisms
  • Protein Degradation and Inhibitors

Patrick H. O'Farrell's recent notable publications include:

  • "Stepwise modifications of transcriptional hubs link pioneer factor activity to a burst of transcription" (2023) in Nature Communications
  • "Interphase-arrested Drosophila embryos activate zygotic gene expression and initiate mid-blastula transition events at a low nuclear-cytoplasmic ratio" (2020) in PLoS Biology
  • "Coordinating transcription and replication to mitigate their conflicts in early Drosophila embryos" (2022) in Cell Reports
  • "Mitigation of age-dependent accumulation of defective mitochondrial genomes" (2022) in Proceedings of the National Academy of Sciences
  • "Temporal control of late replication and coordination of origin firing by self-stabilizing Rif1-PP1 hubs in Drosophila" (2022) in Proceedings of the National Academy of Sciences

Frequent coauthors of the scientist include:

  • Chun-Yi Cho
  • Robert J. Duronio
  • James P. Kemp
  • Ekaterina Korotkevich
  • Daniel N. Conrad

The scientist's work is regularly published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • Zenodo (CERN European Organization for Nuclear Research)
  • PLoS Biology

Patrick H. O'Farrell is recognized as a member of the National Academy of Sciences since 2017.

Best Publications

  • High resolution two-dimensional electrophoresis of proteins.

    Patrick H. O'Farrell

  • High resolution two-dimensional electrophoresis of basic as well as acidic proteins

    Patricia Z. O'Farrell;Howard M. Goodman;Patrick H. O'Farrell

  • Comparative Genomics of the Eukaryotes

    Gerald M. Rubin;Mark D. Yandell;Jennifer R. Wortman;George L. Gabor

  • Genetic control of cell division patterns in the Drosophila embryo

    Bruce A. Edgar;Patrick H. O'Farrell

  • The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing

    Maria-Carla Saleh;Ronald P. van Rij;Armin Hekele;Amethyst Gillis

  • The sequence specificity of homeodomain-DNA interaction

    Claude Desplan;Jim Theis;Patrick H. O'Farrell

  • The three postblastoderm cell cycles of Drosophila embryogenesis are regulated in G2 by string

    Bruce A. Edgar;Patrick H. O'Farrell

  • The engrailed locus of drosophila: In situ localization of transcripts reveals compartment-specific expression

    Thomas Kornberg;Inga Sidén;Patrick O'Farrell;Michael Simon

  • The roles of Drosophila cyclins A and B in mitotic control

    Christian F. Lehner;Patrick H. O'Farrell

  • Development of Embryonic Pattern in D. melanogaster as Revealed by Accumulation of the Nuclear engrailed Protein

    Stephen DiNardo;Jerry M. Kuner;James Theis;Patrick H. O'Farrell

  • Expression and function of Drosophila cyclin A during embryonic cell cycle progression.

    Christian F. Lehner;Patrick H. O'Farrell

  • The Drosophila developmental gene, engrailed , encodes a sequence-specific DNA binding activity

    Claude Desplan;James Theis;Patrick H. O'Farrell

  • Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis.

    Stephen DiNardo;Elizabeth Sher;Jill Heemskerk-Jongens;Judith A. Kassis

  • Progression of the cell cycle through mitosis leads to abortion of nascent transcripts.

    Antony W. Shermoen;Patrick H. O'Farrell

  • Distinct molecular mechanisms regulate cell cycle timing at successive stages of Drosophila embryogenesis

    Brace A. Edgar;Frank Sprenger;Robert J. Duronio;Pierre Leopold

  • Identification of Drosophila gene products required for phagocytosis of Candida albicans.

    Shannon L Stroschein-Stevenson;Edan Foley;Patrick H O'Farrell;Alexander D Johnson

  • A restriction map of the bacteriophage T4 genome.

    Patrick H. O’Farrell;Elizabeth Kutter;Mikiye Nakanishi

  • Terminal cytokinesis events uncovered after an RNAi screen.

    Arnaud Echard;Gilles R.X. Hickson;Edan Foley;Patrick H. O'Farrell

  • The transcription factor E2F is required for S phase during Drosophila embryogenesis.

    R. J. Duronio;P. H. O'farrell;Jing-Er Xie;A. Brook

  • Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F.

    Robert J Duronio;Patrick H. O'Farrell

Frequent Co-Authors

Robert J. Duronio
Robert J. Duronio University of North Carolina at Chapel Hill
Christian F. Lehner
Christian F. Lehner University of Zurich
Arnaud Echard
Arnaud Echard Université Paris Cité
Claude Desplan
Claude Desplan New York University
Bruce A. Edgar
Bruce A. Edgar Huntsman Cancer Institute
Jean-Paul Vincent
Jean-Paul Vincent The Francis Crick Institute
Yuh Nung Jan
Yuh Nung Jan University of California, San Francisco
Lily Yeh Jan
Lily Yeh Jan University of California, San Francisco
Matthew P. Scott
Matthew P. Scott Stanford University
Gerald M. Rubin
Gerald M. Rubin Howard Hughes Medical Institute

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