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Gunnar Hedlund

Gunnar Hedlund

D-Index & Metrics

Biology and Biochemistry

D-Index
47
Citations
6661
World Ranking
18780
National Ranking
295

Overview

Gunnar Hedlund is affiliated with Lund University in Sweden. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with significant focus on subfields including Oncology, Immunology, Pharmacology, and Genetics.

The main topics covered in their work include Cancer Immunotherapy and Biomarkers, Immunotherapy and Immune Responses, Immune cells in cancer, Pharmacological Effects of Natural Compounds, Inflammatory Bowel Disease, and Cytokine Signaling Pathways and Interactions.

Recent publications authored or co-authored by Hedlund include:

  • "Tumor-targeted superantigens produce curative tumor immunity with induction of memory and demonstrated antigen spreading," 2023, Journal of Translational Medicine
  • "P049 A new preclinical rationale for first-line therapy of ulcerative colitis," 2020, Journal of Crohn's and Colitis

Frequent co-authors in Hedlund's research collaborations are:

  • Meir Azulay
  • Michal Shahar
  • Eitan Shany
  • Eti Elbaz
  • Sveta Lifshits

Publications have appeared in venues such as the Journal of Translational Medicine and the Journal of Crohn's and Colitis.

Best Publications

  • Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-β in Lewis rats

    Jian-She Yang;Ling-Yun Xu;Bao-Guo Xiao;Bao-Guo Xiao;Gunnar Hedlund

  • Dendritic cells and macrophages are the first and major producers of TNF-alpha in pancreatic islets in the nonobese diabetic mouse.

    Eva Dahlén;Kim Dawe;Lennart Ohlsson;Gunnar Hedlund

  • The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitis.

    Charlott Brunmark;Anna Runström;Lennart Ohlsson;Birgitta Sparre

  • The resolution of syringohydromyelia without hindbrain herniation after posterior fossa decompression

    B J Iskandar;G L Hedlund;P A Grabb;W J Oakes

  • Synthesis and Biological Evaluation of New 1,2-Dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for Treatment of Autoimmune Disorders: Structure−Activity Relationship

    Stig Jönsson;Gunnar Andersson;Tomas Fex;Tomas Fristedt

  • T Cell Activation Pathways: B7, LFA-3, and ICAM-1 Shape Unique T Cell Profiles

    Anette Gjorloff Wingren;Eduardo Parra;Mikael Varga;Terje Kalland

  • Production of TNF-alpha and TNF-beta by staphylococcal enterotoxin A activated human T cells.

    H Fischer;M Dohlsten;U Andersson;G Hedlund

  • Monoclonal antibody-superantigen fusion proteins: tumor-specific agents for T-cell-based tumor therapy

    M Dohlsten;L Abrahmsén;P Björk;P A Lando

  • In vivo anergized CD4+ T cells express perturbed AP-1 and NF-kappa B transcription factors.

    Anette Sundstedt;Mikael Sigvardsson;Tomas Leanderson;Gunnar Hedlund

  • Monoclonal antibody-targeted superantigens: a different class of anti-tumor agents.

    Mikael Dohlsten;Gunnar Hedlund;Eva Akerblom;Peter A. Lando

  • Low CD86 Expression in the Nonobese Diabetic Mouse Results in the Impairment of Both T Cell Activation and CTLA-4 Up-Regulation

    Eva Dahlén;Gunnar Hedlund;Kim Dawe

  • Air enema for diagnosis and reduction of intussusception: clinical experience and pressure correlates.

    W E Shiels;C K Maves;G L Hedlund;D R Kirks

  • Suppression of experimental autoimmune neuritis by ABR-215062 is associated with altered Th1/Th2 balance and inhibited migration of inflammatory cells into the peripheral nerve tissue

    L.-P. Zou;N. Abbas;I. Volkmann;I. Nennesmo

  • Two subsets of human CD4+ T helper cells differing in kinetics and capacities to produce interleukin 2 and interferon-gamma can be defined by the Leu-18 and UCHL1 monoclonal antibodies.

    Mikael Dohlsten;Gunnar Hedlund;Hans-Olov Sjögren;Roland Carlsson

  • Phase I Dose Escalation, Pharmacokinetic and Pharmacodynamic Study of Naptumomab Estafenatox Alone in Patients With Advanced Cancer and With Docetaxel in Patients With Advanced Non–Small-Cell Lung Cancer

    Hossein Borghaei;Katherine Alpaugh;Gunnar Hedlund;Göran Forsberg

  • Aggressive manifestations of inflammatory pulmonary pseudotumor in children.

    G. L. Hedlund;Joseph F. Navoy;Carlos A. Galliani;W. H. Johnson

  • Stimulation of human naive and memory T helper cells with bacterial superantigen. Naive CD4+45RA+ T cells require a costimulatory signal mediated through the LFA-1/ICAM-1 pathway.

    H Fischer;A Gjörloff;G Hedlund;H Hedman

  • Analysis of the murine lymphokine-activated killer (LAK) cell phenomenon: dissection of effectors and progenitors into NK- and T-like cells.

    T Kalland;H Belfrage;P Bhiladvala;G Hedlund

  • Linomide, a novel immunomodulator that prevents death in four models of septic shock.

    José Angel Gonzalo;Ana González-García;Terje Kalland;Gunnar Hedlund

  • The role of B7-1 and LFA-3 in costimulation of CD8+ T cells.

    E Parra;A G Wingren;G Hedlund;T Kalland

Frequent Co-Authors

Mikael Dohlsten
Mikael Dohlsten Lund University
Henrik Thorlacius
Henrik Thorlacius Lund University
Tomas Leanderson
Tomas Leanderson Lund University
Bao-Guo Xiao
Bao-Guo Xiao Fudan University
Hans Link
Hans Link Karolinska Institute
Jie Zhu
Jie Zhu Jilin University
Robert E. Hawkins
Robert E. Hawkins University of Manchester
David M. Sansom
David M. Sansom University College London
Qing Liu
Qing Liu Chongqing University
John Trowsdale
John Trowsdale University of Cambridge

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