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Microbiology

D-Index
55
Citations
17751
World Ranking
3765
National Ranking
336

Overview

David M. Sansom is affiliated with University College London in the United Kingdom. Their research primarily focuses on immunology, with significant contributions to the fields of medicine and microbiology. Their work covers a range of topics including T-cell and B-cell immunology, immune cell function and interaction, cancer immunotherapy and biomarkers, immunodeficiency and autoimmune disorders, and genomics related to rare diseases.

Their frequent publication venues include Immunology, Frontiers in Immunology, bioRxiv (Cold Spring Harbor Laboratory), Nature, and Cell Reports.

Key recent publications by David M. Sansom include:

  • Whole-genome sequencing of a sporadic primary immunodeficiency cohort, 2020, Nature
  • Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation, 2022, Nature Immunology
  • CD86 Is a Selective CD28 Ligand Supporting FoxP3+ Regulatory T Cell Homeostasis in the Presence of High Levels of CTLA-4, 2020, Frontiers in Immunology
  • CD80 on Human T Cells Is Associated With FoxP3 Expression and Supports Treg Homeostasis, 2021, Frontiers in Immunology
  • Both intratumoral regulatory T cell depletion and CTLA-4 antagonism are required for maximum efficacy of anti-CTLA-4 antibodies, 2023, Proceedings of the National Academy of Sciences

Frequent co-authors who have collaborated with Sansom include Alan Kennedy, Erin Waters, Cayman Williams, Claudia Hinze, and Neil Halliday.

Their research spans multiple areas within immunology and related biomedical sciences, emphasizing cellular immune regulation mechanisms and cancer immunotherapy strategies. The studies published by Sansom explore immune checkpoint proteins such as CTLA-4, CD80, and CD86 and their roles in regulatory T cell homeostasis and immune modulation.

Best Publications

  • Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

    Omar S. Qureshi;Yong Zheng;Kyoko Nakamura;Kesley Attridge

  • CTLA-4: a moving target in immunotherapy

    Behzad Rowshanravan;Neil Halliday;David M. Sansom

  • Normal human pregnancy is associated with an elevation in the immune suppressive CD25+ CD4+ regulatory T-cell subset.

    David A Somerset;Yong Zheng;Mark D Kilby;David M Sansom

  • The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses

    Lucy S. K. Walker;David M. Sansom

  • 1,25-Dihydroxyvitamin D3 and IL-2 Combine to Inhibit T Cell Production of Inflammatory Cytokines and Promote Development of Regulatory T Cells Expressing CTLA-4 and FoxP3

    Louisa E. Jeffery;Fiona Burke;Manuela Mura;Yong Zheng

  • Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.

    Desireé Schubert;Desireé Schubert;Claudia Bode;Rupert Kenefeck;Tie Zheng Hou

  • Extra-renal 25-hydroxyvitamin D3-1α-hydroxylase in human health and disease

    Martin Hewison;Fiona Burke;Katie N. Evans;David A. Lammas

  • Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects

    Charlotte Schwab;Annemarie Gabrysch;Peter Olbrich;Virginia Patiño

  • CD28, CTLA-4 and their ligands: who does what and to whom?

    D M Sansom

  • Confusing signals: Recent progress in CTLA-4 biology

    Lucy S.K. Walker;David M. Sansom

  • The role of CD28 and cytotoxic T‐lymphocyte antigen‐4 (CTLA‐4) in regulatory T‐cell biology

    David M. Sansom;Lucy S. K. Walker

  • Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)

    Rachel C A Dancer;Dhruv Parekh;Sian Lax;Vijay D'Souza

  • What's the difference between CD80 and CD86?

    David M. Sansom;Claire N. Manzotti;Yong Zheng

  • CTLA4 gene polymorphism and autoimmunity

    Stephen C. L. Gough;Lucy S. K. Walker;David M. Sansom

  • CD86 and CD80 differentially modulate the suppressive function of human regulatory T cells

    Yong Zheng;Claire N. Manzotti;Michael Liu;Fiona Burke

  • Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses.

    Louisa E. Jeffery;Alice M. Wood;Omar S. Qureshi;Tie Zheng Hou

  • Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation

    Unknown

  • Whole-genome sequencing of a sporadic primary immunodeficiency cohort

    Thaventhiran Jed.;H Lango Allen;O S Burren;W Rae

  • Low-level Hypermutation in T Cell–independent Germinal Centers Compared with High Mutation Rates Associated with T Cell–dependent Germinal Centers

    Kai-Michael Toellner;William E. Jenkinson;Dale R. Taylor;Mahmood Khan

  • CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement

    Chun Jing Wang;Frank Heuts;Vitalijs Ovcinnikovs;Lukasz Wardzinski

  • Inhibition of human T cell proliferation by CTLA-4 utilizes CD80 and requires CD25+ regulatory T cells.

    Claire N. Manzotti;Helen Tipping;Laura C. A. Perry;Karen I. Mead

  • Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity.

    Emily M. Schmidt;Chun Jing Wang;Gemma A. Ryan;Louise E. Clough

Frequent Co-Authors

Lucy S. K. Walker
Lucy S. K. Walker University College London
Siobhan O. Burns
Siobhan O. Burns University College London
Stephen G. Ward
Stephen G. Ward University of Bath
Kimberly Gilmour
Kimberly Gilmour Great Ormond Street Hospital
Adrian J. Thrasher
Adrian J. Thrasher University College London
David Ellinghaus
David Ellinghaus Kiel University
Jonathan Stephens
Jonathan Stephens University of Cambridge
Austen Worth
Austen Worth Great Ormond Street Hospital
John Westwick
John Westwick Novartis (Switzerland)
Graham Pawelec
Graham Pawelec University of Tübingen

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