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Helena Erlandsson Harris

Helena Erlandsson Harris

D-Index & Metrics

Biology and Biochemistry

D-Index
46
Citations
12833
World Ranking
18836
National Ranking
297

Overview

Helena Erlandsson Harris is affiliated with the Karolinska Institute in Sweden and has produced a significant body of research primarily within the field of Medicine. Their work encompasses several subfields including Immunology, Rheumatology, Clinical Biochemistry, Hematology, and Surgery.

Their recent publications cover diverse biomedical topics. Notable papers include:

  • Tubular Epithelial Cell HMGB1 Promotes AKI-CKD Transition by Sensitizing Cycling Tubular Cells to Oxidative Stress: A Rationale for Targeting HMGB1 during AKI Recovery (2023, Journal of the American Society of Nephrology)
  • Neuroinflammatory markers associate with cognitive decline after major surgery: Findings of an explorative study (2020, Annals of Neurology)
  • Sex-dependent role of microglia in disulfide high mobility group box 1 protein-mediated mechanical hypersensitivity (2020, Pain)
  • Sex- and cell-dependent contribution of peripheral high mobility group box 1 and TLR4 in arthritis-induced pain (2020, Pain)
  • Immunoprofiling of active and inactive systemic juvenile idiopathic arthritis reveals distinct biomarkers: a single-center study (2021, Pediatric Rheumatology)

The recurring themes in their research relate to immune system function and inflammatory processes, with specific attention to biomarkers, cellular stress responses, and mechanisms underlying arthritis and cognitive disorders linked to intensive care treatments.

Key topics investigated in their work include:

  • Advanced Glycation End Products research
  • Autoimmune and Inflammatory Disorders Research
  • Inflammatory mediators and NSAID effects
  • Osteoarthritis Treatment and Mechanisms
  • Intensive Care Unit Cognitive Disorders
  • S100 Proteins and Annexins
  • Rheumatoid Arthritis Research and Therapies

The scientist frequently publishes in several noted venues. These include:

  • Osteoarthritis and Cartilage
  • Pediatric Rheumatology
  • Frontiers in Immunology
  • Molecular Medicine
  • Annals of Neurology

Collaboration is prominent in Helena Erlandsson Harris's work, with consistent co-authorship alongside:

  • Cecilia Aulin
  • Erik Sundberg
  • Heshuang Qu
  • Karin Palmblad
  • Fredrik Granath

Best Publications

  • A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination.

    Lars Klareskog;Patrik Stolt;Karin Lundberg;Henrik Källberg

  • Reversing established sepsis with antagonists of endogenous high-mobility group box 1

    Huan Yang;Mahendar Ochani;Jianhua Li;Xiaoling Qiang

  • HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

    Helena Erlandsson Harris;Ulf Andersson;David S. Pisetsky

  • RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages.

    R. Kokkola;Å. Andersson;G. Mullins;T. Östberg

  • Structural basis for the proinflammatory cytokine activity of high mobility group box 1.

    Jianhua Li;Riikka Kokkola;Siamak Tabibzadeh;Runkuan Yang

  • Mini‐review: The nuclear protein HMGB1 as a proinflammatory mediator

    Helena Erlandsson Harris;Ulf Andersson

  • Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity

    R. Kokkola;J. Li;E. Sundberg;A.-C. Aveberger

  • The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation.

    Hulda Sigridur Hreggvidsdottir;Therese Östberg;Heidi Wähämaa;Hanna Schierbeck

  • High mobility group box chromosomal protein 1: A novel proinflammatory mediator in synovitis

    R. Kokkola;E. Sundberg;A.-K. Ulfgren;K. Palmblad

  • Alarmin(g) news about danger: workshop on innate danger signals and HMGB1.

    Helena Erlandsson Harris;Angela Raucci

  • MD-2 is required for disulfide HMGB1-dependent TLR4 signaling

    Huan Yang;Haichao Wang;Zhongliang Ju;Ahmed A. Ragab

  • Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity.

    Karin Lundberg;Suzanne Nijenhuis;Erik R Vossenaar;Karin Palmblad

  • High-mobility group box 1 protein (HMGB1) operates as an alarmin outside as well as inside cells

    Ulf Andersson;Huan Yang;Helena Harris

  • Extracellular HMGB1 as a therapeutic target in inflammatory diseases

    Ulf Andersson;Huan Yang;Helena Harris

  • Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus.

    Karin Popovic;Monica Ek;Alexander Espinosa;Leonid Padyukov

  • High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts.

    Heidi Wähämaa;Hanna Schierbeck;Hulda S Hreggvidsdottir;Karin Palmblad

  • Spinal HMGB1 induces TLR4-mediated long-lasting hypersensitivity and glial activation and regulates pain-like behavior in experimental arthritis

    Nilesh M. Agalave;Max Larsson;Sally Abdelmoaty;Jie Su

  • Down-regulation of the aberrant expression of the inflammation mediator high mobility group box chromosomal protein 1 in muscle tissue of patients with polymyositis and dermatomyositis treated with corticosteroids

    Ann-Kristin Ulfgren;Cecilia Grundtman;Kristian Borg;Helene Alexanderson

  • The role of HMGB1 in the pathogenesis of rheumatic disease.

    Ulf Andersson;Helena Erlandsson Harris

  • A systematic nomenclature for the redox states of high mobility group box (HMGB) proteins.

    Daniel J. Antoine;Helena Erlandsson Harris;Ulf Andersson;Kevin J. Tracey

Frequent Co-Authors

Ulf Andersson
Ulf Andersson Karolinska University Hospital
Huan Yang
Huan Yang Feinstein Institute for Medical Research
Lars Klareskog
Lars Klareskog Karolinska Institute
Lars Eriksson
Lars Eriksson Linköping University
Jianhua Li
Jianhua Li Feinstein Institute for Medical Research
Kevin J. Tracey
Kevin J. Tracey Feinstein Institute for Medical Research
Ingrid E. Lundberg
Ingrid E. Lundberg Karolinska University Hospital
Jan-Inge Henter
Jan-Inge Henter Karolinska University Hospital
Kaj Blennow
Kaj Blennow University of Gothenburg
Henrik Zetterberg
Henrik Zetterberg University of Gothenburg

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