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Molecular Biology

D-Index
52
Citations
26838
World Ranking
2405
National Ranking
188

Overview

Dónal O'Carroll is affiliated with the University of Edinburgh in the United Kingdom and conducts research primarily in the field of Biochemistry, Genetics, and Molecular Biology. Their work spans various subfields including Molecular Biology, Cancer Research, Hematology, Plant Science, and Immunology.

The scientist has contributed to the following main research topics:

  • RNA modifications and cancer
  • Chromosomal and Genetic Variations
  • CRISPR and Genetic Engineering
  • RNA Research and Splicing
  • Hematopoietic Stem Cell Transplantation
  • Epigenetics and DNA Methylation
  • Acute Myeloid Leukemia Research

O'Carroll has frequently published in several scientific venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Molecular Cell
  • Nature Communications
  • Blood

Notable recent papers authored or coauthored by O'Carroll include:

  • "SPOCD1 is an essential executor of piRNA-directed de novo DNA methylation", 2020, Nature
  • "The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function", 2020, The Journal of Experimental Medicine
  • "CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice", 2021, Circulation Research
  • "Structural and functional basis of mammalian microRNA biogenesis by Dicer", 2022, Molecular Cell
  • "TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing", 2020, Nature Communications

Frequent coauthors in their research include:

  • Kamil R. Kranc
  • Hannah Lawson
  • Ansgar Zoch
  • Yuka Kabayama
  • Joana Campos

Best Publications

  • Regulation of chromatin structure by site-specific histone H3 methyltransferases

    S Rea;F Eisenhaber;D O'Carroll;B D Strahl

  • Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.

    Monika Lachner;Dónal O'Carroll;Stephen Rea;Karl Mechtler

  • Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.

    Antoine H.F.M. Peters;Dónal O'Carroll;Harry Scherthan;Karl Mechtler

  • Blimp1 is a critical determinant of the germ cell lineage in mice

    Yasuhide Ohinata;Bernhard Payer;Dónal O'Carroll;Katia Ancelin

  • Rb targets histone H3 methylation and HP1 to promoters

    Soren J. Nielsen;Robert Schneider;Uta-Maria Bauer;Andrew J. Bannister

  • The polycomb-group gene Ezh2 is required for early mouse development.

    O'Carroll D;Erhardt S;Pagani M;Barton Sc

  • Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression

    Gerda Lagger;Dónal O'Carroll;Martina Rembold;Harald Khier

  • PIWI-interacting RNAs: small RNAs with big functions

    Deniz M. Ozata;Ildar Gainetdinov;Ansgar Zoch;Dónal O’Carroll

  • Maternal microRNAs are essential for mouse zygotic development

    Fuchou Tang;Masahiro Kaneda;Dónal O’Carroll;Petra Hajkova

  • Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs

    Rui Yi;Dónal O'Carroll;Hilda A Pasolli;Zhihong Zhang

  • Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin.

    Antoine H F M Peters;Jacqueline E Mermoud;Dónal O'Carroll;Dónal O'Carroll;Michaela Pagani

  • Cerebellar neurodegeneration in the absence of microRNAs.

    Anne Schaefer;Dónal O'Carroll;Chan Lek Tan;Dean Hillman

  • Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis

    Jr.-Shiuan Yang;Thomas Maurin;Nicolas Robine;Kasper D. Rasmussen

  • MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis.

    Katsuhiko Hayashi;Susana M. Chuva de Sousa Lopes;Masahiro Kaneda;Fuchou Tang

  • Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland

    Valerie Horsley;Dónal O'Carroll;Reuben Tooze;Yasuhide Ohinata

  • Dicer-dependent microRNA pathway safeguards regulatory T cell function.

    Adrian Liston;Li-Fan Lu;Donal O'Carroll;Alexander Tarakhovsky

  • A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway

    Dónal O’Carroll;Ingrid Mecklenbrauker;Partha Pratim Das;Angela Santana

  • Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia.

    Jasmin Paris;Jasmin Paris;Marcos Morgan;Joana Monteiro De Campos;Joana Monteiro De Campos;Gary J. Spencer

  • The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements

    Serena De Fazio;Nenad Bartonicek;Monica Di Giacomo;Cei Abreu-Goodger

  • The miR-144/451 locus is required for erythroid homeostasis

    Kasper D Rasmussen;Salvatore Simmini;Cei Abreu-Goodger;Nenad Bartonicek

Frequent Co-Authors

Anton J. Enright
Anton J. Enright University of Cambridge
Alexander Tarakhovsky
Alexander Tarakhovsky Rockefeller University
M. Azim Surani
M. Azim Surani University of Cambridge
Thomas Jenuwein
Thomas Jenuwein Max Planck Society
Juri Rappsilber
Juri Rappsilber Technical University of Berlin
Claus Nerlov
Claus Nerlov University of Oxford
Eric A. Miska
Eric A. Miska University of Cambridge
Fuchou Tang
Fuchou Tang Peking University
Robin C. Allshire
Robin C. Allshire University of Edinburgh
Sheila C. Barton
Sheila C. Barton University of Cambridge

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