World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
10828
World Ranking
17075
National Ranking
152

Overview

Alexander Schleiffer is affiliated with the Research Institute of Molecular Pathology in Austria. Their research primarily spans the field of Biochemistry, Genetics, and Molecular Biology, with a focus on Molecular Biology, Plant Science, Genetics, Cell Biology, and Oncology.

The scientist's work covers a range of main research topics including:

  • Genomics and Chromatin Dynamics
  • Ubiquitin and proteasome pathways
  • RNA Research and Splicing
  • RNA modifications and cancer
  • RNA and protein synthesis mechanisms
  • Chromosomal and Genetic Variations
  • Reproductive Biology and Fertility

Alexander Schleiffer has published extensively, with significant contributions appearing in notable venues such as bioRxiv (Cold Spring Harbor Laboratory), The EMBO Journal, eLife, Science, and Molecular Cell.

Some of Schleiffer's recent papers include:

  • Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles, 2020, Nature Methods
  • Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism, 2020, eLife
  • AKIRIN2 controls the nuclear import of proteasomes in vertebrates, 2021, Nature
  • Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins, 2022, Science
  • LSD 1 inhibition induces differentiation and cell death in Merkel cell carcinoma, 2020, EMBO Molecular Medicine

Frequent collaborators contributing to Schleiffer's work include David Haselbach, Andrea Pauli, Anton Meinhart, Tim Clausen, and Irina Grishkovskaya.

Best Publications

  • Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication.

    Attila Tóth;Rafal Ciosk;Frank Uhlmann;Marta Galova

  • Wapl Controls the Dynamic Association of Cohesin with Chromatin

    Stephanie Kueng;Björn Hegemann;Beate H. Peters;Jesse J. Lipp

  • Systematic analysis of human protein complexes identifies chromosome segregation proteins.

    James R. A. Hutchins;Yusuke Toyoda;Björn Hegemann;Ina Poser

  • Sororin Mediates Sister Chromatid Cohesion by Antagonizing Wapl

    Tomoko Nishiyama;Rene Ladurner;Julia Schmitz;Emanuel Kreidl

  • A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunction

    Pawel Pasierbek;Michael Jantsch;Martin Melcher;Alexander Schleiffer

  • Functional Genomics Identifies Monopolin: A Kinetochore Protein Required for Segregation of Homologs during Meiosis I

    Attila Tóth;Kirsten P. Rabitsch;Marta Gálová;Alexander Schleiffer

  • Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners.

    Alexander Schleiffer;Susanne Kaitna;Sebastian Maurer-Stroh;Michael Glotzer

  • Human Scc4 Is Required for Cohesin Binding to Chromatin, Sister-Chromatid Cohesion, and Mitotic Progression

    Erwan Watrin;Alexander Schleiffer;Koichi Tanaka;Frank Eisenhaber

  • A screen for genes required for meiosis and spore formation based on whole-genome expression

    Kirsten P. Rabitsch;Attila Tóth;Marta Gálová;Alexander Schleiffer

  • Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion.

    Dmitri Ivanov;Alexander Schleiffer;Frank Eisenhaber;Karl Mechtler

  • Sister chromatid separation and chromosome re‐duplication are regulated by different mechanisms in response to spindle damage

    Gabriela Alexandru;Wolfgang Zachariae;Alexander Schleiffer;Kim Nasmyth

  • Forkhead-like transcription factors recruit Ndd1 to the chromatin of G2/M-specific promoters

    Manfred Koranda;Alexander Schleiffer;Lukas Endler;Gustav Ammerer

  • HSPC117 is the essential subunit of a human tRNA splicing ligase complex.

    Johannes Popow;Markus Englert;Stefan Weitzer;Alexander Schleiffer

  • Two fission yeast homologs of Drosophila Mei-S332 are required for chromosome segregation during Meiosis I and II

    Kirsten P Rabitsch;Juraj Gregan;Alex Schleiffer;Jean-Paul Javerzat

  • Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I.

    Kirsten P Rabitsch;Mark Petronczki;Jean Paul Javerzat;Sylvie Genier

  • Switching transcription on and off during the yeast cell cycle: Cln/Cdc28 kinases activate bound transcription factor SBF (Swi4/Swi6) at start, whereas Clb/Cdc28 kinases displace it from the promoter in G2.

    C Koch;A Schleiffer;G Ammerer;K Nasmyth

  • CENP-T proteins are conserved centromere receptors of the Ndc80 complex

    Alexander Schleiffer;Michael Maier;Gabriele Litos;Fabienne Lampert

  • Mitotic Activation of the Kinase Aurora-A Requires Its Binding Partner Bora

    Andrea Hutterer;Daniela Berdnik;Daniela Berdnik;Frederik Wirtz-Peitz;Mihaela Zigman

  • Mcm1 is required to coordinate G2-specific transcription in Saccharomyces cerevisiae.

    H Althoefer;A Schleiffer;K Wassmann;A Nordheim

  • A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors

    Francesca Malvezzi;Gabriele Litos;Alexander Schleiffer;Alexander Heuck

Frequent Co-Authors

Karl Mechtler
Karl Mechtler Research Institute of Molecular Pathology
Kim Nasmyth
Kim Nasmyth University of Oxford
Tim Clausen
Tim Clausen Research Institute of Molecular Pathology
Frank Eisenhaber
Frank Eisenhaber Agency for Science, Technology and Research
Jan-Michael Peters
Jan-Michael Peters Research Institute of Molecular Pathology
Franz Herzog
Franz Herzog Ludwig-Maximilians-Universität München
Josef M. Penninger
Josef M. Penninger University of British Columbia
Dieter Schweizer
Dieter Schweizer Austrian Academy of Sciences
Martin Jinek
Martin Jinek University of Zurich
Sebastian Maurer-Stroh
Sebastian Maurer-Stroh Agency for Science, Technology and Research

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Alexander Schleiffer

Trending Scientists

Recently Published Articles